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Protein

Probable tRNA pseudouridine synthase D

Gene

truD

Organism
Halomicrobium mukohataei (strain ATCC 700874 / DSM 12286 / JCM 9738 / NCIMB 13541) (Haloarcula mukohataei)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.UniRule annotation

Catalytic activityi

tRNA uridine(13) = tRNA pseudouridine(13).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei93 – 931NucleophileUniRule annotation

GO - Molecular functioni

  1. pseudouridine synthase activity Source: UniProtKB-HAMAP
  2. RNA binding Source: InterPro

GO - Biological processi

  1. tRNA pseudouridine synthesis Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotation

Keywords - Biological processi

tRNA processingUniRule annotation

Enzyme and pathway databases

BioCyciHMUK485914:GCKD-17-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable tRNA pseudouridine synthase DUniRule annotation (EC:5.4.99.27UniRule annotation)
Alternative name(s):
tRNA pseudouridine(13) synthaseUniRule annotation
tRNA pseudouridylate synthase DUniRule annotation
tRNA-uridine isomerase DUniRule annotation
Gene namesi
Name:truDUniRule annotation
Ordered Locus Names:Hmuk_0017Imported
OrganismiHalomicrobium mukohataei (strain ATCC 700874 / DSM 12286 / JCM 9738 / NCIMB 13541) (Haloarcula mukohataei)Imported
Taxonomic identifieri485914 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalomicrobium
ProteomesiUP000001746: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi485914.Hmuk_0017.

Structurei

3D structure databases

ProteinModelPortaliC7NVQ3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini176 – 408233TRUDUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the pseudouridine synthase TruD family.UniRule annotation
Contains 1 TRUD domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG0585.
HOGENOMiHOG000224849.
KOiK06176.
OMAiLRYERAM.

Family and domain databases

HAMAPiMF_01082. TruD.
InterProiIPR020103. PsdUridine_synth_cat_dom.
IPR001656. PsdUridine_synth_TruD.
IPR020119. PsdUridine_synth_TruD_CS.
IPR011760. PsdUridine_synth_TruD_insert.
[Graphical view]
PANTHERiPTHR13326. PTHR13326. 1 hit.
PfamiPF01142. TruD. 1 hit.
[Graphical view]
SUPFAMiSSF55120. SSF55120. 2 hits.
TIGRFAMsiTIGR00094. tRNA_TruD_broad. 1 hit.
PROSITEiPS50984. TRUD. 1 hit.
PS01268. UPF0024. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C7NVQ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRPAQPIEQA VGMRYYVSDG DGIGGRLRAS PEDFAVRELE AFEAEPADAD
60 70 80 90 100
SGAYAHLVVR ATLHNWDTND FASALSDRLG ISRERVSWAG TKDKRAVTTQ
110 120 130 140 150
LFSIADADAA DVPEIDGAEI DVVGRAGRPV LFGDLAGNAF EIIVREVDRP
160 170 180 190 200
DGVDGITEQL REFAGSADAA DEPTVAVPNY FGQQRFGSKR PITHEVGLAI
210 220 230 240 250
VRNDWEGAVM AYLGNPNERE PEATQAARAY VEETHDWEGA LERFPRALGY
260 270 280 290 300
ERALCHSLAD ADDASPAAFR SALETLPTNL QTLFVNAAQS YLFNRVLSER
310 320 330 340 350
LDRGLPFDRP VAGDVVCFAD SDAPDGLPLP DTDRTQRVTA GRVDTVERHC
360 370 380 390 400
ERGRAFVTAP LVGTETELAE GEPGEIERAV LADAELEPTD FALPGEFDSS
410 420 430 440
GTRRAVQVRS QIDVRRRDGD AVEFAFSLPK GSYATVLLRE YLKRDPAQL
Length:449
Mass (Da):48,978
Last modified:October 13, 2009 - v1
Checksum:i543E506E26DE3C6E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001688 Genomic DNA. Translation: ACV46168.1.
RefSeqiYP_003175875.1. NC_013202.1.

Genome annotation databases

EnsemblBacteriaiACV46168; ACV46168; Hmuk_0017.
GeneIDi8409513.
KEGGihmu:Hmuk_0017.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001688 Genomic DNA. Translation: ACV46168.1.
RefSeqiYP_003175875.1. NC_013202.1.

3D structure databases

ProteinModelPortaliC7NVQ3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi485914.Hmuk_0017.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACV46168; ACV46168; Hmuk_0017.
GeneIDi8409513.
KEGGihmu:Hmuk_0017.

Phylogenomic databases

eggNOGiCOG0585.
HOGENOMiHOG000224849.
KOiK06176.
OMAiLRYERAM.

Enzyme and pathway databases

BioCyciHMUK485914:GCKD-17-MONOMER.

Family and domain databases

HAMAPiMF_01082. TruD.
InterProiIPR020103. PsdUridine_synth_cat_dom.
IPR001656. PsdUridine_synth_TruD.
IPR020119. PsdUridine_synth_TruD_CS.
IPR011760. PsdUridine_synth_TruD_insert.
[Graphical view]
PANTHERiPTHR13326. PTHR13326. 1 hit.
PfamiPF01142. TruD. 1 hit.
[Graphical view]
SUPFAMiSSF55120. SSF55120. 2 hits.
TIGRFAMsiTIGR00094. tRNA_TruD_broad. 1 hit.
PROSITEiPS50984. TRUD. 1 hit.
PS01268. UPF0024. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700874 / DSM 12286 / JCM 9738 / NCIMB 13541Imported.

Entry informationi

Entry nameiC7NVQ3_HALMD
AccessioniPrimary (citable) accession number: C7NVQ3
Entry historyi
Integrated into UniProtKB/TrEMBL: October 13, 2009
Last sequence update: October 13, 2009
Last modified: March 4, 2015
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.