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C7NQ49 (C7NQ49_HALUD) Unreviewed, UniProtKB/TrEMBL

Last modified November 16, 2011. Version 14. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
DNA polymerase II large subunit HAMAP MF_00324
Short name=Pol II HAMAP MF_00324
EC=2.7.7.7 HAMAP MF_00324
Gene names
Name:polC HAMAP MF_00324
Ordered Locus Names:Huta_1619
OrganismHalorhabdus utahensis (strain DSM 12940 / JCM 11049 / AX-2) [Complete proteome] [HAMAP]
Taxonomic identifier519442 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Halobacteria › Halobacteriales › Halobacteriaceae › Halorhabdus

Protein attributes

Sequence length1193 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase By similarity. HAMAP MF_00324

Catalytic activity

Degradation of single-stranded DNA. It acts progressively in a 3'- to 5'-direction, releasing nucleoside 5'-phosphates. HAMAP MF_00324

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). HAMAP MF_00324

Subunit structure

Heterodimer of a large subunit and a small subunit By similarity. HAMAP MF_00324

Sequence similarities

Belongs to the archaeal DNA polymerase II family. HAMAP MF_00324

Sequences

Sequence LengthMass (Da)Tools
C7NQ49 [UniParc].

Last modified October 13, 2009. Version 1.
Checksum: 82ADB55D65625333

FASTA1,193131,423
        10         20         30         40         50         60 
MRDADERYFA RLEDELDTAM DVARSARERG GDPTTDVEIP VAKDMADRVE NILGIDGVAE 

        70         80         90        100        110        120 
RVRDLEGEMS REEAALALVE DFVAGTVGDY DTKAGKIEGA VRTAVALLTE GVVAAPIEGI 

       130        140        150        160        170        180 
DRVEILDNDD GTQFVNVYYA GPIRSAGGTA QALSVLVADY ARTLLDIDEY HARDEEIGRY 

       190        200        210        220        230        240 
VEEIELYDED TGLQYSPKEK ETRHITDHMP IMLDGEATGG EEVSGYRDLE RVDSNSARGG 

       250        260        270        280        290        300 
MCLVLAEGIA LKAPKIQRYT RQLDDVEWPW LQDLIDGTIG ADESEDETGG EEDEDGSADG 

       310        320        330        340        350        360 
ERDTQDDDAS TVDGPPRAEP SKKYLRDLIA GRPVFSHPSE SGGFRLRYGR ARNHGNATAG 

       370        380        390        400        410        420 
VHPATMHLVD DFLATGTQIK TERPGKAAGV VPVDTIEGPT VRLANGDVRR IDDPEEAKEV 

       430        440        450        460        470        480 
RNGVESVLDL GEYLVNYGEF IENNHPLAPA SYTVEWWVQE FEAAGADVQA MTDSVEIDLD 

       490        500        510        520        530        540 
DPTPSRALQW AREYDAPLHP KYTYVYHDVS VEAIDALADA IADGEIVTGD GATAEPGDHA 

       550        560        570        580        590        600 
DRAGTATGDL VLPRSEIARR TLESLLVEHT QTDASLIVPT WRPLVETLGF NDDLTRPWTL 

       610        620        630        640        650        660 
SDLSEAARTY DDGENAIEAV NEIAPFDVRE RAPTRIGNRM GRPEKSEERE LSPAVHTLFP 

       670        680        690        700        710        720 
IGEAGGNQRD VAKAAGHADE MGDAPGEVEL EVGRRRCTDC ATETYQARCP DCNGITETIY 

       730        740        750        760        770        780 
VCPDCDREVD PDESGRAECP RCETIASPTR MTTIDVGEVY QQAMDSVGER EVAFDVLKGV 

       790        800        810        820        830        840 
KGLTSKEKMP EPMEKGVLRA KHDISAFKDG TVRYDMTDLP VTSVRPAELD VTVEQFRELG 

       850        860        870        880        890        900 
YEADIQGDPL IHDDQLVELN VQDVVLSDGA AEHMLKTAAF IDDLLESYYG LDPYYELEDR 

       910        920        930        940        950        960 
DDLVGELVFG MAPHTSAATV GRVVGFTSAA VGYAHPYFHA AKRRNCDGDE DCVMLLLDGL 

       970        980        990       1000       1010       1020 
LNFSVKYLPN QRGGRMDAPL VMSSRIDPAE IDDEAHNIDI VEQYPLELYE ATREMAHPED 

      1030       1040       1050       1060       1070       1080 
VDVKIAEDTL GTDEEYTGFA HTHDTSNIAL GPDLSAYKTL GSMEDKMDAQ LEISRKLRAV 

      1090       1100       1110       1120       1130       1140 
DETDVAERII EYHFLPDLIG NLRAFSRQDV RCLGCGEKYR RMPLTGTCRE CGGDVNLTVH 

      1150       1160       1170       1180       1190 
EGSVNKYIDT ATRVAEEFGA REYTKQRLEI LDRAIKRVFE DDTSRQTGIG DFM

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001687 Genomic DNA. Translation: ACV11793.1.
RefSeqYP_003130526.1. NC_013158.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGC7NQ49.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID8383898.
GenomeReviewsGene locus Huta_1619 in contig CP001687_GR.
KEGGhut:Huta_1619.

Organism-specific databases

CMRSearch...

Phylogenomic databases

OMANCDGDED.
ProtClustDBPRK04023.

Family and domain databases

HAMAPMF_00324. DNApol_II_L_arch.
[Tree]
InterProIPR004475. PolC_DP2.
IPR016033. PolC_DP2_N.
[Graphical view]
KOK02322.
PfamPF03833. PolC_DP2. 1 hit.
[Graphical view]
PIRSFPIRSF016275. PolC_DP2. 1 hit.
TIGRFAMsTIGR00354. PolC. 1 hit.
ProtoNetSearch...

Entry information

Entry nameC7NQ49_HALUD
AccessionPrimary (citable) accession number: C7NQ49
Entry history
Integrated into UniProtKB/TrEMBL: October 13, 2009
Last sequence update: October 13, 2009
Last modified: November 16, 2011
This is version 14 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info