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Protein

Methionyl-tRNA formyltransferase

Gene

fmt

Organism
Kytococcus sedentarius (strain ATCC 14392 / DSM 20547 / CCM 314 / 541) (Micrococcus sedentarius)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by: (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP.UniRule annotationSAAS annotation

Catalytic activityi

10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = tetrahydrofolate + N-formylmethionyl-tRNA(fMet).UniRule annotationSAAS annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

TransferaseUniRule annotationSAAS annotationImported

Keywords - Biological processi

Protein biosynthesisUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciKSED478801:GI4L-1272-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Methionyl-tRNA formyltransferaseUniRule annotationSAAS annotation (EC:2.1.2.9UniRule annotationSAAS annotation)
Gene namesi
Name:fmtUniRule annotation
Ordered Locus Names:Ksed_12770Imported
OrganismiKytococcus sedentarius (strain ATCC 14392 / DSM 20547 / CCM 314 / 541) (Micrococcus sedentarius)Imported
Taxonomic identifieri478801 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicrococcalesDermacoccaceaeKytococcus
Proteomesi
  • UP000006666 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi478801.Ksed_12770.

Structurei

3D structure databases

ProteinModelPortaliC7NHF2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini18 – 187170Formyl_trans_NInterPro annotationAdd
BLAST
Domaini214 – 326113Formyl_trans_CInterPro annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni120 – 1234Tetrahydrofolate (THF) bindingUniRule annotation

Sequence similaritiesi

Belongs to the Fmt family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105CAE. Bacteria.
COG0223. LUCA.
HOGENOMiHOG000261177.
KOiK00604.
OMAiNCITTFR.
OrthoDBiPOG091H01YM.

Family and domain databases

Gene3Di3.10.25.10. 1 hit.
3.40.50.170. 1 hit.
HAMAPiMF_00182. Formyl_trans. 1 hit.
InterProiIPR005794. Fmt.
IPR005793. Formyl_trans_C.
IPR002376. Formyl_transf_N.
IPR011034. Formyl_transferase_C-like.
[Graphical view]
PfamiPF02911. Formyl_trans_C. 1 hit.
PF00551. Formyl_trans_N. 1 hit.
[Graphical view]
SUPFAMiSSF50486. SSF50486. 1 hit.
SSF53328. SSF53328. 1 hit.
TIGRFAMsiTIGR00460. fmt. 1 hit.

Sequencei

Sequence statusi: Complete.

C7NHF2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLVRIVFAG TPEAALPSLE HLLDSARTAD GRDRHEVVGV LTRPDARVGR
60 70 80 90 100
GRKLRPSPVK ARALEHGLPV IESDRPWEDE PLASLRELAP DVGAIVAYGA
110 120 130 140 150
LLPTSVLELP THGWVNLHFS LLPAWRGAAP AQRALMAGDD LTGATTFVLT
160 170 180 190 200
EGMDTGPVLG TLTEAIRPTD TAGDLLERLS EAGAPLLTDS LHGLVSGALA
210 220 230 240 250
PVPQPADGVS RAPKLTVDEV RLDFTQPAFA VVRRVAGASP APGAWTTFRG
260 270 280 290 300
DRLKVLQAAQ VAGAPSSTGA GTAGPDDPST PHLPPGRLLL HDGQVLVGTA
310 320 330
THPVRLQRVQ PPGKQAMEAE AWARGARFDD QEALGG
Length:336
Mass (Da):35,194
Last modified:October 13, 2009 - v1
Checksum:iC504F90096DD9BC3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001686 Genomic DNA. Translation: ACV06309.1.

Genome annotation databases

EnsemblBacteriaiACV06309; ACV06309; Ksed_12770.
KEGGikse:Ksed_12770.
PATRICi22192211. VBIKytSed14067_1214.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001686 Genomic DNA. Translation: ACV06309.1.

3D structure databases

ProteinModelPortaliC7NHF2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi478801.Ksed_12770.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACV06309; ACV06309; Ksed_12770.
KEGGikse:Ksed_12770.
PATRICi22192211. VBIKytSed14067_1214.

Phylogenomic databases

eggNOGiENOG4105CAE. Bacteria.
COG0223. LUCA.
HOGENOMiHOG000261177.
KOiK00604.
OMAiNCITTFR.
OrthoDBiPOG091H01YM.

Enzyme and pathway databases

BioCyciKSED478801:GI4L-1272-MONOMER.

Family and domain databases

Gene3Di3.10.25.10. 1 hit.
3.40.50.170. 1 hit.
HAMAPiMF_00182. Formyl_trans. 1 hit.
InterProiIPR005794. Fmt.
IPR005793. Formyl_trans_C.
IPR002376. Formyl_transf_N.
IPR011034. Formyl_transferase_C-like.
[Graphical view]
PfamiPF02911. Formyl_trans_C. 1 hit.
PF00551. Formyl_trans_N. 1 hit.
[Graphical view]
SUPFAMiSSF50486. SSF50486. 1 hit.
SSF53328. SSF53328. 1 hit.
TIGRFAMsiTIGR00460. fmt. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiC7NHF2_KYTSD
AccessioniPrimary (citable) accession number: C7NHF2
Entry historyi
Integrated into UniProtKB/TrEMBL: October 13, 2009
Last sequence update: October 13, 2009
Last modified: September 7, 2016
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.