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Protein

DNA ligase

Gene

lig

Organism
Halomicrobium mukohataei (strain ATCC 700874 / DSM 12286 / JCM 9738 / NCIMB 13541) (Haloarcula mukohataei)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei251ATPUniRule annotation1
Active sitei253N6-AMP-lysine intermediateUniRule annotation1
Binding sitei258ATPUniRule annotation1
Binding sitei273ATPUniRule annotation1
Binding sitei302ATPUniRule annotation1
Binding sitei342ATPUniRule annotation1
Binding sitei416ATPUniRule annotation1
Binding sitei422ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationImported
Biological processCell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation
LigandATP-bindingUniRule annotation, MagnesiumUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]UniRule annotation
Gene namesi
Name:ligUniRule annotation
Ordered Locus Names:Hmuk_2723Imported
OrganismiHalomicrobium mukohataei (strain ATCC 700874 / DSM 12286 / JCM 9738 / NCIMB 13541) (Haloarcula mukohataei)Imported
Taxonomic identifieri485914 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHaloarculaceaeHalomicrobium
Proteomesi

Interactioni

Protein-protein interaction databases

STRINGi485914.Hmuk_2723

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini330 – 457DNA_LIGASE_A3InterPro annotationAdd BLAST128

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01347 Archaea
COG1793 LUCA
HOGENOMiHOG000036008
KOiK10747
OMAiWLFEESY
OrthoDBiPOG093Z03L0

Family and domain databases

Gene3Di1.10.3260.10, 1 hit
HAMAPiMF_00407 DNA_ligase, 1 hit
InterProiView protein in InterPro
IPR022865 DNA_ligae_ATP-dep_bac/arc
IPR000977 DNA_ligase_ATP-dep
IPR012309 DNA_ligase_ATP-dep_C
IPR012310 DNA_ligase_ATP-dep_cent
IPR016059 DNA_ligase_ATP-dep_CS
IPR012308 DNA_ligase_ATP-dep_N
IPR036599 DNA_ligase_N_sf
IPR012340 NA-bd_OB-fold
PfamiView protein in Pfam
PF04679 DNA_ligase_A_C, 1 hit
PF01068 DNA_ligase_A_M, 1 hit
PF04675 DNA_ligase_A_N, 1 hit
SUPFAMiSSF117018 SSF117018, 1 hit
SSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00574 dnl1, 1 hit
PROSITEiView protein in PROSITE
PS00697 DNA_LIGASE_A1, 1 hit
PS50160 DNA_LIGASE_A3, 1 hit

Sequencei

Sequence statusi: Complete.

C7NZR1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEFAEFAATA AEIEGESADI ATTELVAGLL ADADEDLPIL TRLVQGRVFP
60 70 80 90 100
AYEATKLDIG PKLCYEALAR AAGRNVAVDD IEARVADVGE IGAVATELDL
110 120 130 140 150
GGQQGLAAFG AGSQSPLTVA EVADELAAIA SASGSGSHDT KVETLFGLFN
160 170 180 190 200
RASDAEARYL ARIVLSEMRI GVGEGTVRDA IAAAFDAPVD AVESALQVTN
210 220 230 240 250
DYGNVARVAR DEGADGLSDL ELTIGRPVKA MLAQAGTVTE ALEDWETAAV
260 270 280 290 300
EWKYDGARVQ VHDDGETVRL FSRNMEDVTD PLPEVVSAVE DAVDGPAILD
310 320 330 340 350
GEVVAVDGDG DPLPFQEVLR RFRRKHDVAR ASETVGVRLH AFDCLHADGR
360 370 380 390 400
DLLDAPLVDR RDALDAVLGD TDAVRSTFWL ADDTERIEDI ADEALAAGHE
410 420 430 440 450
GIMLKDPDST YSPGKRGKHW RKRKPDVETL DLVVTGAQWG EGRRATYLGT
460 470 480 490 500
FELSARTDDG YAPVGNVATG ITDEQLATLT ELLEPHVTRE TGQRVEIEPA
510 520 530 540 550
VVFEVGYEEI QRSSTYESGY ALRFPRFVEI RSDKAVADGD TLERVERLAA

RQG
Length:553
Mass (Da):59,337
Last modified:October 13, 2009 - v1
Checksum:i6627A5088B618211
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001688 Genomic DNA Translation: ACV48829.1
RefSeqiWP_015763671.1, NC_013202.1

Genome annotation databases

EnsemblBacteriaiACV48829; ACV48829; Hmuk_2723
GeneIDi8412274
KEGGihmu:Hmuk_2723

Similar proteinsi

Entry informationi

Entry nameiC7NZR1_HALMD
AccessioniPrimary (citable) accession number: C7NZR1
Entry historyiIntegrated into UniProtKB/TrEMBL: October 13, 2009
Last sequence update: October 13, 2009
Last modified: March 28, 2018
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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