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C7NZR5 (C7NZR5_HALMD) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 33. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Type 2 DNA topoisomerase 6 subunit A HAMAP-Rule MF_00132

EC=5.99.1.3 HAMAP-Rule MF_00132
Alternative name(s):
Type II DNA topoisomerase VI subunit A HAMAP-Rule MF_00132
Gene names
Name:top6A HAMAP-Rule MF_00132
Ordered Locus Names:Hmuk_2727 EMBL ACV48833.1
OrganismHalomicrobium mukohataei (strain ATCC 700874 / DSM 12286 / JCM 9738 / NCIMB 13541) (Haloarcula mukohataei) [Complete proteome] [HAMAP] EMBL ACV48833.1
Taxonomic identifier485914 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalomicrobium

Protein attributes

Sequence length366 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Relaxes both positive and negative superturns and exhibits a strong decatenase activity By similarity. HAMAP-Rule MF_00132

Catalytic activity

ATP-dependent breakage, passage and rejoining of double-stranded DNA. HAMAP-Rule MF_00132

Cofactor

Magnesium By similarity. HAMAP-Rule MF_00132

Subunit structure

Homodimer. Heterotetramer of two Top6A and two Top6B chains By similarity. HAMAP-Rule MF_00132

Sequence similarities

Belongs to the TOP6A family. HAMAP-Rule MF_00132

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site1011Nucleophile By similarity HAMAP-Rule MF_00132
Metal binding1991Magnesium By similarity HAMAP-Rule MF_00132
Metal binding2511Magnesium By similarity HAMAP-Rule MF_00132

Sequences

Sequence LengthMass (Da)Tools
C7NZR5 [UniParc].

Last modified October 13, 2009. Version 1.
Checksum: 7CB5261BC4E2B5E1

FASTA36641,726
        10         20         30         40         50         60 
MSTDSNLNEA EAREQLLDLA ADFYDQFAEG DVPTMQIPTR TKSNIEYDED KDVWVYGDRS 

        70         80         90        100        110        120 
STRSAKTVSG AQKLLKATYT IDFLAQQLEE DRSSTLRELY YLSESWDLDE AQFNTQDESN 

       130        140        150        160        170        180 
NLIEDLEIVS EVKREDFHMR PEESGAKVMG PLLLREQTRR GDREIHCQDD VGQGGYQIPN 

       190        200        210        220        230        240 
NPDTIEFLDN DADFVLCVET GGMRDRLVEN GFDDEYDSIV VHLGGQPARA TRRLTKRLHD 

       250        260        270        280        290        300 
ELDLPVVVFT DGDPWSYRIY GSVAYGSIKS AHLSEYLATP EAQFIGIRPE DIVEYDLPTD 

       310        320        330        340        350        360 
PLSDSDINAL ESELEDPRFQ TEFWEEQIEL QLDIGKKSEQ QALASRGLDF VTDTYLPERL 


TEMGVL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001688 Genomic DNA. Translation: ACV48833.1.
RefSeqYP_003178540.1. NC_013202.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING485914.Hmuk_2727.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACV48833; ACV48833; Hmuk_2727.
GeneID8412278.
KEGGhmu:Hmuk_2727.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1697.
HOGENOMHOG000225930.
KOK03166.
OMAENTFEDQ.
ProtClustDBPRK04342.

Enzyme and pathway databases

BioCycHMUK485914:GCKD-2782-MONOMER.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
HAMAPMF_00132. Top6A.
InterProIPR002815. Spo11/TopoVI_A.
IPR013049. Spo11/TopoVI_A_N.
IPR004085. TopoVI_A.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERPTHR10848. PTHR10848. 1 hit.
PfamPF04406. TP6A_N. 1 hit.
[Graphical view]
PRINTSPR01550. TOP6AFAMILY.
PR01552. TPISMRASE6A.
SUPFAMSSF56726. SSF56726. 1 hit.
ProtoNetSearch...

Entry information

Entry nameC7NZR5_HALMD
AccessionPrimary (citable) accession number: C7NZR5
Entry history
Integrated into UniProtKB/TrEMBL: October 13, 2009
Last sequence update: October 13, 2009
Last modified: February 19, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)