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Protein

Proline--tRNA ligase

Gene

proS

Organism
Methanocaldococcus fervens (strain DSM 4213 / JCM 15782 / AG86) (Methanococcus fervens)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).UniRule annotation

Catalytic activityi

ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetaseUniRule annotationImported, Ligase
Biological processProtein biosynthesisUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciMFER573064:G1GFN-388-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Proline--tRNA ligaseUniRule annotation (EC:6.1.1.15UniRule annotation)
Alternative name(s):
Prolyl-tRNA synthetaseUniRule annotation
Short name:
ProRSUniRule annotation
Gene namesi
Name:proSUniRule annotation
Ordered Locus Names:Mefer_0381Imported
OrganismiMethanocaldococcus fervens (strain DSM 4213 / JCM 15782 / AG86) (Methanococcus fervens)Imported
Taxonomic identifieri573064 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
Proteomesi
  • UP000001495 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi573064.Mefer_0381.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 273AA_TRNA_LIGASE_IIInterPro annotationAdd BLAST243

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili296 – 316Sequence analysisAdd BLAST21
Coiled coili357 – 377Sequence analysisAdd BLAST21

Domaini

Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.UniRule annotation

Sequence similaritiesi

Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiarCOG00402. Archaea.
COG0442. LUCA.
HOGENOMiHOG000167538.
KOiK01881.
OMAiEVYWVTH.
OrthoDBiPOG093Z01RZ.

Family and domain databases

CDDicd00778. ProRS_core_arch_euk. 1 hit.
Gene3Di3.30.110.30. 1 hit.
3.40.50.800. 1 hit.
HAMAPiMF_01571. Pro_tRNA_synth_type3. 1 hit.
InterProiView protein in InterPro
IPR002314. aa-tRNA-synt_IIb.
IPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR036621. Anticodon-bd_dom_sf.
IPR002316. Pro-tRNA-ligase_IIa.
IPR004499. Pro-tRNA-ligase_IIa_arc-type.
IPR017449. Pro-tRNA_synth_II.
IPR015264. Pro-tRNA_synth_II_arc.
IPR033721. ProRS_core_arch_euk.
PfamiView protein in Pfam
PF03129. HGTP_anticodon. 1 hit.
PF09181. ProRS-C_2. 1 hit.
PF00587. tRNA-synt_2b. 1 hit.
PRINTSiPR01046. TRNASYNTHPRO.
SUPFAMiSSF64586. SSF64586. 1 hit.
TIGRFAMsiTIGR00408. proS_fam_I. 1 hit.
PROSITEiView protein in PROSITE
PS50862. AA_TRNA_LIGASE_II. 1 hit.

Sequencei

Sequence statusi: Complete.

C7P6N3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEFSEWYSEI LEKAEIYDVR YPIKGCGVYL PYGFKIRRYT FEIIRDLLDK
60 70 80 90 100
SGHDEALFPM LIPEDLLAKE AEHIKGFEDE VYWVTHGGKT PLDVKLALRP
110 120 130 140 150
TSETPIYYMM KLWVKVHTDL PIKIYQIVNT FRYETKHTRP LIRLREIMTF
160 170 180 190 200
KEAHTAHSTK EEAEEQVKEA ISIYKKFFDT LGIPYLISKR PEWDKFPGAE
210 220 230 240 250
YTMAFDTIFP DGRTMQIATV HNLGQNFSKT FEIIFETPTG DKDYAYQTCY
260 270 280 290 300
GISDRVIASI IAIHGDEKGL ILPPIVAPIQ IVIIPLIFKG KEDVVMEKAK
310 320 330 340 350
ELYEKLKDKY RVHIDDRDIR PGRKFNDWEI KGVPLRIEIG PKDIENGKIT
360 370 380 390 400
LFRRDTMEKF QVDESELEEV IEKTLNNIME NIKNRAHEKF ENFITILEDI
410 420 430 440 450
NPEEIKKILS EKRGVVLIPF KEEIYNEELE NKVEATILGE TEYKGKKYIA

IAKTY
Length:455
Mass (Da):53,315
Last modified:October 13, 2009 - v1
Checksum:i66F448AAFBAB712E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001696 Genomic DNA. Translation: ACV24215.1.
RefSeqiWP_015790955.1. NC_013156.1.

Genome annotation databases

EnsemblBacteriaiACV24215; ACV24215; Mefer_0381.
GeneIDi8365051.
KEGGimfe:Mefer_0381.

Similar proteinsi

Entry informationi

Entry nameiC7P6N3_METFA
AccessioniPrimary (citable) accession number: C7P6N3
Entry historyiIntegrated into UniProtKB/TrEMBL: October 13, 2009
Last sequence update: October 13, 2009
Last modified: March 28, 2018
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported