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C7P079

- C7P079_HALMD

UniProt

C7P079 - C7P079_HALMD

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Protein

Ribulose bisphosphate carboxylase

Gene
rbcL, Hmuk_2766
Organism
Halomicrobium mukohataei (strain ATCC 700874 / DSM 12286 / JCM 9738 / NCIMB 13541) (Haloarcula mukohataei)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the addition of molecular CO2 and H2O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3-phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase By similarity.UniRule annotation

Catalytic activityi

2 3-phospho-D-glycerate + 2 H+ = D-ribulose 1,5-bisphosphate + CO2 + H2O.UniRule annotation
3-phospho-D-glycerate + 2-phosphoglycolate = D-ribulose 1,5-bisphosphate + O2.UniRule annotation

Cofactori

Binds 1 magnesium ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei159 – 1591Proton acceptor By similarityUniRule annotation
Binding sitei161 – 1611Substrate By similarityUniRule annotation
Metal bindingi185 – 1851Magnesium; via carbamate group By similarityUniRule annotation
Metal bindingi187 – 1871Magnesium By similarityUniRule annotation
Metal bindingi188 – 1881Magnesium By similarityUniRule annotation
Active sitei277 – 2771Proton acceptor By similarityUniRule annotation
Binding sitei278 – 2781Substrate By similarityUniRule annotation
Binding sitei310 – 3101Substrate By similarityUniRule annotation
Sitei318 – 3181Transition state stabilizer By similarityUniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: InterPro
  2. ribulose-bisphosphate carboxylase activity Source: UniProtKB-EC

GO - Biological processi

  1. carbon fixation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationImported, OxidoreductaseUniRule annotation

Keywords - Biological processi

Carbon dioxide fixationUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciHMUK485914:GCKD-2821-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribulose bisphosphate carboxylaseUniRule annotation (EC:4.1.1.39UniRule annotation)
Short name:
RuBisCOUniRule annotation
Gene namesi
Name:rbcLUniRule annotation
Ordered Locus Names:Hmuk_2766Imported
OrganismiHalomicrobium mukohataei (strain ATCC 700874 / DSM 12286 / JCM 9738 / NCIMB 13541) (Haloarcula mukohataei)Imported
Taxonomic identifieri485914 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalomicrobium
ProteomesiUP000001746: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei185 – 1851N6-carboxylysine By similarityUniRule annotation

Interactioni

Subunit structurei

Homodimer or homodecamer. In contrast to form I RuBisCO, the form III RuBisCO is composed solely of large subunits By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi485914.Hmuk_2766.

Structurei

3D structure databases

ProteinModelPortaliC7P079.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni346 – 3483Substrate binding By similarityUniRule annotation
Regioni368 – 3714Substrate binding By similarityUniRule annotation

Sequence similaritiesi

Belongs to the RuBisCO large chain family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1850.
HOGENOMiHOG000230831.
KOiK01601.
OMAiFTQDWAS.

Family and domain databases

Gene3Di3.20.20.110. 1 hit.
3.30.70.150. 1 hit.
InterProiIPR017712. RuBisCO_III.
IPR000685. RuBisCO_lsu_C.
IPR017443. RuBisCO_lsu_fd_N.
IPR017444. RuBisCO_lsu_N.
[Graphical view]
PfamiPF00016. RuBisCO_large. 1 hit.
PF02788. RuBisCO_large_N. 1 hit.
[Graphical view]
SUPFAMiSSF51649. SSF51649. 1 hit.
SSF54966. SSF54966. 1 hit.
TIGRFAMsiTIGR03326. rubisco_III. 1 hit.

Sequencei

Sequence statusi: Complete.

C7P079-1 [UniParc]FASTAAdd to Basket

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MVGITYEDFL DLSYDPADSD LVCEFYVEPA ADQDAESAAS RVASESSNGT    50
WAELQVDGGV TDLSATACGI EAATAGDREG YRVTVAYPDA LFEGGNMPQI 100
LSCIAGNILG MKAVDRIRLL DCTWPEPLAT SFAGPQFGTS VRSEIFDADD 150
RPITATVPKP KVGLSTDQHA QIGYEAWTGG LDLLKDDENL TDQAFNPFED 200
RLTESLAQRD RAVEETGEPK SYLLNVTAGG TEMLERVDMA AEHGCEYVMV 250
DVVTCGWAAV QQVRERCERH GLAIHAHRAM HAAFDRLPSH GVSMRVIAQI 300
ARLCGVDQIH TGTADLGKLA NEDTVGINEW LTSDLYGLDD VLPMASGGLH 350
PGLVPELVDR CGTNIGIQAG GGVHGHPDGT HEGAKALRAA VEAAAEGRSI 400
EAAADDEPAL ATALDKWGTE TPR 423
Length:423
Mass (Da):45,051
Last modified:October 13, 2009 - v1
Checksum:iA20101D19FB685BA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001688 Genomic DNA. Translation: ACV48871.1.
RefSeqiYP_003178578.1. NC_013202.1.

Genome annotation databases

EnsemblBacteriaiACV48871; ACV48871; Hmuk_2766.
GeneIDi8412317.
KEGGihmu:Hmuk_2766.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001688 Genomic DNA. Translation: ACV48871.1 .
RefSeqi YP_003178578.1. NC_013202.1.

3D structure databases

ProteinModelPortali C7P079.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 485914.Hmuk_2766.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACV48871 ; ACV48871 ; Hmuk_2766 .
GeneIDi 8412317.
KEGGi hmu:Hmuk_2766.

Phylogenomic databases

eggNOGi COG1850.
HOGENOMi HOG000230831.
KOi K01601.
OMAi FTQDWAS.

Enzyme and pathway databases

BioCyci HMUK485914:GCKD-2821-MONOMER.

Family and domain databases

Gene3Di 3.20.20.110. 1 hit.
3.30.70.150. 1 hit.
InterProi IPR017712. RuBisCO_III.
IPR000685. RuBisCO_lsu_C.
IPR017443. RuBisCO_lsu_fd_N.
IPR017444. RuBisCO_lsu_N.
[Graphical view ]
Pfami PF00016. RuBisCO_large. 1 hit.
PF02788. RuBisCO_large_N. 1 hit.
[Graphical view ]
SUPFAMi SSF51649. SSF51649. 1 hit.
SSF54966. SSF54966. 1 hit.
TIGRFAMsi TIGR03326. rubisco_III. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700874 / DSM 12286 / JCM 9738 / NCIMB 13541.

Entry informationi

Entry nameiC7P079_HALMD
AccessioniPrimary (citable) accession number: C7P079
Entry historyi
Integrated into UniProtKB/TrEMBL: October 13, 2009
Last sequence update: October 13, 2009
Last modified: September 3, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Miscellaneous

Because the Archaea possessing a type III RuBisCO are all anaerobic, it is most likely that only the carboxylase activity of RuBisCO, and not the competitive oxygenase activity (by which RuBP reacts with O2 to form one molecule of 3-phosphoglycerate and one molecule of 2-phosphoglycolate), is biologically relevant in these strains By similarity.UniRule annotation

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

Similar proteinsi