C7NJH3 (C7NJH3_KYTSD) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Kynureninase PIRNR PIRNR038800
EC=3.7.1.3 PIRNR PIRNR038800

Gene names

Ordered Locus Names:

Ksed_02180

Organism

Kytococcus sedentarius (strain ATCC 14392 / DSM 20547 / CCM 314 / 541) (Micrococcus sedentarius) [Complete proteome] [HAMAP]

Taxonomic identifier

478801 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Actinobacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Dermacoccaceae › Kytococcus › Kytococcus sedentarius

Protein attributes

Sequence length	425 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively By similarity. PIRNR PIRNR038800
Catalytic activity	L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine. PIRNR PIRNR038800 L-kynurenine + H2O = anthranilate + L-alanine. PIRNR PIRNR038800
Cofactor	Pyridoxal phosphate By similarity. PIRNR PIRNR038800
Pathway	Amino-acid degradation; L-kynurenine degradation; L-alanine and anthranilate from L-kynurenine: step 1/1. PIRNR PIRNR038800 Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 2/3. PIRNR PIRNR038800
Subunit structure	Homodimer By similarity. PIRNR PIRNR038800
Sequence similarities	Belongs to the kynureninase family. PIRNR PIRNR038800

Ontologies

Keywords
Biological process	Pyridine nucleotide biosynthesis PIRNR PIRNR038800
Ligand	Pyridoxal phosphate PIRNR PIRNR038800
Molecular function	Hydrolase PIRNR PIRNR038800
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	L-kynurenine catabolic process Inferred from electronic annotation. Source: UniProtKB-UniPathway NAD biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway tryptophan catabolic process Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular_function	kynureninase activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	C7NJH3 [UniParc]. Last modified October 13, 2009. Version 1. Checksum: 790BCC150CBAE80E	FASTA	425	44,834
	10 20 30 40 50 60 MTSLNTPDAV RARAAELDAA DELAHLRERF VPMDACGTVG GAVLSYLDGN SLGRPLKSAA 70 80 90 100 110 120 EALDRIVSEA WGTRLIRSWD EQWMELPLRL GDRLGEVALG AAPGQVVVAD STTVMLYKLL 130 140 150 160 170 180 RAGLAAAQAA DPARREIVVD TGNFPTDRYV AEGIAAECDA ELVWIEADAG TGVTTEQVRD 190 200 210 220 230 240 AVGSATAAVV LSHVAYRSAY VADLPAITQV VHEAGGLVLW DLCHSAGVVP VDLDEHEVDL 250 260 270 280 290 300 AVGCSYKYLN GGPGAPAFGY VAARHQERMT QPIQGWMGHA EPFVMGPGYQ PSPGMRRFIS 310 320 330 340 350 360 GTPPVLGMVP LGEMVELVAD VGLPALTAKA TALTEFAIEV TDGLLTRHGV SVDSPRDPAQ 370 380 390 400 410 420 RGGHVTLGHP AAREVIAALW EQGVIPDFRE PDGVRLGMSP ASTSFAEVAE GLLLLDAELE RAGRG

References

[1]

"Complete genome sequence of Kytococcus sedentarius type strain (541)." Sims D., Brettin T., Detter J.C., Han C., Lapidus A., Copeland A., Glavina Del Rio T., Nolan M., Chen F., Lucas S., Tice H., Cheng J.F., Bruce D., Goodwin L., Pitluck S., Ovchinnikova G., Pati A., Ivanova N. , Mavrommatis K., Chen A., Palaniappan K., D'haeseleer P., Chain P., Bristow J., Eisen J.A., Markowitz V., Hugenholtz P., Schneider S., Goker M., Pukall R., Kyrpides N.C., Klenk H.P. Stand. Genomic Sci. 1:12-20(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 14392 / DSM 20547 / CCM 314 / 541.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001686 Genomic DNA. Translation: ACV05303.1.
RefSeq	YP_003148068.1. NC_013169.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	478801.Ksed_02180.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACV05303; ACV05303; Ksed_02180.
GeneID	8371730.
KEGG	kse:Ksed_02180.
PATRIC	22190139. VBIKytSed14067_0204.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG3844.
HOGENOM	HOG000242437.
KO	K01556.
OMA	WGGRLIR.
ProtClustDB	CLSK956672.
Enzyme and pathway databases
BioCyc	KSED478801:GI4L-217-MONOMER.
UniPathway	UPA00253; UER00329. UPA00334; UER00455.
Family and domain databases
Gene3D	3.40.640.10. 1 hit. 3.90.1150.10. 1 hit.
InterPro	IPR000192. Aminotrans_V/Cys_dSase. IPR010111. Kynureninase. IPR015424. PyrdxlP-dep_Trfase. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR015422. PyrdxlP-dep_Trfase_major_sub2. [Graphical view]
PANTHER	PTHR14084. PTHR14084. 1 hit.
Pfam	PF00266. Aminotran_5. 1 hit. [Graphical view]
PIRSF	PIRSF038800. KYNU. 1 hit.
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
ProtoNet	Search...

Entry information

Entry name

C7NJH3_KYTSD

Accession

Primary (citable) accession number: C7NJH3

Entry history

Integrated into UniProtKB/TrEMBL:	October 13, 2009
Last sequence update:	October 13, 2009
Last modified:	May 1, 2013
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)