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C7NXJ4 (C7NXJ4_HALMD) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 29. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phosphoribosylamine--glycine ligase HAMAP-Rule MF_00138
EC=6.3.4.13 HAMAP-Rule MF_00138
Alternative name(s):
GARS HAMAP-Rule MF_00138
Glycinamide ribonucleotide synthetase HAMAP-Rule MF_00138
Phosphoribosylglycinamide synthetase HAMAP-Rule MF_00138
Gene names
Name:purD HAMAP-Rule MF_00138
Ordered Locus Names:Hmuk_2316 EMBL ACV48428.1
OrganismHalomicrobium mukohataei (strain ATCC 700874 / DSM 12286 / JCM 9738 / NCIMB 13541) (Haloarcula mukohataei) [Complete proteome] [HAMAP] EMBL ACV48428.1
Taxonomic identifier485914 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Halobacteria › Halobacteriales › Halobacteriaceae › Halomicrobium ›

Protein attributes

Sequence length446 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 5-phospho-D-ribosylamine + glycine = ADP + phosphate + N(1)-(5-phospho-D-ribosyl)glycinamide. HAMAP-Rule MF_00138

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00138

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2. HAMAP-Rule MF_00138

Sequence similarities

Belongs to the GARS family. HAMAP-Rule MF_00138

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00138

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain110 – 311202ATP-grasp By similarity HAMAP-Rule MF_00138
Nucleotide binding137 – 19357ATP By similarity HAMAP-Rule MF_00138

Sites

Metal binding2691Magnesium or manganese 1 By similarity HAMAP-Rule MF_00138
Metal binding2811Magnesium or manganese 1 By similarity HAMAP-Rule MF_00138
Metal binding2811Magnesium or manganese 2 By similarity HAMAP-Rule MF_00138
Metal binding2831Magnesium or manganese 2 By similarity HAMAP-Rule MF_00138

Sequences

Sequence LengthMass (Da)Tools
C7NXJ4 [UniParc].

Last modified October 13, 2009. Version 1.
Checksum: 83579C710A8AB20C

FASTA44647,927
        10         20         30         40         50         60 
MTETVVLIGG GGREHAIARS LAESEARLYA CAGNRNPGIA ALADGFETLD TTNPTAVRTY 

        70         80         90        100        110        120 
ADEVDATLAV VGPEAALEAG VADALDEAGV YTFGPRQDAA RIETDKAFQR RFMREHDIPG 

       130        140        150        160        170        180 
CPDFETFDDM AAACAYIDDY DGDLAVKPAG LTGGKGVRVI GDQVTAEEAK EHLRSADYDR 

       190        200        210        220        230        240 
VVLEERLVGE EFTVQAFVAN GQLRVTPAVQ DHKRAYEGDE GPNTGGMGSY SDAGLELPFM 

       250        260        270        280        290        300 
SEDDYMEAVD VLRAVVDALD DYKGVLYGQF MLTADGIKVV EFNARFGDPE AMNTLPVLNT 

       310        320        330        340        350        360 
DFLDVLTAAR EDEPLPQLSF APKATVCKYA VPEGYPTEPK AGAKVKIDED SVAKATERSS 

       370        380        390        400        410        420 
GDEPRDSAGD ALLFYASVDE RDDGIYTTTS RSFAVVGLAE TITEAEEIAE AALDAAGEDG 

       430        440 
VRMRHDIGKP DLVQQRIDHV NELRGE

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001688 Genomic DNA. Translation: ACV48428.1.
RefSeqYP_003178135.1. NC_013202.1.

3D structure databases

ProteinModelPortalC7NXJ4.
ModBaseSearch...

Protein-protein interaction databases

STRING485914.Hmuk_2316.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACV48428; ACV48428; Hmuk_2316.
GeneID8411857.
KEGGhmu:Hmuk_2316.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0151.
HOGENOMHOG000033464.
KOK01945.
OMAEPLFAGV.
ProtClustDBCLSK511372.

Enzyme and pathway databases

UniPathwayUPA00074; UER00125.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
3.90.600.10. 1 hit.
HAMAPMF_00138. GARS.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR016185. PreATP-grasp_dom.
IPR020561. PRibGlycinamid_synth_ATP-grasp.
IPR000115. PRibGlycinamide_synth.
IPR020560. PRibGlycinamide_synth_C-dom.
IPR020559. PRibGlycinamide_synth_CS.
IPR020562. PRibGlycinamide_synth_N.
IPR011054. Rudment_hybrid_motif.
[Graphical view]
PfamPF01071. GARS_A. 1 hit.
PF02843. GARS_C. 1 hit.
PF02844. GARS_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. PreATP-grasp-like. 1 hit.
SSF51246. Rudmnt_hyb_motif. 1 hit.
TIGRFAMsTIGR00877. purD. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00184. GARS. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameC7NXJ4_HALMD
AccessionPrimary (citable) accession number: C7NXJ4
Entry history
Integrated into UniProtKB/TrEMBL: October 13, 2009
Last sequence update: October 13, 2009
Last modified: May 1, 2013
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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