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C7NZR1

- C7NZR1_HALMD

UniProt

C7NZR1 - C7NZR1_HALMD

Protein

DNA ligase

Gene

lig

Organism
Halomicrobium mukohataei (strain ATCC 700874 / DSM 12286 / JCM 9738 / NCIMB 13541) (Haloarcula mukohataei)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 39 (01 Oct 2014)
      Sequence version 1 (13 Oct 2009)
      Previous versions | rss
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    Functioni

    DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

    Catalytic activityi

    ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

    Cofactori

    Divalent metal cations.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei251 – 2511ATPUniRule annotation
    Active sitei253 – 2531N6-AMP-lysine intermediateUniRule annotation
    Binding sitei258 – 2581ATPUniRule annotation
    Binding sitei273 – 2731ATPUniRule annotation
    Binding sitei302 – 3021ATPUniRule annotation
    Binding sitei342 – 3421ATPUniRule annotation
    Binding sitei416 – 4161ATPUniRule annotation
    Binding sitei422 – 4221ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. DNA binding Source: InterPro
    3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
    4. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. DNA ligation involved in DNA repair Source: InterPro
    4. DNA recombination Source: UniProtKB-HAMAP
    5. DNA replication Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    LigaseUniRule annotationImported

    Keywords - Biological processi

    Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciHMUK485914:GCKD-2778-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
    Alternative name(s):
    Polydeoxyribonucleotide synthase [ATP]UniRule annotation
    Gene namesi
    Name:ligUniRule annotation
    Ordered Locus Names:Hmuk_2723Imported
    OrganismiHalomicrobium mukohataei (strain ATCC 700874 / DSM 12286 / JCM 9738 / NCIMB 13541) (Haloarcula mukohataei)Imported
    Taxonomic identifieri485914 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalomicrobium
    ProteomesiUP000001746: Chromosome

    Interactioni

    Protein-protein interaction databases

    STRINGi485914.Hmuk_2723.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ATP-dependent DNA ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1793.
    HOGENOMiHOG000036008.
    KOiK10747.
    OMAiARVQVHK.

    Family and domain databases

    Gene3Di1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPiMF_00407. DNA_ligase.
    InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view]
    PfamiPF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsiTIGR00574. dnl1. 1 hit.
    PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C7NZR1-1 [UniParc]FASTAAdd to Basket

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    MEFAEFAATA AEIEGESADI ATTELVAGLL ADADEDLPIL TRLVQGRVFP    50
    AYEATKLDIG PKLCYEALAR AAGRNVAVDD IEARVADVGE IGAVATELDL 100
    GGQQGLAAFG AGSQSPLTVA EVADELAAIA SASGSGSHDT KVETLFGLFN 150
    RASDAEARYL ARIVLSEMRI GVGEGTVRDA IAAAFDAPVD AVESALQVTN 200
    DYGNVARVAR DEGADGLSDL ELTIGRPVKA MLAQAGTVTE ALEDWETAAV 250
    EWKYDGARVQ VHDDGETVRL FSRNMEDVTD PLPEVVSAVE DAVDGPAILD 300
    GEVVAVDGDG DPLPFQEVLR RFRRKHDVAR ASETVGVRLH AFDCLHADGR 350
    DLLDAPLVDR RDALDAVLGD TDAVRSTFWL ADDTERIEDI ADEALAAGHE 400
    GIMLKDPDST YSPGKRGKHW RKRKPDVETL DLVVTGAQWG EGRRATYLGT 450
    FELSARTDDG YAPVGNVATG ITDEQLATLT ELLEPHVTRE TGQRVEIEPA 500
    VVFEVGYEEI QRSSTYESGY ALRFPRFVEI RSDKAVADGD TLERVERLAA 550
    RQG 553
    Length:553
    Mass (Da):59,337
    Last modified:October 13, 2009 - v1
    Checksum:i6627A5088B618211
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001688 Genomic DNA. Translation: ACV48829.1.
    RefSeqiWP_015763671.1. NC_013202.1.
    YP_003178536.1. NC_013202.1.

    Genome annotation databases

    EnsemblBacteriaiACV48829; ACV48829; Hmuk_2723.
    GeneIDi8412274.
    KEGGihmu:Hmuk_2723.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001688 Genomic DNA. Translation: ACV48829.1 .
    RefSeqi WP_015763671.1. NC_013202.1.
    YP_003178536.1. NC_013202.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 485914.Hmuk_2723.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACV48829 ; ACV48829 ; Hmuk_2723 .
    GeneIDi 8412274.
    KEGGi hmu:Hmuk_2723.

    Phylogenomic databases

    eggNOGi COG1793.
    HOGENOMi HOG000036008.
    KOi K10747.
    OMAi ARVQVHK.

    Enzyme and pathway databases

    BioCyci HMUK485914:GCKD-2778-MONOMER.

    Family and domain databases

    Gene3Di 1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPi MF_00407. DNA_ligase.
    InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view ]
    Pfami PF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsi TIGR00574. dnl1. 1 hit.
    PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700874 / DSM 12286 / JCM 9738 / NCIMB 13541Imported.

    Entry informationi

    Entry nameiC7NZR1_HALMD
    AccessioniPrimary (citable) accession number: C7NZR1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 13, 2009
    Last sequence update: October 13, 2009
    Last modified: October 1, 2014
    This is version 39 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3