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C7P4Q7 (C7P4Q7_HALMD) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 18. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phosphoribosylformylglycinamidine synthase 2 HAMAP MF_00420
EC=6.3.5.3 HAMAP MF_00420
Alternative name(s):
Phosphoribosylformylglycinamidine synthase II HAMAP MF_00420
Gene names
Name:purL HAMAP MF_00420
Ordered Locus Names:Hmuk_1966
OrganismHalomicrobium mukohataei (strain ATCC 700874 / DSM 12286 / JCM 9738 / NCIMB 13541) (Haloarcula mukohataei) [Complete proteome] [HAMAP]
Taxonomic identifier485914 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Halobacteria › Halobacteriales › Halobacteriaceae › Halomicrobium

Protein attributes

Sequence length731 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide + L-glutamine + H2O = ADP + phosphate + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate. HAMAP MF_00420

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2. HAMAP MF_00420

Subunit structure

Heterodimer of two subunits, PurQ and PurL By similarity. HAMAP MF_00420

Subcellular location

Cytoplasm By similarity HAMAP MF_00420.

Sequence similarities

Belongs to the FGAMS family. HAMAP MF_00420

Ontologies

Keywords
   Biological processPurine biosynthesis HAMAP MF_00420
   Cellular componentCytoplasm HAMAP MF_00420
   LigandATP-binding HAMAP MF_00420
Nucleotide-binding
   Molecular functionLigase HAMAP MF_00420 EMBL ACV48079.1
   Technical termComplete proteome
Gene Ontology (GO)
   Biological process'de novo' IMP biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionATP binding

Inferred from electronic annotation. Source: HAMAP

phosphoribosylformylglycinamidine synthase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
C7P4Q7 [UniParc].

Last modified October 13, 2009. Version 1.
Checksum: EA363C9A9952C735

FASTA73176,460
        10         20         30         40         50         60 
MSLSDADHDL VVEELGREPT QAEAALFENL WSEHCAYRSS RPLLGAFDSE GDQVVVGPGD 

        70         80         90        100        110        120 
DAAVVELPDS DGTYITMGIE SHNHPSYVDP FDGAATGVGG IVRDTLSMGA YPIALADSLY 

       130        140        150        160        170        180 
FGDFDREHSR YLLEGVVEGI SHYGNCIGVP TVTGSAAFHE DYEGNPLVNV SCIGLVDEER 

       190        200        210        220        230        240 
MITAVAQQPG NKLVLVGNST GRDGLGGASF ASEDLAEDAE TEDRPAVQVG DPYTEKLLIE 

       250        260        270        280        290        300 
ANEQLIDEGL IESARDLGAA GLGGASSELV AKGGLGAEIE LTEVHEREPN MNAMEYLLAE 

       310        320        330        340        350        360 
SQERMCYEVA PENVDRVREI ADRFDLGASV IGEVTDTGDY VCTFEGETVV DCDAEFLGEG 

       370        380        390        400        410        420 
APFNDLPFEE PTQPERDLPD GVALDDAFES VVASPNTASK RWVYRQYDHE VQVRTATPPG 

       430        440        450        460        470        480 
DDAAVLAVRE AGAAAGQAGD DGETGVGLAY TAGADPNWTD TAPYEGARAV ALENATNLAA 

       490        500        510        520        530        540 
KGTTPLAAVD CLNGGNPEKP DVYGAFKGIV DGLADMCSTL DIPVVGGNVS LYNDSVAGPI 

       550        560        570        580        590        600 
PPTPTLAAVG TKDGYEAPPM SLSGEGELLL VGARALEGDA EPRLGGSEYL TQFGGTDRFP 

       610        620        630        640        650        660 
TLLDTPDAFI ETLADVANED ATLATHDLCH GGLAVGLAEM VHEDGGASVE IDAPNKGSVA 

       670        680        690        700        710        720 
ELLFGEQPGR VVIETADARA VREAFDGVAP VYDLGSADES GALDLTVNGQ SLAYNADEIA 

       730 
GLRSTITNEL E

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001688 Genomic DNA. Translation: ACV48079.1.
RefSeqYP_003177786.1. NC_013202.1.

3D structure databases

ProteinModelPortalC7P4Q7.
ModBaseSearch...

Protein-protein interaction databases

STRINGC7P4Q7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID8411495.
GenomeReviewsGene locus Hmuk_1966 in contig CP001688_GR.
KEGGhmu:Hmuk_1966.

Organism-specific databases

CMRSearch...

Phylogenomic databases

OMAYGNSFGV.
ProtClustDBPRK01213.

Family and domain databases

HAMAPMF_00420. PurL_2.
[Tree]
InterProIPR000728. AIR_synth.
IPR010918. AIR_synth_C.
IPR010074. PRibForGlyAmidine_synth_II.
IPR016188. PurM_N-like.
[Graphical view]
KOK01952.
PfamPF00586. AIRS. 2 hits.
PF02769. AIRS_C. 2 hits.
[Graphical view]
SUPFAMSSF56042. AIR_synth_C. 2 hits.
SSF55326. PurM_N-like. 2 hits.
TIGRFAMsTIGR01736. FGAM_synth_II. 1 hit.
ProtoNetSearch...

Entry information

Entry nameC7P4Q7_HALMD
AccessionPrimary (citable) accession number: C7P4Q7
Entry history
Integrated into UniProtKB/TrEMBL: October 13, 2009
Last sequence update: October 13, 2009
Last modified: January 25, 2012
This is version 18 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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