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Protein

Type 2 DNA topoisomerase 6 subunit A

Gene

top6A

Organism
Halomicrobium mukohataei (strain ATCC 700874 / DSM 12286 / JCM 9738 / NCIMB 13541) (Haloarcula mukohataei)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Relaxes both positive and negative superturns and exhibits a strong decatenase activity.UniRule annotation

Catalytic activityi

ATP-dependent breakage, passage and rejoining of double-stranded DNA.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei101 – 1011NucleophileUniRule annotation
Metal bindingi199 – 1991MagnesiumUniRule annotation
Metal bindingi251 – 2511MagnesiumUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA binding Source: UniProtKB-HAMAP
  3. DNA topoisomerase type II (ATP-hydrolyzing) activity Source: UniProtKB-HAMAP
  4. magnesium ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA catabolic process, endonucleolytic Source: InterPro
  2. DNA topological change Source: UniProtKB-HAMAP
  3. DNA unwinding involved in DNA replication Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase, TopoisomeraseUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, DNA-bindingUniRule annotation, MagnesiumUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciHMUK485914:GCKD-2782-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Type 2 DNA topoisomerase 6 subunit AUniRule annotation (EC:5.99.1.3UniRule annotation)
Alternative name(s):
Type II DNA topoisomerase VI subunit AUniRule annotation
Gene namesi
Name:top6AUniRule annotation
Ordered Locus Names:Hmuk_2727Imported
OrganismiHalomicrobium mukohataei (strain ATCC 700874 / DSM 12286 / JCM 9738 / NCIMB 13541) (Haloarcula mukohataei)Imported
Taxonomic identifieri485914 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalomicrobium
ProteomesiUP000001746: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. chromosome Source: InterPro
Complete GO annotation...

Interactioni

Subunit structurei

Homodimer. Heterotetramer of two Top6A and two Top6B chains.UniRule annotation

Protein-protein interaction databases

STRINGi485914.Hmuk_2727.

Family & Domainsi

Sequence similaritiesi

Belongs to the TOP6A family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1697.
HOGENOMiHOG000225930.
KOiK03166.
OMAiFTDGDPY.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
HAMAPiMF_00132. Top6A.
InterProiIPR002815. Spo11/TopoVI_A.
IPR013049. Spo11/TopoVI_A_N.
IPR004085. TopoVI_A.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR10848. PTHR10848. 1 hit.
PfamiPF04406. TP6A_N. 1 hit.
[Graphical view]
PRINTSiPR01550. TOP6AFAMILY.
PR01552. TPISMRASE6A.
SUPFAMiSSF56726. SSF56726. 1 hit.

Sequencei

Sequence statusi: Complete.

C7NZR5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSTDSNLNEA EAREQLLDLA ADFYDQFAEG DVPTMQIPTR TKSNIEYDED
60 70 80 90 100
KDVWVYGDRS STRSAKTVSG AQKLLKATYT IDFLAQQLEE DRSSTLRELY
110 120 130 140 150
YLSESWDLDE AQFNTQDESN NLIEDLEIVS EVKREDFHMR PEESGAKVMG
160 170 180 190 200
PLLLREQTRR GDREIHCQDD VGQGGYQIPN NPDTIEFLDN DADFVLCVET
210 220 230 240 250
GGMRDRLVEN GFDDEYDSIV VHLGGQPARA TRRLTKRLHD ELDLPVVVFT
260 270 280 290 300
DGDPWSYRIY GSVAYGSIKS AHLSEYLATP EAQFIGIRPE DIVEYDLPTD
310 320 330 340 350
PLSDSDINAL ESELEDPRFQ TEFWEEQIEL QLDIGKKSEQ QALASRGLDF
360
VTDTYLPERL TEMGVL
Length:366
Mass (Da):41,726
Last modified:October 13, 2009 - v1
Checksum:i7CB5261BC4E2B5E1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001688 Genomic DNA. Translation: ACV48833.1.
RefSeqiYP_003178540.1. NC_013202.1.

Genome annotation databases

EnsemblBacteriaiACV48833; ACV48833; Hmuk_2727.
GeneIDi8412278.
KEGGihmu:Hmuk_2727.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001688 Genomic DNA. Translation: ACV48833.1.
RefSeqiYP_003178540.1. NC_013202.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi485914.Hmuk_2727.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACV48833; ACV48833; Hmuk_2727.
GeneIDi8412278.
KEGGihmu:Hmuk_2727.

Phylogenomic databases

eggNOGiCOG1697.
HOGENOMiHOG000225930.
KOiK03166.
OMAiFTDGDPY.

Enzyme and pathway databases

BioCyciHMUK485914:GCKD-2782-MONOMER.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
HAMAPiMF_00132. Top6A.
InterProiIPR002815. Spo11/TopoVI_A.
IPR013049. Spo11/TopoVI_A_N.
IPR004085. TopoVI_A.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR10848. PTHR10848. 1 hit.
PfamiPF04406. TP6A_N. 1 hit.
[Graphical view]
PRINTSiPR01550. TOP6AFAMILY.
PR01552. TPISMRASE6A.
SUPFAMiSSF56726. SSF56726. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700874 / DSM 12286 / JCM 9738 / NCIMB 13541Imported.

Entry informationi

Entry nameiC7NZR5_HALMD
AccessioniPrimary (citable) accession number: C7NZR5
Entry historyi
Integrated into UniProtKB/TrEMBL: October 13, 2009
Last sequence update: October 13, 2009
Last modified: February 4, 2015
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.