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Protein

Hypoxanthine/guanine phosphoribosyltransferase

Gene

hpt

Organism
Methanocaldococcus fervens (strain DSM 4213 / JCM 15782 / AG86) (Methanococcus fervens)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis.UniRule annotation

Catalytic activityi

IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation
GMP + diphosphate = guanine + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

Pathwayi: IMP biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes IMP from hypoxanthine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Hypoxanthine/guanine phosphoribosyltransferase (hpt)
This subpathway is part of the pathway IMP biosynthesis via salvage pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes IMP from hypoxanthine, the pathway IMP biosynthesis via salvage pathway and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processPurine salvage

Enzyme and pathway databases

BioCyciMFER573064:G1GFN-745-MONOMER
UniPathwayiUPA00591; UER00648

Names & Taxonomyi

Protein namesi
Recommended name:
Hypoxanthine/guanine phosphoribosyltransferaseUniRule annotation (EC:2.4.2.8UniRule annotation)
Short name:
HGPRTaseUniRule annotation
Gene namesi
Name:hptUniRule annotation
Ordered Locus Names:Mefer_0731
OrganismiMethanocaldococcus fervens (strain DSM 4213 / JCM 15782 / AG86) (Methanococcus fervens)
Taxonomic identifieri573064 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
Proteomesi
  • UP000001495 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004154661 – 183Hypoxanthine/guanine phosphoribosyltransferaseAdd BLAST183

Proteomic databases

PRIDEiC7P7L7

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi573064.Mefer_0731

Structurei

3D structure databases

ProteinModelPortaliC7P7L7
SMRiC7P7L7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00030 Archaea
COG0503 LUCA
HOGENOMiHOG000228520
KOiK00759
OMAiFIHPISD
OrthoDBiPOG093Z0AYC

Family and domain databases

CDDicd06223 PRTases_typeI, 1 hit
HAMAPiMF_01467 Hypx_phosphoribosyltr, 1 hit
InterProiView protein in InterPro
IPR026597 HGPRTase-like
IPR000836 PRibTrfase_dom
IPR029057 PRTase-like
PfamiView protein in Pfam
PF00156 Pribosyltran, 1 hit
SUPFAMiSSF53271 SSF53271, 1 hit
PROSITEiView protein in PROSITE
PS00103 PUR_PYR_PR_TRANSFER, 1 hit

Sequencei

Sequence statusi: Complete.

C7P7L7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLEETLKSC PIVKRGEYHY FIHPISDGVP VVDPKLLREV VTRIIKIGNF
60 70 80 90 100
EDVDKIVTAE AMGIPLVTTL SLYTDIPYVI MRKREYKLPG EIPVFQSTGY
110 120 130 140 150
SKGQLYLNGI EKGDKVVIID DVISTGGTLI AIIEALKKAG AEIKDIICVI
160 170 180
ERGEGKKIVE EKTGYKIKTL VKIDVVDGKV VIL
Length:183
Mass (Da):20,299
Last modified:October 13, 2009 - v1
Checksum:iE4C4168609D762AD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001696 Genomic DNA Translation: ACV24549.1
RefSeqiWP_015791286.1, NC_013156.1

Genome annotation databases

EnsemblBacteriaiACV24549; ACV24549; Mefer_0731
GeneIDi8365406
KEGGimfe:Mefer_0731

Similar proteinsi

Entry informationi

Entry nameiHPRT_METFA
AccessioniPrimary (citable) accession number: C7P7L7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 22, 2012
Last sequence update: October 13, 2009
Last modified: May 23, 2018
This is version 47 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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