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C7NHF2

- C7NHF2_KYTSD

UniProt

C7NHF2 - C7NHF2_KYTSD

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Protein
Methionyl-tRNA formyltransferase
Gene
fmt, Ksed_12770
Organism
Kytococcus sedentarius (strain ATCC 14392 / DSM 20547 / CCM 314 / 541) (Micrococcus sedentarius)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by: (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP By similarity.UniRule annotationSAAS annotations

Catalytic activityi

10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = tetrahydrofolate + N-formylmethionyl-tRNA(fMet).UniRule annotationSAAS annotations

GO - Molecular functioni

  1. methionyl-tRNA formyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

TransferaseUniRule annotationSAAS annotationsImported

Keywords - Biological processi

Protein biosynthesisUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciKSED478801:GI4L-1272-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Methionyl-tRNA formyltransferaseUniRule annotation (EC:2.1.2.9UniRule annotation)
Gene namesi
Name:fmtUniRule annotation
Ordered Locus Names:Ksed_12770Imported
OrganismiKytococcus sedentarius (strain ATCC 14392 / DSM 20547 / CCM 314 / 541) (Micrococcus sedentarius)Imported
Taxonomic identifieri478801 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeDermacoccaceaeKytococcus
ProteomesiUP000006666: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi478801.Ksed_12770.

Structurei

3D structure databases

ProteinModelPortaliC7NHF2.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni120 – 1234Tetrahydrofolate (THF) binding By similarityUniRule annotation

Sequence similaritiesi

Belongs to the Fmt family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0223.
HOGENOMiHOG000261177.
KOiK00604.
OMAiRIKLGPV.
OrthoDBiEOG6B09WV.

Family and domain databases

Gene3Di3.10.25.10. 1 hit.
3.40.50.170. 1 hit.
HAMAPiMF_00182. Formyl_trans.
InterProiIPR005794. Fmt.
IPR005793. Formyl_trans_C.
IPR002376. Formyl_transf_N.
IPR011034. Formyl_transferase_C-like.
IPR015518. Met_tRNA_Form_TA-like.
[Graphical view]
PANTHERiPTHR11138. PTHR11138. 1 hit.
PfamiPF02911. Formyl_trans_C. 1 hit.
PF00551. Formyl_trans_N. 1 hit.
[Graphical view]
SUPFAMiSSF50486. SSF50486. 1 hit.
SSF53328. SSF53328. 1 hit.
TIGRFAMsiTIGR00460. fmt. 1 hit.

Sequencei

Sequence statusi: Complete.

C7NHF2-1 [UniParc]FASTAAdd to Basket

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MPLVRIVFAG TPEAALPSLE HLLDSARTAD GRDRHEVVGV LTRPDARVGR    50
GRKLRPSPVK ARALEHGLPV IESDRPWEDE PLASLRELAP DVGAIVAYGA 100
LLPTSVLELP THGWVNLHFS LLPAWRGAAP AQRALMAGDD LTGATTFVLT 150
EGMDTGPVLG TLTEAIRPTD TAGDLLERLS EAGAPLLTDS LHGLVSGALA 200
PVPQPADGVS RAPKLTVDEV RLDFTQPAFA VVRRVAGASP APGAWTTFRG 250
DRLKVLQAAQ VAGAPSSTGA GTAGPDDPST PHLPPGRLLL HDGQVLVGTA 300
THPVRLQRVQ PPGKQAMEAE AWARGARFDD QEALGG 336
Length:336
Mass (Da):35,194
Last modified:October 13, 2009 - v1
Checksum:iC504F90096DD9BC3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001686 Genomic DNA. Translation: ACV06309.1.
RefSeqiWP_015779254.1. NC_013169.1.
YP_003149074.1. NC_013169.1.

Genome annotation databases

EnsemblBacteriaiACV06309; ACV06309; Ksed_12770.
GeneIDi8372785.
KEGGikse:Ksed_12770.
PATRICi22192211. VBIKytSed14067_1214.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001686 Genomic DNA. Translation: ACV06309.1 .
RefSeqi WP_015779254.1. NC_013169.1.
YP_003149074.1. NC_013169.1.

3D structure databases

ProteinModelPortali C7NHF2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 478801.Ksed_12770.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACV06309 ; ACV06309 ; Ksed_12770 .
GeneIDi 8372785.
KEGGi kse:Ksed_12770.
PATRICi 22192211. VBIKytSed14067_1214.

Phylogenomic databases

eggNOGi COG0223.
HOGENOMi HOG000261177.
KOi K00604.
OMAi RIKLGPV.
OrthoDBi EOG6B09WV.

Enzyme and pathway databases

BioCyci KSED478801:GI4L-1272-MONOMER.

Family and domain databases

Gene3Di 3.10.25.10. 1 hit.
3.40.50.170. 1 hit.
HAMAPi MF_00182. Formyl_trans.
InterProi IPR005794. Fmt.
IPR005793. Formyl_trans_C.
IPR002376. Formyl_transf_N.
IPR011034. Formyl_transferase_C-like.
IPR015518. Met_tRNA_Form_TA-like.
[Graphical view ]
PANTHERi PTHR11138. PTHR11138. 1 hit.
Pfami PF02911. Formyl_trans_C. 1 hit.
PF00551. Formyl_trans_N. 1 hit.
[Graphical view ]
SUPFAMi SSF50486. SSF50486. 1 hit.
SSF53328. SSF53328. 1 hit.
TIGRFAMsi TIGR00460. fmt. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 14392 / DSM 20547 / CCM 314 / 541.

Entry informationi

Entry nameiC7NHF2_KYTSD
AccessioniPrimary (citable) accession number: C7NHF2
Entry historyi
Integrated into UniProtKB/TrEMBL: October 13, 2009
Last sequence update: October 13, 2009
Last modified: September 3, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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