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Protein

Orotate phosphoribosyltransferase

Gene

pyrE

Organism
Methanocaldococcus fervens (strain DSM 4213 / JCM 15782 / AG86) (Methanococcus fervens)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).UniRule annotation

Catalytic activityi

Orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Pathwayi: UMP biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes UMP from orotate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Orotate phosphoribosyltransferase (pyrE)
  2. Orotidine 5'-phosphate decarboxylase (pyrF)
This subpathway is part of the pathway UMP biosynthesis via de novo pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes UMP from orotate, the pathway UMP biosynthesis via de novo pathway and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei905-phosphoribose 1-diphosphate; shared with dimeric partnerUniRule annotation1
Binding sitei915-phosphoribose 1-diphosphateUniRule annotation1
Binding sitei945-phosphoribose 1-diphosphate; shared with dimeric partnerUniRule annotation1
Binding sitei120OrotateUniRule annotation1
Binding sitei148OrotateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferaseUniRule annotationImported, Transferase
Biological processPyrimidine biosynthesisUniRule annotation
LigandMagnesiumUniRule annotation

Enzyme and pathway databases

BioCyciMFER573064:G1GFN-310-MONOMER.
UniPathwayiUPA00070; UER00119.

Names & Taxonomyi

Protein namesi
Recommended name:
Orotate phosphoribosyltransferaseUniRule annotation (EC:2.4.2.10UniRule annotation)
Short name:
OPRTUniRule annotation
Short name:
OPRTaseUniRule annotation
Gene namesi
Name:pyrEUniRule annotation
Ordered Locus Names:Mefer_0307Imported
OrganismiMethanocaldococcus fervens (strain DSM 4213 / JCM 15782 / AG86) (Methanococcus fervens)Imported
Taxonomic identifieri573064 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
Proteomesi
  • UP000001495 Componenti: Chromosome

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi573064.Mefer_0307.

Structurei

3D structure databases

ProteinModelPortaliC7P6G1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini40 – 156PribosyltranInterPro annotationAdd BLAST117

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni116 – 1245-phosphoribose 1-diphosphate bindingUniRule annotation9

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili139 – 159Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiarCOG00029. Archaea.
COG0461. LUCA.
HOGENOMiHOG000037976.
KOiK00762.
OMAiMKAYQRQ.
OrthoDBiPOG093Z0DC2.

Family and domain databases

CDDicd06223. PRTases_typeI. 1 hit.
HAMAPiMF_01208. PyrE. 1 hit.
InterProiView protein in InterPro
IPR023031. OPRT.
IPR004467. Or_phspho_trans_dom.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
PfamiView protein in Pfam
PF00156. Pribosyltran. 1 hit.
SUPFAMiSSF53271. SSF53271. 1 hit.
TIGRFAMsiTIGR00336. pyrE. 1 hit.

Sequencei

Sequence statusi: Complete.

C7P6G1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKKSKLIKL LRDIGCIKFG EFILASGKKS NYYIDIKKAT TNPEILKLVG
60 70 80 90 100
EMIAEQIRDE DVKVAGVELG SVPIATAVSI IAQKPLLIVR KKPKDYGTKN
110 120 130 140 150
KIEGELKEGD RVVIVEDVTT TGGSVLKAVN EIRENGGIVD KVFVVVDRLE
160 170
GAKENLEKEN VKLIPLVTVD ELRSA
Length:175
Mass (Da):19,215
Last modified:October 13, 2009 - v1
Checksum:iC62B44976DDD8CC6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001696 Genomic DNA. Translation: ACV24143.1.
RefSeqiWP_015790883.1. NC_013156.1.

Genome annotation databases

EnsemblBacteriaiACV24143; ACV24143; Mefer_0307.
GeneIDi8364974.
KEGGimfe:Mefer_0307.

Similar proteinsi

Entry informationi

Entry nameiC7P6G1_METFA
AccessioniPrimary (citable) accession number: C7P6G1
Entry historyiIntegrated into UniProtKB/TrEMBL: October 13, 2009
Last sequence update: October 13, 2009
Last modified: February 28, 2018
This is version 55 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Keywords - Technical termi

Complete proteomeImported