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C7NJH3

- C7NJH3_KYTSD

UniProt

C7NJH3 - C7NJH3_KYTSD

Protein

Kynureninase

Gene

Ksed_02180

Organism
Kytococcus sedentarius (strain ATCC 14392 / DSM 20547 / CCM 314 / 541) (Micrococcus sedentarius)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 30 (01 Oct 2014)
      Sequence version 1 (13 Oct 2009)
      Previous versions | rss
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    Functioni

    Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.UniRule annotation

    Catalytic activityi

    L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine.UniRule annotation
    L-kynurenine + H2O = anthranilate + L-alanine.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. kynureninase activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. L-kynurenine catabolic process Source: UniProtKB-UniPathway
    2. NAD biosynthetic process Source: UniProtKB-UniPathway
    3. tryptophan catabolic process Source: InterPro

    Keywords - Molecular functioni

    HydrolaseUniRule annotation

    Keywords - Biological processi

    Pyridine nucleotide biosynthesisUniRule annotation

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotation

    Enzyme and pathway databases

    BioCyciKSED478801:GI4L-217-MONOMER.
    UniPathwayiUPA00253; UER00329.
    UPA00334; UER00455.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    KynureninaseUniRule annotation (EC:3.7.1.3UniRule annotation)
    Gene namesi
    Ordered Locus Names:Ksed_02180Imported
    OrganismiKytococcus sedentarius (strain ATCC 14392 / DSM 20547 / CCM 314 / 541) (Micrococcus sedentarius)Imported
    Taxonomic identifieri478801 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeDermacoccaceaeKytococcus
    ProteomesiUP000006666: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: InterPro

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi478801.Ksed_02180.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the kynureninase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG3844.
    HOGENOMiHOG000242437.
    KOiK01556.
    OMAiHVAYRSA.
    OrthoDBiEOG6N67XP.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProiIPR000192. Aminotrans_V/Cys_dSase.
    IPR010111. Kynureninase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PANTHERiPTHR14084. PTHR14084. 1 hit.
    PfamiPF00266. Aminotran_5. 1 hit.
    [Graphical view]
    PIRSFiPIRSF038800. KYNU. 1 hit.
    SUPFAMiSSF53383. SSF53383. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    C7NJH3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTSLNTPDAV RARAAELDAA DELAHLRERF VPMDACGTVG GAVLSYLDGN    50
    SLGRPLKSAA EALDRIVSEA WGTRLIRSWD EQWMELPLRL GDRLGEVALG 100
    AAPGQVVVAD STTVMLYKLL RAGLAAAQAA DPARREIVVD TGNFPTDRYV 150
    AEGIAAECDA ELVWIEADAG TGVTTEQVRD AVGSATAAVV LSHVAYRSAY 200
    VADLPAITQV VHEAGGLVLW DLCHSAGVVP VDLDEHEVDL AVGCSYKYLN 250
    GGPGAPAFGY VAARHQERMT QPIQGWMGHA EPFVMGPGYQ PSPGMRRFIS 300
    GTPPVLGMVP LGEMVELVAD VGLPALTAKA TALTEFAIEV TDGLLTRHGV 350
    SVDSPRDPAQ RGGHVTLGHP AAREVIAALW EQGVIPDFRE PDGVRLGMSP 400
    ASTSFAEVAE GLLLLDAELE RAGRG 425
    Length:425
    Mass (Da):44,834
    Last modified:October 13, 2009 - v1
    Checksum:i790BCC150CBAE80E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001686 Genomic DNA. Translation: ACV05303.1.
    RefSeqiWP_012801721.1. NC_013169.1.
    YP_003148068.1. NC_013169.1.

    Genome annotation databases

    EnsemblBacteriaiACV05303; ACV05303; Ksed_02180.
    GeneIDi8371730.
    KEGGikse:Ksed_02180.
    PATRICi22190139. VBIKytSed14067_0204.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001686 Genomic DNA. Translation: ACV05303.1 .
    RefSeqi WP_012801721.1. NC_013169.1.
    YP_003148068.1. NC_013169.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 478801.Ksed_02180.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACV05303 ; ACV05303 ; Ksed_02180 .
    GeneIDi 8371730.
    KEGGi kse:Ksed_02180.
    PATRICi 22190139. VBIKytSed14067_0204.

    Phylogenomic databases

    eggNOGi COG3844.
    HOGENOMi HOG000242437.
    KOi K01556.
    OMAi HVAYRSA.
    OrthoDBi EOG6N67XP.

    Enzyme and pathway databases

    UniPathwayi UPA00253 ; UER00329 .
    UPA00334 ; UER00455 .
    BioCyci KSED478801:GI4L-217-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProi IPR000192. Aminotrans_V/Cys_dSase.
    IPR010111. Kynureninase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    PANTHERi PTHR14084. PTHR14084. 1 hit.
    Pfami PF00266. Aminotran_5. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF038800. KYNU. 1 hit.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 14392 / DSM 20547 / CCM 314 / 541Imported.

    Entry informationi

    Entry nameiC7NJH3_KYTSD
    AccessioniPrimary (citable) accession number: C7NJH3
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 13, 2009
    Last sequence update: October 13, 2009
    Last modified: October 1, 2014
    This is version 30 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3