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C7NZR1

- C7NZR1_HALMD

UniProt

C7NZR1 - C7NZR1_HALMD

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Protein

DNA ligase

Gene

lig

Organism
Halomicrobium mukohataei (strain ATCC 700874 / DSM 12286 / JCM 9738 / NCIMB 13541) (Haloarcula mukohataei)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

Note: Divalent metal cations.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei251 – 2511ATPUniRule annotation
Active sitei253 – 2531N6-AMP-lysine intermediateUniRule annotation
Binding sitei258 – 2581ATPUniRule annotation
Binding sitei273 – 2731ATPUniRule annotation
Binding sitei302 – 3021ATPUniRule annotation
Binding sitei342 – 3421ATPUniRule annotation
Binding sitei416 – 4161ATPUniRule annotation
Binding sitei422 – 4221ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. DNA biosynthetic process Source: InterPro
  4. DNA ligation involved in DNA repair Source: InterPro
  5. DNA recombination Source: UniProtKB-HAMAP
  6. DNA replication Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotation

Keywords - Biological processi

Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciHMUK485914:GCKD-2778-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]UniRule annotation
Gene namesi
Name:ligUniRule annotation
Ordered Locus Names:Hmuk_2723Imported
OrganismiHalomicrobium mukohataei (strain ATCC 700874 / DSM 12286 / JCM 9738 / NCIMB 13541) (Haloarcula mukohataei)Imported
Taxonomic identifieri485914 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalomicrobium
ProteomesiUP000001746: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi485914.Hmuk_2723.

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1793.
HOGENOMiHOG000036008.
KOiK10747.
OMAiARVQVHK.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C7NZR1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEFAEFAATA AEIEGESADI ATTELVAGLL ADADEDLPIL TRLVQGRVFP
60 70 80 90 100
AYEATKLDIG PKLCYEALAR AAGRNVAVDD IEARVADVGE IGAVATELDL
110 120 130 140 150
GGQQGLAAFG AGSQSPLTVA EVADELAAIA SASGSGSHDT KVETLFGLFN
160 170 180 190 200
RASDAEARYL ARIVLSEMRI GVGEGTVRDA IAAAFDAPVD AVESALQVTN
210 220 230 240 250
DYGNVARVAR DEGADGLSDL ELTIGRPVKA MLAQAGTVTE ALEDWETAAV
260 270 280 290 300
EWKYDGARVQ VHDDGETVRL FSRNMEDVTD PLPEVVSAVE DAVDGPAILD
310 320 330 340 350
GEVVAVDGDG DPLPFQEVLR RFRRKHDVAR ASETVGVRLH AFDCLHADGR
360 370 380 390 400
DLLDAPLVDR RDALDAVLGD TDAVRSTFWL ADDTERIEDI ADEALAAGHE
410 420 430 440 450
GIMLKDPDST YSPGKRGKHW RKRKPDVETL DLVVTGAQWG EGRRATYLGT
460 470 480 490 500
FELSARTDDG YAPVGNVATG ITDEQLATLT ELLEPHVTRE TGQRVEIEPA
510 520 530 540 550
VVFEVGYEEI QRSSTYESGY ALRFPRFVEI RSDKAVADGD TLERVERLAA

RQG
Length:553
Mass (Da):59,337
Last modified:October 13, 2009 - v1
Checksum:i6627A5088B618211
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001688 Genomic DNA. Translation: ACV48829.1.
RefSeqiYP_003178536.1. NC_013202.1.

Genome annotation databases

EnsemblBacteriaiACV48829; ACV48829; Hmuk_2723.
GeneIDi8412274.
KEGGihmu:Hmuk_2723.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001688 Genomic DNA. Translation: ACV48829.1 .
RefSeqi YP_003178536.1. NC_013202.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 485914.Hmuk_2723.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACV48829 ; ACV48829 ; Hmuk_2723 .
GeneIDi 8412274.
KEGGi hmu:Hmuk_2723.

Phylogenomic databases

eggNOGi COG1793.
HOGENOMi HOG000036008.
KOi K10747.
OMAi ARVQVHK.

Enzyme and pathway databases

BioCyci HMUK485914:GCKD-2778-MONOMER.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPi MF_00407. DNA_ligase.
InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700874 / DSM 12286 / JCM 9738 / NCIMB 13541Imported.

Entry informationi

Entry nameiC7NZR1_HALMD
AccessioniPrimary (citable) accession number: C7NZR1
Entry historyi
Integrated into UniProtKB/TrEMBL: October 13, 2009
Last sequence update: October 13, 2009
Last modified: November 26, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3