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C7NZR5

- C7NZR5_HALMD

UniProt

C7NZR5 - C7NZR5_HALMD

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Protein

Type 2 DNA topoisomerase 6 subunit A

Gene
top6A, Hmuk_2727
Organism
Halomicrobium mukohataei (strain ATCC 700874 / DSM 12286 / JCM 9738 / NCIMB 13541) (Haloarcula mukohataei)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Relaxes both positive and negative superturns and exhibits a strong decatenase activity By similarity.UniRule annotation

Catalytic activityi

ATP-dependent breakage, passage and rejoining of double-stranded DNA.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei101 – 1011Nucleophile By similarityUniRule annotation
Metal bindingi199 – 1991Magnesium By similarityUniRule annotation
Metal bindingi251 – 2511Magnesium By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA binding Source: UniProtKB-HAMAP
  3. DNA topoisomerase type II (ATP-hydrolyzing) activity Source: UniProtKB-HAMAP
  4. magnesium ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA topological change Source: UniProtKB-HAMAP
  2. DNA unwinding involved in DNA replication Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase, TopoisomeraseUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, DNA-bindingUniRule annotation, MagnesiumUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciHMUK485914:GCKD-2782-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Type 2 DNA topoisomerase 6 subunit AUniRule annotation (EC:5.99.1.3UniRule annotation)
Alternative name(s):
Type II DNA topoisomerase VI subunit A
Gene namesi
Name:top6AUniRule annotation
Ordered Locus Names:Hmuk_2727Imported
OrganismiHalomicrobium mukohataei (strain ATCC 700874 / DSM 12286 / JCM 9738 / NCIMB 13541) (Haloarcula mukohataei)Imported
Taxonomic identifieri485914 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalomicrobium
ProteomesiUP000001746: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. chromosome Source: InterPro
Complete GO annotation...

Interactioni

Subunit structurei

Homodimer. Heterotetramer of two Top6A and two Top6B chains By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi485914.Hmuk_2727.

Family & Domainsi

Sequence similaritiesi

Belongs to the TOP6A family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1697.
HOGENOMiHOG000225930.
KOiK03166.
OMAiENTFEDQ.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
HAMAPiMF_00132. Top6A.
InterProiIPR002815. Spo11/TopoVI_A.
IPR013049. Spo11/TopoVI_A_N.
IPR004085. TopoVI_A.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR10848. PTHR10848. 1 hit.
PfamiPF04406. TP6A_N. 1 hit.
[Graphical view]
PRINTSiPR01550. TOP6AFAMILY.
PR01552. TPISMRASE6A.
SUPFAMiSSF56726. SSF56726. 1 hit.

Sequencei

Sequence statusi: Complete.

C7NZR5-1 [UniParc]FASTAAdd to Basket

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MSTDSNLNEA EAREQLLDLA ADFYDQFAEG DVPTMQIPTR TKSNIEYDED    50
KDVWVYGDRS STRSAKTVSG AQKLLKATYT IDFLAQQLEE DRSSTLRELY 100
YLSESWDLDE AQFNTQDESN NLIEDLEIVS EVKREDFHMR PEESGAKVMG 150
PLLLREQTRR GDREIHCQDD VGQGGYQIPN NPDTIEFLDN DADFVLCVET 200
GGMRDRLVEN GFDDEYDSIV VHLGGQPARA TRRLTKRLHD ELDLPVVVFT 250
DGDPWSYRIY GSVAYGSIKS AHLSEYLATP EAQFIGIRPE DIVEYDLPTD 300
PLSDSDINAL ESELEDPRFQ TEFWEEQIEL QLDIGKKSEQ QALASRGLDF 350
VTDTYLPERL TEMGVL 366
Length:366
Mass (Da):41,726
Last modified:October 13, 2009 - v1
Checksum:i7CB5261BC4E2B5E1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001688 Genomic DNA. Translation: ACV48833.1.
RefSeqiWP_015763675.1. NC_013202.1.
YP_003178540.1. NC_013202.1.

Genome annotation databases

EnsemblBacteriaiACV48833; ACV48833; Hmuk_2727.
GeneIDi8412278.
KEGGihmu:Hmuk_2727.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001688 Genomic DNA. Translation: ACV48833.1 .
RefSeqi WP_015763675.1. NC_013202.1.
YP_003178540.1. NC_013202.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 485914.Hmuk_2727.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACV48833 ; ACV48833 ; Hmuk_2727 .
GeneIDi 8412278.
KEGGi hmu:Hmuk_2727.

Phylogenomic databases

eggNOGi COG1697.
HOGENOMi HOG000225930.
KOi K03166.
OMAi ENTFEDQ.

Enzyme and pathway databases

BioCyci HMUK485914:GCKD-2782-MONOMER.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
HAMAPi MF_00132. Top6A.
InterProi IPR002815. Spo11/TopoVI_A.
IPR013049. Spo11/TopoVI_A_N.
IPR004085. TopoVI_A.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
PANTHERi PTHR10848. PTHR10848. 1 hit.
Pfami PF04406. TP6A_N. 1 hit.
[Graphical view ]
PRINTSi PR01550. TOP6AFAMILY.
PR01552. TPISMRASE6A.
SUPFAMi SSF56726. SSF56726. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700874 / DSM 12286 / JCM 9738 / NCIMB 13541.

Entry informationi

Entry nameiC7NZR5_HALMD
AccessioniPrimary (citable) accession number: C7NZR5
Entry historyi
Integrated into UniProtKB/TrEMBL: October 13, 2009
Last sequence update: October 13, 2009
Last modified: September 3, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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