C7P5N7 (C7P5N7_METFA) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Phosphoribosylformylglycinamidine synthase 2 HAMAP MF_00420
EC=6.3.5.3 HAMAP MF_00420

Alternative name(s):
Phosphoribosylformylglycinamidine synthase II HAMAP MF_00420

Gene names

Name:	purL HAMAP MF_00420
Ordered Locus Names:	Mefer_0027

Organism

Methanocaldococcus fervens (strain DSM 4213 / JCM 157852 / AG86) (Methanococcus fervens) [Complete proteome] [HAMAP]

Taxonomic identifier

573064 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanococci › Methanococcales › Methanocaldococcaceae › Methanocaldococcus

Protein attributes

Sequence length	733 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide + L-glutamine + H2O = ADP + phosphate + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate. HAMAP MF_00420
Pathway	Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2. HAMAP MF_00420
Subunit structure	Heterodimer of two subunits, PurQ and PurL By similarity. HAMAP MF_00420
Subcellular location	Cytoplasm By similarity HAMAP MF_00420.
Sequence similarities	Belongs to the FGAMS family. HAMAP MF_00420

Ontologies

Keywords
Biological process	Purine biosynthesis HAMAP MF_00420
Cellular component	Cytoplasm HAMAP MF_00420
Ligand	ATP-binding HAMAP MF_00420 Nucleotide-binding
Molecular function	Ligase HAMAP MF_00420 EMBL ACV23869.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	'de novo' IMP biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP phosphoribosylformylglycinamidine synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	C7P5N7 [UniParc]. Last modified October 13, 2009. Version 1. Checksum: 635CB4C50FAC15F7	FASTA	733	81,015
	10 20 30 40 50 60 MDENDLRYIE KVLGRKPNHI ELAMFENLWS EHCAYRTSKK LLRMFAKTVN EKTSKHIVVG 70 80 90 100 110 120 IGDDAAVIRL KDDICLAIAM ESHNHPSYID PYNGAATGVG GIVRDVLSMG AKPIALLDPL 130 140 150 160 170 180 RFGDIFGKEG DKVRWLVEGV VKGIGDYGNR IGVPTVGGEC EFDSSFDYNN LVNVVCVGLV 190 200 210 220 230 240 RENEIITGKA KEPGLSLILV GSTGRDGIGG ASFASKDLTE ESEEERPSVQ VGDAFSEKCL 250 260 270 280 290 300 IDAVLEAIKT GKIKAMKDLG AAGLSGASSE MCYGGGVGCE LYLENVVLRE PLTPYEIMVS 310 320 330 340 350 360 ESQERMLLAV ESGSEEEVIK IFKKYELPAS VIGKTIEEKR IIAKYNGEVV VDLPLDLLCE 370 380 390 400 410 420 APLYDREAKE DLKEREDDKE KIKMPEDLNA VLLKLLESPN ICSKEWIYQQ YDHEVQIRTV 430 440 450 460 470 480 IKPGKDVAVL RIMETYPTGI ALTTDCNSRY CKLNPYVGAV NAVAEAVRNL ATVGAEPIAM 490 500 510 520 530 540 LDNLNFGNPE RSERFWQLAE CIKGLSDAAE FFEIPVVGGN VSLYNETVIE GKEFPINPTP 550 560 570 580 590 600 AIFVLGKVED VEKVPGVLDN KIREGDMLII TNETKDEMGG SEYYKVIHNT EEGRVPRVDL 610 620 630 640 650 660 DKEKKIYEEV REVIKEGLVS EAVDCSRGGL AVALAKMAIL NNIGLDVDLT TYNKNNLRDD 670 680 690 700 710 720 ILLFSETSGR IILAVREENK DKVLSKLSNA YVIGKVGGNK LKIKINGKDV IDLDVEEMKK 730 RYYEAFPKMM GEI

References

[1]

"Complete sequence of chromosome of Methanocaldococcus fervens AG86." Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D., Goodwin L., Pitluck S., Chertkov O., Detter J.C., Han C., Tapia R., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikova G., Lupa-Sieprawska M., Whitman W.B. Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 4213 / JCM 157852 / AG86.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001696 Genomic DNA. Translation: ACV23869.1.
RefSeq	YP_003127369.1. NC_013156.1.
3D structure databases
ProteinModelPortal	C7P5N7.
ModBase	Search...
Protein-protein interaction databases
STRING	C7P5N7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	8364689.
GenomeReviews	Gene locus Mefer_0027 in contig CP001696_GR.
KEGG	mfe:Mefer_0027.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	YGNSFGV.
ProtClustDB	PRK01213.
Family and domain databases
HAMAP	MF_00420. PurL_2. [Tree]
InterPro	IPR000728. AIR_synth. IPR010918. AIR_synth_C. IPR010074. PRibForGlyAmidine_synth_II. IPR016188. PurM_N-like. [Graphical view]
KO	K01952.
Pfam	PF00586. AIRS. 2 hits. PF02769. AIRS_C. 2 hits. [Graphical view]
SUPFAM	SSF56042. AIR_synth_C. 2 hits. SSF55326. PurM_N-like. 2 hits.
TIGRFAMs	TIGR01736. FGAM_synth_II. 1 hit.
ProtoNet	Search...

Entry information

Entry name

C7P5N7_METFA

Accession

Primary (citable) accession number: C7P5N7

Entry history

Integrated into UniProtKB/TrEMBL:	October 13, 2009
Last sequence update:	October 13, 2009
Last modified:	January 25, 2012
This is version 19 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)