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C7NJH3 (C7NJH3_KYTSD) Unreviewed, UniProtKB/TrEMBL

Last modified November 13, 2013. Version 27. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length425 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively By similarity. PIRNR PIRNR038800

Catalytic activity

L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine. PIRNR PIRNR038800

L-kynurenine + H2O = anthranilate + L-alanine. PIRNR PIRNR038800

Cofactor

Pyridoxal phosphate By similarity. PIRNR PIRNR038800

Pathway

Amino-acid degradation; L-kynurenine degradation; L-alanine and anthranilate from L-kynurenine: step 1/1. PIRNR PIRNR038800

Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 2/3. PIRNR PIRNR038800

Subunit structure

Homodimer By similarity. PIRNR PIRNR038800

Sequence similarities

Belongs to the kynureninase family. PIRNR PIRNR038800

Sequences

Sequence LengthMass (Da)Tools
C7NJH3 [UniParc].

Last modified October 13, 2009. Version 1.
Checksum: 790BCC150CBAE80E

FASTA42544,834
        10         20         30         40         50         60 
MTSLNTPDAV RARAAELDAA DELAHLRERF VPMDACGTVG GAVLSYLDGN SLGRPLKSAA 

        70         80         90        100        110        120 
EALDRIVSEA WGTRLIRSWD EQWMELPLRL GDRLGEVALG AAPGQVVVAD STTVMLYKLL 

       130        140        150        160        170        180 
RAGLAAAQAA DPARREIVVD TGNFPTDRYV AEGIAAECDA ELVWIEADAG TGVTTEQVRD 

       190        200        210        220        230        240 
AVGSATAAVV LSHVAYRSAY VADLPAITQV VHEAGGLVLW DLCHSAGVVP VDLDEHEVDL 

       250        260        270        280        290        300 
AVGCSYKYLN GGPGAPAFGY VAARHQERMT QPIQGWMGHA EPFVMGPGYQ PSPGMRRFIS 

       310        320        330        340        350        360 
GTPPVLGMVP LGEMVELVAD VGLPALTAKA TALTEFAIEV TDGLLTRHGV SVDSPRDPAQ 

       370        380        390        400        410        420 
RGGHVTLGHP AAREVIAALW EQGVIPDFRE PDGVRLGMSP ASTSFAEVAE GLLLLDAELE 


RAGRG 

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001686 Genomic DNA. Translation: ACV05303.1.
RefSeqYP_003148068.1. NC_013169.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING478801.Ksed_02180.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACV05303; ACV05303; Ksed_02180.
GeneID8371730.
KEGGkse:Ksed_02180.
PATRIC22190139. VBIKytSed14067_0204.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG3844.
HOGENOMHOG000242437.
KOK01556.
OMAWGGRLIR.
OrthoDBEOG6N67XP.
ProtClustDBCLSK956672.

Enzyme and pathway databases

BioCycKSED478801:GI4L-217-MONOMER.
UniPathwayUPA00253; UER00329.
UPA00334; UER00455.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProIPR000192. Aminotrans_V/Cys_dSase.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERPTHR14084. PTHR14084. 1 hit.
PfamPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFPIRSF038800. KYNU. 1 hit.
SUPFAMSSF53383. SSF53383. 1 hit.
ProtoNetSearch...

Entry information

Entry nameC7NJH3_KYTSD
AccessionPrimary (citable) accession number: C7NJH3
Entry history
Integrated into UniProtKB/TrEMBL: October 13, 2009
Last sequence update: October 13, 2009
Last modified: November 13, 2013
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)