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C7NZR1 (C7NZR1_HALMD) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 35. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length553 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity. HAMAP-Rule MF_00407

Catalytic activity

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m). HAMAP-Rule MF_00407

Cofactor

Divalent metal cations By similarity. HAMAP-Rule MF_00407

Sequence similarities

Belongs to the ATP-dependent DNA ligase family. HAMAP-Rule MF_00407 RuleBase RU004196

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site2531N6-AMP-lysine intermediate By similarity HAMAP-Rule MF_00407
Binding site2511ATP By similarity HAMAP-Rule MF_00407
Binding site2581ATP By similarity HAMAP-Rule MF_00407
Binding site2731ATP By similarity HAMAP-Rule MF_00407
Binding site3021ATP By similarity HAMAP-Rule MF_00407
Binding site3421ATP By similarity HAMAP-Rule MF_00407
Binding site4161ATP By similarity HAMAP-Rule MF_00407
Binding site4221ATP By similarity HAMAP-Rule MF_00407

Sequences

Sequence LengthMass (Da)Tools
C7NZR1 [UniParc].

Last modified October 13, 2009. Version 1.
Checksum: 6627A5088B618211

FASTA55359,337
        10         20         30         40         50         60 
MEFAEFAATA AEIEGESADI ATTELVAGLL ADADEDLPIL TRLVQGRVFP AYEATKLDIG 

        70         80         90        100        110        120 
PKLCYEALAR AAGRNVAVDD IEARVADVGE IGAVATELDL GGQQGLAAFG AGSQSPLTVA 

       130        140        150        160        170        180 
EVADELAAIA SASGSGSHDT KVETLFGLFN RASDAEARYL ARIVLSEMRI GVGEGTVRDA 

       190        200        210        220        230        240 
IAAAFDAPVD AVESALQVTN DYGNVARVAR DEGADGLSDL ELTIGRPVKA MLAQAGTVTE 

       250        260        270        280        290        300 
ALEDWETAAV EWKYDGARVQ VHDDGETVRL FSRNMEDVTD PLPEVVSAVE DAVDGPAILD 

       310        320        330        340        350        360 
GEVVAVDGDG DPLPFQEVLR RFRRKHDVAR ASETVGVRLH AFDCLHADGR DLLDAPLVDR 

       370        380        390        400        410        420 
RDALDAVLGD TDAVRSTFWL ADDTERIEDI ADEALAAGHE GIMLKDPDST YSPGKRGKHW 

       430        440        450        460        470        480 
RKRKPDVETL DLVVTGAQWG EGRRATYLGT FELSARTDDG YAPVGNVATG ITDEQLATLT 

       490        500        510        520        530        540 
ELLEPHVTRE TGQRVEIEPA VVFEVGYEEI QRSSTYESGY ALRFPRFVEI RSDKAVADGD 

       550 
TLERVERLAA RQG 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001688 Genomic DNA. Translation: ACV48829.1.
RefSeqYP_003178536.1. NC_013202.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING485914.Hmuk_2723.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACV48829; ACV48829; Hmuk_2723.
GeneID8412274.
KEGGhmu:Hmuk_2723.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1793.
HOGENOMHOG000036008.
KOK10747.
OMAGRPRPFQ.
ProtClustDBCLSK511253.

Enzyme and pathway databases

BioCycHMUK485914:GCKD-2778-MONOMER.

Family and domain databases

Gene3D1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPMF_00407. DNA_ligase.
InterProIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsTIGR00574. dnl1. 1 hit.
PROSITEPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameC7NZR1_HALMD
AccessionPrimary (citable) accession number: C7NZR1
Entry history
Integrated into UniProtKB/TrEMBL: October 13, 2009
Last sequence update: October 13, 2009
Last modified: February 19, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)