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C7P079

- C7P079_HALMD

UniProt

C7P079 - C7P079_HALMD

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Protein

Ribulose bisphosphate carboxylase

Gene

rbcL

Organism
Halomicrobium mukohataei (strain ATCC 700874 / DSM 12286 / JCM 9738 / NCIMB 13541) (Haloarcula mukohataei)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the addition of molecular CO2 and H2O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3-phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase.UniRule annotation

Catalytic activityi

2 3-phospho-D-glycerate + 2 H+ = D-ribulose 1,5-bisphosphate + CO2 + H2O.UniRule annotation
3-phospho-D-glycerate + 2-phosphoglycolate = D-ribulose 1,5-bisphosphate + O2.UniRule annotation

Cofactori

Binds 1 magnesium ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei159 – 1591Proton acceptorUniRule annotation
Binding sitei161 – 1611SubstrateUniRule annotation
Metal bindingi185 – 1851Magnesium; via carbamate groupUniRule annotation
Metal bindingi187 – 1871MagnesiumUniRule annotation
Metal bindingi188 – 1881MagnesiumUniRule annotation
Active sitei277 – 2771Proton acceptorUniRule annotation
Binding sitei278 – 2781SubstrateUniRule annotation
Binding sitei310 – 3101SubstrateUniRule annotation
Sitei318 – 3181Transition state stabilizerUniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. oxidoreductase activity Source: UniProtKB-KW
  3. ribulose-bisphosphate carboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. AMP catabolic process Source: UniProtKB-HAMAP
  2. carbon fixation Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationImported, OxidoreductaseUniRule annotation

Keywords - Biological processi

Carbon dioxide fixationUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciHMUK485914:GCKD-2821-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribulose bisphosphate carboxylaseUniRule annotation (EC:4.1.1.39UniRule annotation)
Short name:
RuBisCOUniRule annotation
Gene namesi
Name:rbcLUniRule annotation
Ordered Locus Names:Hmuk_2766Imported
OrganismiHalomicrobium mukohataei (strain ATCC 700874 / DSM 12286 / JCM 9738 / NCIMB 13541) (Haloarcula mukohataei)Imported
Taxonomic identifieri485914 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalomicrobium
ProteomesiUP000001746: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei185 – 1851N6-carboxylysineUniRule annotation

Interactioni

Subunit structurei

Homodimer or homodecamer. In contrast to form I RuBisCO, the form III RuBisCO is composed solely of large subunits.UniRule annotation

Protein-protein interaction databases

STRINGi485914.Hmuk_2766.

Structurei

3D structure databases

ProteinModelPortaliC7P079.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni346 – 3483Substrate bindingUniRule annotation
Regioni368 – 3714Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the RuBisCO large chain family.UniRule annotation
Belongs to the RuBisCO large chain family. Type III subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG1850.
HOGENOMiHOG000230831.
KOiK01601.
OMAiFTQDWAS.

Family and domain databases

Gene3Di3.20.20.110. 1 hit.
3.30.70.150. 1 hit.
InterProiIPR017712. RuBisCO_III.
IPR000685. RuBisCO_lsu_C.
IPR017443. RuBisCO_lsu_fd_N.
IPR017444. RuBisCO_lsu_N.
[Graphical view]
PfamiPF00016. RuBisCO_large. 1 hit.
PF02788. RuBisCO_large_N. 1 hit.
[Graphical view]
SUPFAMiSSF51649. SSF51649. 1 hit.
SSF54966. SSF54966. 1 hit.
TIGRFAMsiTIGR03326. rubisco_III. 1 hit.

Sequencei

Sequence statusi: Complete.

C7P079-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVGITYEDFL DLSYDPADSD LVCEFYVEPA ADQDAESAAS RVASESSNGT
60 70 80 90 100
WAELQVDGGV TDLSATACGI EAATAGDREG YRVTVAYPDA LFEGGNMPQI
110 120 130 140 150
LSCIAGNILG MKAVDRIRLL DCTWPEPLAT SFAGPQFGTS VRSEIFDADD
160 170 180 190 200
RPITATVPKP KVGLSTDQHA QIGYEAWTGG LDLLKDDENL TDQAFNPFED
210 220 230 240 250
RLTESLAQRD RAVEETGEPK SYLLNVTAGG TEMLERVDMA AEHGCEYVMV
260 270 280 290 300
DVVTCGWAAV QQVRERCERH GLAIHAHRAM HAAFDRLPSH GVSMRVIAQI
310 320 330 340 350
ARLCGVDQIH TGTADLGKLA NEDTVGINEW LTSDLYGLDD VLPMASGGLH
360 370 380 390 400
PGLVPELVDR CGTNIGIQAG GGVHGHPDGT HEGAKALRAA VEAAAEGRSI
410 420
EAAADDEPAL ATALDKWGTE TPR
Length:423
Mass (Da):45,051
Last modified:October 13, 2009 - v1
Checksum:iA20101D19FB685BA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001688 Genomic DNA. Translation: ACV48871.1.
RefSeqiYP_003178578.1. NC_013202.1.

Genome annotation databases

EnsemblBacteriaiACV48871; ACV48871; Hmuk_2766.
GeneIDi8412317.
KEGGihmu:Hmuk_2766.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001688 Genomic DNA. Translation: ACV48871.1 .
RefSeqi YP_003178578.1. NC_013202.1.

3D structure databases

ProteinModelPortali C7P079.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 485914.Hmuk_2766.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACV48871 ; ACV48871 ; Hmuk_2766 .
GeneIDi 8412317.
KEGGi hmu:Hmuk_2766.

Phylogenomic databases

eggNOGi COG1850.
HOGENOMi HOG000230831.
KOi K01601.
OMAi FTQDWAS.

Enzyme and pathway databases

BioCyci HMUK485914:GCKD-2821-MONOMER.

Family and domain databases

Gene3Di 3.20.20.110. 1 hit.
3.30.70.150. 1 hit.
InterProi IPR017712. RuBisCO_III.
IPR000685. RuBisCO_lsu_C.
IPR017443. RuBisCO_lsu_fd_N.
IPR017444. RuBisCO_lsu_N.
[Graphical view ]
Pfami PF00016. RuBisCO_large. 1 hit.
PF02788. RuBisCO_large_N. 1 hit.
[Graphical view ]
SUPFAMi SSF51649. SSF51649. 1 hit.
SSF54966. SSF54966. 1 hit.
TIGRFAMsi TIGR03326. rubisco_III. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700874 / DSM 12286 / JCM 9738 / NCIMB 13541Imported.

Entry informationi

Entry nameiC7P079_HALMD
AccessioniPrimary (citable) accession number: C7P079
Entry historyi
Integrated into UniProtKB/TrEMBL: October 13, 2009
Last sequence update: October 13, 2009
Last modified: October 29, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Miscellaneous

Because the Archaea possessing a type III RuBisCO are all anaerobic, it is most likely that only the carboxylase activity of RuBisCO, and not the competitive oxygenase activity (by which RuBP reacts with O2 to form one molecule of 3-phosphoglycerate and one molecule of 2-phosphoglycolate), is biologically relevant in these strains.UniRule annotation

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3