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C7P079

- C7P079_HALMD

UniProt

C7P079 - C7P079_HALMD

Protein

Ribulose bisphosphate carboxylase

Gene

rbcL

Organism
Halomicrobium mukohataei (strain ATCC 700874 / DSM 12286 / JCM 9738 / NCIMB 13541) (Haloarcula mukohataei)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 37 (01 Oct 2014)
      Sequence version 1 (13 Oct 2009)
      Previous versions | rss
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    Functioni

    Catalyzes the addition of molecular CO2 and H2O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3-phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase.UniRule annotation

    Catalytic activityi

    2 3-phospho-D-glycerate + 2 H+ = D-ribulose 1,5-bisphosphate + CO2 + H2O.UniRule annotation
    3-phospho-D-glycerate + 2-phosphoglycolate = D-ribulose 1,5-bisphosphate + O2.UniRule annotation

    Cofactori

    Binds 1 magnesium ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei159 – 1591Proton acceptorUniRule annotation
    Binding sitei161 – 1611SubstrateUniRule annotation
    Metal bindingi185 – 1851Magnesium; via carbamate groupUniRule annotation
    Metal bindingi187 – 1871MagnesiumUniRule annotation
    Metal bindingi188 – 1881MagnesiumUniRule annotation
    Active sitei277 – 2771Proton acceptorUniRule annotation
    Binding sitei278 – 2781SubstrateUniRule annotation
    Binding sitei310 – 3101SubstrateUniRule annotation
    Sitei318 – 3181Transition state stabilizerUniRule annotation

    GO - Molecular functioni

    1. magnesium ion binding Source: UniProtKB-HAMAP
    2. ribulose-bisphosphate carboxylase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. AMP catabolic process Source: UniProtKB-HAMAP
    2. carbon fixation Source: InterPro

    Keywords - Molecular functioni

    LyaseUniRule annotationImported, OxidoreductaseUniRule annotation

    Keywords - Biological processi

    Carbon dioxide fixationUniRule annotation

    Keywords - Ligandi

    MagnesiumUniRule annotation, Metal-bindingUniRule annotation

    Enzyme and pathway databases

    BioCyciHMUK485914:GCKD-2821-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribulose bisphosphate carboxylaseUniRule annotation (EC:4.1.1.39UniRule annotation)
    Short name:
    RuBisCOUniRule annotation
    Gene namesi
    Name:rbcLUniRule annotation
    Ordered Locus Names:Hmuk_2766Imported
    OrganismiHalomicrobium mukohataei (strain ATCC 700874 / DSM 12286 / JCM 9738 / NCIMB 13541) (Haloarcula mukohataei)Imported
    Taxonomic identifieri485914 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalomicrobium
    ProteomesiUP000001746: Chromosome

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei185 – 1851N6-carboxylysineUniRule annotation

    Interactioni

    Subunit structurei

    Homodimer or homodecamer. In contrast to form I RuBisCO, the form III RuBisCO is composed solely of large subunits.UniRule annotation

    Protein-protein interaction databases

    STRINGi485914.Hmuk_2766.

    Structurei

    3D structure databases

    ProteinModelPortaliC7P079.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni346 – 3483Substrate bindingUniRule annotation
    Regioni368 – 3714Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the RuBisCO large chain family.UniRule annotation
    Belongs to the RuBisCO large chain family. Type III subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1850.
    HOGENOMiHOG000230831.
    KOiK01601.
    OMAiFTQDWAS.

    Family and domain databases

    Gene3Di3.20.20.110. 1 hit.
    3.30.70.150. 1 hit.
    InterProiIPR017712. RuBisCO_III.
    IPR000685. RuBisCO_lsu_C.
    IPR017443. RuBisCO_lsu_fd_N.
    IPR017444. RuBisCO_lsu_N.
    [Graphical view]
    PfamiPF00016. RuBisCO_large. 1 hit.
    PF02788. RuBisCO_large_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF51649. SSF51649. 1 hit.
    SSF54966. SSF54966. 1 hit.
    TIGRFAMsiTIGR03326. rubisco_III. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    C7P079-1 [UniParc]FASTAAdd to Basket

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    MVGITYEDFL DLSYDPADSD LVCEFYVEPA ADQDAESAAS RVASESSNGT    50
    WAELQVDGGV TDLSATACGI EAATAGDREG YRVTVAYPDA LFEGGNMPQI 100
    LSCIAGNILG MKAVDRIRLL DCTWPEPLAT SFAGPQFGTS VRSEIFDADD 150
    RPITATVPKP KVGLSTDQHA QIGYEAWTGG LDLLKDDENL TDQAFNPFED 200
    RLTESLAQRD RAVEETGEPK SYLLNVTAGG TEMLERVDMA AEHGCEYVMV 250
    DVVTCGWAAV QQVRERCERH GLAIHAHRAM HAAFDRLPSH GVSMRVIAQI 300
    ARLCGVDQIH TGTADLGKLA NEDTVGINEW LTSDLYGLDD VLPMASGGLH 350
    PGLVPELVDR CGTNIGIQAG GGVHGHPDGT HEGAKALRAA VEAAAEGRSI 400
    EAAADDEPAL ATALDKWGTE TPR 423
    Length:423
    Mass (Da):45,051
    Last modified:October 13, 2009 - v1
    Checksum:iA20101D19FB685BA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001688 Genomic DNA. Translation: ACV48871.1.
    RefSeqiYP_003178578.1. NC_013202.1.

    Genome annotation databases

    EnsemblBacteriaiACV48871; ACV48871; Hmuk_2766.
    GeneIDi8412317.
    KEGGihmu:Hmuk_2766.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001688 Genomic DNA. Translation: ACV48871.1 .
    RefSeqi YP_003178578.1. NC_013202.1.

    3D structure databases

    ProteinModelPortali C7P079.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 485914.Hmuk_2766.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACV48871 ; ACV48871 ; Hmuk_2766 .
    GeneIDi 8412317.
    KEGGi hmu:Hmuk_2766.

    Phylogenomic databases

    eggNOGi COG1850.
    HOGENOMi HOG000230831.
    KOi K01601.
    OMAi FTQDWAS.

    Enzyme and pathway databases

    BioCyci HMUK485914:GCKD-2821-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.110. 1 hit.
    3.30.70.150. 1 hit.
    InterProi IPR017712. RuBisCO_III.
    IPR000685. RuBisCO_lsu_C.
    IPR017443. RuBisCO_lsu_fd_N.
    IPR017444. RuBisCO_lsu_N.
    [Graphical view ]
    Pfami PF00016. RuBisCO_large. 1 hit.
    PF02788. RuBisCO_large_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51649. SSF51649. 1 hit.
    SSF54966. SSF54966. 1 hit.
    TIGRFAMsi TIGR03326. rubisco_III. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700874 / DSM 12286 / JCM 9738 / NCIMB 13541Imported.

    Entry informationi

    Entry nameiC7P079_HALMD
    AccessioniPrimary (citable) accession number: C7P079
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 13, 2009
    Last sequence update: October 13, 2009
    Last modified: October 1, 2014
    This is version 37 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Miscellaneous

    Because the Archaea possessing a type III RuBisCO are all anaerobic, it is most likely that only the carboxylase activity of RuBisCO, and not the competitive oxygenase activity (by which RuBP reacts with O2 to form one molecule of 3-phosphoglycerate and one molecule of 2-phosphoglycolate), is biologically relevant in these strains.UniRule annotation

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3