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Protein

Kynureninase

Gene

Ksed_02180

Organism
Kytococcus sedentarius (strain ATCC 14392 / DSM 20547 / CCM 314 / 541) (Micrococcus sedentarius)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.UniRule annotation

Catalytic activityi

L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine.UniRule annotation
L-kynurenine + H2O = anthranilate + L-alanine.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi

GO - Molecular functioni

  1. kynureninase activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. NAD biosynthetic process Source: UniProtKB-UniPathway
  2. tryptophan catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotation

Keywords - Biological processi

Pyridine nucleotide biosynthesisUniRule annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Enzyme and pathway databases

BioCyciKSED478801:GI4L-217-MONOMER.
UniPathwayiUPA00253; UER00329.
UPA00334; UER00455.

Names & Taxonomyi

Protein namesi
Recommended name:
KynureninaseUniRule annotation (EC:3.7.1.3UniRule annotation)
Gene namesi
Ordered Locus Names:Ksed_02180Imported
OrganismiKytococcus sedentarius (strain ATCC 14392 / DSM 20547 / CCM 314 / 541) (Micrococcus sedentarius)Imported
Taxonomic identifieri478801 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeDermacoccaceaeKytococcus
ProteomesiUP000006666 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
Complete GO annotation...

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi478801.Ksed_02180.

Family & Domainsi

Sequence similaritiesi

Belongs to the kynureninase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG3844.
HOGENOMiHOG000242437.
KOiK01556.
OMAiQPIQGWM.
OrthoDBiEOG6N67XP.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR000192. Aminotrans_V_dom.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR14084. PTHR14084. 1 hit.
PfamiPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFiPIRSF038800. KYNU. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

C7NJH3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSLNTPDAV RARAAELDAA DELAHLRERF VPMDACGTVG GAVLSYLDGN
60 70 80 90 100
SLGRPLKSAA EALDRIVSEA WGTRLIRSWD EQWMELPLRL GDRLGEVALG
110 120 130 140 150
AAPGQVVVAD STTVMLYKLL RAGLAAAQAA DPARREIVVD TGNFPTDRYV
160 170 180 190 200
AEGIAAECDA ELVWIEADAG TGVTTEQVRD AVGSATAAVV LSHVAYRSAY
210 220 230 240 250
VADLPAITQV VHEAGGLVLW DLCHSAGVVP VDLDEHEVDL AVGCSYKYLN
260 270 280 290 300
GGPGAPAFGY VAARHQERMT QPIQGWMGHA EPFVMGPGYQ PSPGMRRFIS
310 320 330 340 350
GTPPVLGMVP LGEMVELVAD VGLPALTAKA TALTEFAIEV TDGLLTRHGV
360 370 380 390 400
SVDSPRDPAQ RGGHVTLGHP AAREVIAALW EQGVIPDFRE PDGVRLGMSP
410 420
ASTSFAEVAE GLLLLDAELE RAGRG
Length:425
Mass (Da):44,834
Last modified:October 13, 2009 - v1
Checksum:i790BCC150CBAE80E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001686 Genomic DNA. Translation: ACV05303.1.
RefSeqiYP_003148068.1. NC_013169.1.

Genome annotation databases

EnsemblBacteriaiACV05303; ACV05303; Ksed_02180.
KEGGikse:Ksed_02180.
PATRICi22190139. VBIKytSed14067_0204.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001686 Genomic DNA. Translation: ACV05303.1.
RefSeqiYP_003148068.1. NC_013169.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi478801.Ksed_02180.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACV05303; ACV05303; Ksed_02180.
KEGGikse:Ksed_02180.
PATRICi22190139. VBIKytSed14067_0204.

Phylogenomic databases

eggNOGiCOG3844.
HOGENOMiHOG000242437.
KOiK01556.
OMAiQPIQGWM.
OrthoDBiEOG6N67XP.

Enzyme and pathway databases

UniPathwayiUPA00253; UER00329.
UPA00334; UER00455.
BioCyciKSED478801:GI4L-217-MONOMER.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR000192. Aminotrans_V_dom.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR14084. PTHR14084. 1 hit.
PfamiPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFiPIRSF038800. KYNU. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 14392 / DSM 20547 / CCM 314 / 541Imported.

Entry informationi

Entry nameiC7NJH3_KYTSD
AccessioniPrimary (citable) accession number: C7NJH3
Entry historyi
Integrated into UniProtKB/TrEMBL: October 13, 2009
Last sequence update: October 13, 2009
Last modified: April 29, 2015
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.