C7NNE7 (C7NNE7_HALUD) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Gamma-glutamyl phosphate reductase HAMAP MF_00412
Short name=GPR HAMAP MF_00412
EC=1.2.1.41 HAMAP MF_00412

Alternative name(s):
Glutamate-5-semialdehyde dehydrogenase HAMAP MF_00412
Glutamyl-gamma-semialdehyde dehydrogenase HAMAP MF_00412

Gene names

Name:	proA HAMAP MF_00412
Ordered Locus Names:	Huta_1371

Organism

Halorhabdus utahensis (strain DSM 12940 / JCM 11049 / AX-2) [Complete proteome] [HAMAP]

Taxonomic identifier

519442 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Halobacteria › Halobacteriales › Halobacteriaceae › Halorhabdus

Protein attributes

Sequence length	443 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the NADPH dependent reduction of L-gamma-glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate By similarity. HAMAP MF_00412
Catalytic activity	L-glutamate 5-semialdehyde + phosphate + NADP+ = L-glutamyl 5-phosphate + NADPH. HAMAP MF_00412
Pathway	Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2. HAMAP MF_00412
Subcellular location	Cytoplasm By similarity HAMAP MF_00412.
Sequence similarities	Belongs to the gamma-glutamyl phosphate reductase family. HAMAP MF_00412

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Proline biosynthesis HAMAP MF_00412
Cellular component	Cytoplasm HAMAP MF_00412
Ligand	NADP HAMAP MF_00412
Molecular function	Oxidoreductase HAMAP MF_00412
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	proline biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	NADP binding Inferred from electronic annotation. Source: InterPro glutamate-5-semialdehyde dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	C7NNE7 [UniParc]. Last modified October 13, 2009. Version 1. Checksum: FABA1CA084BEB0FC	FASTA	443	48,197
	10 20 30 40 50 60 MTDTDTESKV EAAEAAALEL ANVSDADRRA ALEAIATAID DHREEVIAVN DEDVEAGEEL 70 80 90 100 110 120 LEAGEYTQAL VDRLKLDDAK MDSIVEMVES VAAMDDPLGE TLEARHLDDD LDLYKVAVPI 130 140 150 160 170 180 GVIGTVFESR PDALVQIAAL ALKSGNAVIL KGGSEASESN RELFEIIREA AQDVEAIPEG 190 200 210 220 230 240 WVQLIEAREA VDTVLEMDEY IDLLMPRGSS AFVSYVQENT QIPVLGHTEG VCHVYVDSEA 250 260 270 280 290 300 DLDEAVEVAY DAKVQYTAVC NAVETLLVHD DVAEEFLPTM ADRYAEADVE LRGDDRTREI 310 320 330 340 350 360 LADSGLDVLE ATEEDWRTEY GDLILSIKVV DSLVDAIDHV NTNGSKHTES ILTEDDAKAR 370 380 390 400 410 420 KFMTGVDAAS VFHNASTRFA DGYRYGLGAE VGISTGKIHA RGPVGLEGLT TYKYYLEGDG 430 440 HLVASYAGED AIPFSHEDFD GEW

References

[1]

"Complete genome sequence of Halorhabdus utahensis type strain (AX-2)." Anderson I., Tindall B.J., Pomrenke H., Goker M., Lapidus A., Nolan M., Copeland A., Glavina Del Rio T., Chen F., Tice H., Cheng J.F., Lucas S., Chertkov O., Bruce D., Brettin T., Detter J.C., Han C., Goodwin L. , Land M., Hauser L., Chang Y.J., Jeffries C.D., Pitluck S., Pati A., Mavromatis K., Ivanova N., Ovchinnikova G., Chen A., Palaniappan K., Chain P., Rohde M., Bristow J., Eisen J.A., Markowitz V., Hugenholtz P., Kyrpides N.C., Klenk H.P. Stand. Genomic Sci. 1:218-225(2009) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 12940 / JCM 11049 / AX-2.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001687 Genomic DNA. Translation: ACV11547.1.
RefSeq	YP_003130280.1. NC_013158.1.
3D structure databases
ProteinModelPortal	C7NNE7.
ModBase	Search...
Protein-protein interaction databases
STRING	C7NNE7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	8383650.
GenomeReviews	Gene locus Huta_1371 in contig CP001687_GR.
KEGG	hut:Huta_1371.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	QYPAACN.
ProtClustDB	PRK00197.
Family and domain databases
HAMAP	MF_00412. ProA. [Tree]
InterPro	IPR016161. Ald_DH/histidinol_DH. IPR016163. Ald_DH_C. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH_dom. IPR000965. G-glutamylP_reductase. IPR012134. Glu-5-SA_DH. [Graphical view]
Gene3D	G3DSA:3.40.309.10. Aldehyde_dehydrogenase_C. 1 hit. G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 2 hits.
KO	K00147.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
PIRSF	PIRSF000151. GPR. 1 hit.
SUPFAM	SSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
TIGRFAMs	TIGR00407. ProA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

C7NNE7_HALUD

Accession

Primary (citable) accession number: C7NNE7

Entry history

Integrated into UniProtKB/TrEMBL:	October 13, 2009
Last sequence update:	October 13, 2009
Last modified:	November 16, 2011
This is version 19 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)