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C7P5A4 (C7P5A4_METFA) Unreviewed, UniProtKB/TrEMBL

Last modified November 16, 2011. Version 18. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ketol-acid reductoisomerase HAMAP MF_00435
EC=1.1.1.86 HAMAP MF_00435
Alternative name(s):
Acetohydroxy-acid isomeroreductase HAMAP MF_00435
Alpha-keto-beta-hydroxylacil reductoisomerase HAMAP MF_00435
Gene names
Name:ilvC HAMAP MF_00435
Ordered Locus Names:Mefer_1479
OrganismMethanocaldococcus fervens (strain DSM 4213 / JCM 157852 / AG86) (Methanococcus fervens) [Complete proteome] [HAMAP]
Taxonomic identifier573064 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Methanococci › Methanococcales › Methanocaldococcaceae › Methanocaldococcus

Protein attributes

Sequence length330 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP+ = (S)-2-hydroxy-2-ethyl-3-oxobutanoate + NADPH. HAMAP MF_00435

(R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH. HAMAP MF_00435

Pathway

Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4. HAMAP MF_00435

Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4. HAMAP MF_00435

Sequence similarities

Belongs to the ketol-acid reductoisomerase family. HAMAP MF_00435

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site1081 By similarity HAMAP MF_00435

Sequences

Sequence LengthMass (Da)Tools
C7P5A4 [UniParc].

Last modified October 13, 2009. Version 1.
Checksum: E82FDAA2AFF4B300

FASTA33036,568
        10         20         30         40         50         60 
MVKIFYDKDV TFDAVKDKTI AVIGYGSQGR AQALNMKDSG LNVIVGLRPE GASWNKAIKD 

        70         80         90        100        110        120 
GHTVMTVEEA AEKADIIHIL IPDEVQPAVY KKQIEPHLTE GKTISFSHGY NIHYGLIKPP 

       130        140        150        160        170        180 
ENVNITMVAP KGPGAMVRKT FEEGFGVPGL VAVERDYTGD ALQIALGMAK GIGLTRAGVI 

       190        200        210        220        230        240 
ETTFREETET DLFGEQVVLC GGVTELIKAA FETLVEAGYA PEMAYFETCH ELKLIVDLIY 

       250        260        270        280        290        300 
QKGLQGMWEN VSNTAEYGGL TRRKRVINEE SRKAMKEILK EIQDGRFAKE WSLENVAGAP 

       310        320        330 
QLNALRRLEK EHLIEKVGKE LRKMCGLEKE

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References

[1]"Complete sequence of chromosome of Methanocaldococcus fervens AG86."
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D., Goodwin L., Pitluck S., Chertkov O., Detter J.C., Han C., Tapia R., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikova G., Lupa-Sieprawska M., Whitman W.B.
Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 4213 / JCM 157852 / AG86.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001696 Genomic DNA. Translation: ACV25282.1.
RefSeqYP_003128782.1. NC_013156.1.

3D structure databases

ProteinModelPortalC7P5A4.
ModBaseSearch...

Protein-protein interaction databases

STRINGC7P5A4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID8366185.
GenomeReviewsGene locus Mefer_1479 in contig CP001696_GR.
KEGGmfe:Mefer_1479.

Organism-specific databases

CMRSearch...

Phylogenomic databases

OMAMAYAKGI.
ProtClustDBPRK05479.

Family and domain databases

HAMAPMF_00435. IlvC.
[Tree]
InterProIPR008927. 6-PGluconate_DH_C-like.
IPR013023. AcH_isomrdctse.
IPR000506. AcH_isomrdctse_C.
IPR013328. DH_multihelical.
IPR013116. IlvN.
[Graphical view]
Gene3DG3DSA:1.10.1040.10. Opine_DH. 1 hit.
KOK00053.
PANTHERPTHR21371. AcH_isomrdctse. 1 hit.
PfamPF01450. IlvC. 1 hit.
PF07991. IlvN. 1 hit.
[Graphical view]
SUPFAMSSF48179. 6DGDH_C_like. 1 hit.
TIGRFAMsTIGR00465. IlvC. 1 hit.
ProtoNetSearch...

Entry information

Entry nameC7P5A4_METFA
AccessionPrimary (citable) accession number: C7P5A4
Entry history
Integrated into UniProtKB/TrEMBL: October 13, 2009
Last sequence update: October 13, 2009
Last modified: November 16, 2011
This is version 18 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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