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Protein

Phosphoribosylamine--glycine ligase

Gene

purD

Organism
Methanocaldococcus fervens (strain DSM 4213 / JCM 15782 / AG86) (Methanococcus fervens)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 5-phospho-D-ribosylamine + glycine = ADP + phosphate + N1-(5-phospho-D-ribosyl)glycinamide.UniRule annotation

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Amidophosphoribosyltransferase (purF)
  2. Phosphoribosylamine--glycine ligase (purD)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate, the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationImported
Biological processPurine biosynthesisUniRule annotation
LigandATP-bindingPROSITE-ProRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciMFER573064:G1GFN-889-MONOMER.
UniPathwayiUPA00074; UER00125.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylamine--glycine ligaseUniRule annotation (EC:6.3.4.13UniRule annotation)
Alternative name(s):
GARSUniRule annotation
Glycinamide ribonucleotide synthetaseUniRule annotation
Phosphoribosylglycinamide synthetaseUniRule annotation
Gene namesi
Name:purDUniRule annotation
Ordered Locus Names:Mefer_0864Imported
OrganismiMethanocaldococcus fervens (strain DSM 4213 / JCM 15782 / AG86) (Methanococcus fervens)Imported
Taxonomic identifieri573064 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
Proteomesi
  • UP000001495 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi573064.Mefer_0864.

Structurei

3D structure databases

ProteinModelPortaliC7P800.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini109 – 324ATP-graspInterPro annotationAdd BLAST216

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili251 – 271Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the GARS family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiarCOG04415. Archaea.
COG0151. LUCA.
HOGENOMiHOG000033464.
KOiK01945.
OMAiKATVCKY.
OrthoDBiPOG093Z02WG.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.90.600.10. 1 hit.
HAMAPiMF_00138. GARS. 1 hit.
InterProiView protein in InterPro
IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR016185. PreATP-grasp_dom_sf.
IPR020561. PRibGlycinamid_synth_ATP-grasp.
IPR000115. PRibGlycinamide_synth.
IPR020560. PRibGlycinamide_synth_C-dom.
IPR037123. PRibGlycinamide_synth_C_sf.
IPR020559. PRibGlycinamide_synth_CS.
IPR020562. PRibGlycinamide_synth_N.
IPR011054. Rudment_hybrid_motif.
PfamiView protein in Pfam
PF01071. GARS_A. 1 hit.
PF02843. GARS_C. 1 hit.
PF02844. GARS_N. 1 hit.
SMARTiView protein in SMART
SM01210. GARS_C. 1 hit.
SUPFAMiSSF51246. SSF51246. 1 hit.
SSF52440. SSF52440. 1 hit.
TIGRFAMsiTIGR00877. purD. 1 hit.
PROSITEiView protein in PROSITE
PS50975. ATP_GRASP. 1 hit.
PS00184. GARS. 1 hit.

Sequencei

Sequence statusi: Complete.

C7P800-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKILLIGGGA RESAIAHALK KNEDVELYTL MKNKNPGIAR LSKEIKLAKE
60 70 80 90 100
TDLDAVKEFA EKINPDLAVI GPEAPLDVGV VDLLEDLGIP AVGPKKLAAQ
110 120 130 140 150
IETNKEFMRN LFKKYDIKGS LIYKAFEEYG EELESFIDEL TEKGIKAVVK
160 170 180 190 200
PVGLTGGKGV KVVGEQLKDN EEAKKYAKEI FETGLGGGKV LIEEKLEGVE
210 220 230 240 250
FTLHGFVDID NIKFTPFVQD HPHAFEGDEG SITGGMGSYS CPDHKLPFMT
260 270 280 290 300
EEDVEMAKEI MEETVKALKK EVGGYKGILY GQFMLTKDGP KIIEYNARFG
310 320 330 340 350
DPEAMNLLAI LKNDFLEICE AIVNKKLKDV DVEFENKATV CKYVVPKGYP
360 370 380 390 400
DNPVKGEPIS VDEEAIKKLG AILHYASVNE EDGNLYMTGS RAVAVVGVAD
410 420 430 440
TIEEAEKIAE EATKYIKGEV YHRSDIGKKE LIRKRIEKMK QLRGE
Length:445
Mass (Da):49,235
Last modified:October 13, 2009 - v1
Checksum:iCDCE89E9F4782613
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001696 Genomic DNA. Translation: ACV24682.1.
RefSeqiWP_015791419.1. NC_013156.1.

Genome annotation databases

EnsemblBacteriaiACV24682; ACV24682; Mefer_0864.
GeneIDi8365550.
KEGGimfe:Mefer_0864.

Similar proteinsi

Entry informationi

Entry nameiC7P800_METFA
AccessioniPrimary (citable) accession number: C7P800
Entry historyiIntegrated into UniProtKB/TrEMBL: October 13, 2009
Last sequence update: October 13, 2009
Last modified: February 28, 2018
This is version 58 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported