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C7NHF2

- C7NHF2_KYTSD

UniProt

C7NHF2 - C7NHF2_KYTSD

Protein

Methionyl-tRNA formyltransferase

Gene

fmt

Organism
Kytococcus sedentarius (strain ATCC 14392 / DSM 20547 / CCM 314 / 541) (Micrococcus sedentarius)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 34 (01 Oct 2014)
      Sequence version 1 (13 Oct 2009)
      Previous versions | rss
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    Functioni

    Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by: (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP.UniRule annotationSAAS annotation

    Catalytic activityi

    10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = tetrahydrofolate + N-formylmethionyl-tRNA(fMet).UniRule annotationSAAS annotation

    GO - Molecular functioni

    1. methionyl-tRNA formyltransferase activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    TransferaseUniRule annotationSAAS annotationImported

    Keywords - Biological processi

    Protein biosynthesisUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciKSED478801:GI4L-1272-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Methionyl-tRNA formyltransferaseUniRule annotation (EC:2.1.2.9UniRule annotation)
    Gene namesi
    Name:fmtUniRule annotation
    Ordered Locus Names:Ksed_12770Imported
    OrganismiKytococcus sedentarius (strain ATCC 14392 / DSM 20547 / CCM 314 / 541) (Micrococcus sedentarius)Imported
    Taxonomic identifieri478801 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeDermacoccaceaeKytococcus
    ProteomesiUP000006666: Chromosome

    Interactioni

    Protein-protein interaction databases

    STRINGi478801.Ksed_12770.

    Structurei

    3D structure databases

    ProteinModelPortaliC7NHF2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni120 – 1234Tetrahydrofolate (THF) bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the Fmt family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0223.
    HOGENOMiHOG000261177.
    KOiK00604.
    OMAiRIKLGPV.
    OrthoDBiEOG6B09WV.

    Family and domain databases

    Gene3Di3.10.25.10. 1 hit.
    3.40.50.170. 1 hit.
    HAMAPiMF_00182. Formyl_trans.
    InterProiIPR005794. Fmt.
    IPR005793. Formyl_trans_C.
    IPR002376. Formyl_transf_N.
    IPR011034. Formyl_transferase_C-like.
    IPR015518. Met_tRNA_Form_TA-like.
    [Graphical view]
    PANTHERiPTHR11138. PTHR11138. 1 hit.
    PfamiPF02911. Formyl_trans_C. 1 hit.
    PF00551. Formyl_trans_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF50486. SSF50486. 1 hit.
    SSF53328. SSF53328. 1 hit.
    TIGRFAMsiTIGR00460. fmt. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    C7NHF2-1 [UniParc]FASTAAdd to Basket

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    MPLVRIVFAG TPEAALPSLE HLLDSARTAD GRDRHEVVGV LTRPDARVGR    50
    GRKLRPSPVK ARALEHGLPV IESDRPWEDE PLASLRELAP DVGAIVAYGA 100
    LLPTSVLELP THGWVNLHFS LLPAWRGAAP AQRALMAGDD LTGATTFVLT 150
    EGMDTGPVLG TLTEAIRPTD TAGDLLERLS EAGAPLLTDS LHGLVSGALA 200
    PVPQPADGVS RAPKLTVDEV RLDFTQPAFA VVRRVAGASP APGAWTTFRG 250
    DRLKVLQAAQ VAGAPSSTGA GTAGPDDPST PHLPPGRLLL HDGQVLVGTA 300
    THPVRLQRVQ PPGKQAMEAE AWARGARFDD QEALGG 336
    Length:336
    Mass (Da):35,194
    Last modified:October 13, 2009 - v1
    Checksum:iC504F90096DD9BC3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001686 Genomic DNA. Translation: ACV06309.1.
    RefSeqiWP_015779254.1. NC_013169.1.
    YP_003149074.1. NC_013169.1.

    Genome annotation databases

    EnsemblBacteriaiACV06309; ACV06309; Ksed_12770.
    GeneIDi8372785.
    KEGGikse:Ksed_12770.
    PATRICi22192211. VBIKytSed14067_1214.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001686 Genomic DNA. Translation: ACV06309.1 .
    RefSeqi WP_015779254.1. NC_013169.1.
    YP_003149074.1. NC_013169.1.

    3D structure databases

    ProteinModelPortali C7NHF2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 478801.Ksed_12770.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACV06309 ; ACV06309 ; Ksed_12770 .
    GeneIDi 8372785.
    KEGGi kse:Ksed_12770.
    PATRICi 22192211. VBIKytSed14067_1214.

    Phylogenomic databases

    eggNOGi COG0223.
    HOGENOMi HOG000261177.
    KOi K00604.
    OMAi RIKLGPV.
    OrthoDBi EOG6B09WV.

    Enzyme and pathway databases

    BioCyci KSED478801:GI4L-1272-MONOMER.

    Family and domain databases

    Gene3Di 3.10.25.10. 1 hit.
    3.40.50.170. 1 hit.
    HAMAPi MF_00182. Formyl_trans.
    InterProi IPR005794. Fmt.
    IPR005793. Formyl_trans_C.
    IPR002376. Formyl_transf_N.
    IPR011034. Formyl_transferase_C-like.
    IPR015518. Met_tRNA_Form_TA-like.
    [Graphical view ]
    PANTHERi PTHR11138. PTHR11138. 1 hit.
    Pfami PF02911. Formyl_trans_C. 1 hit.
    PF00551. Formyl_trans_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50486. SSF50486. 1 hit.
    SSF53328. SSF53328. 1 hit.
    TIGRFAMsi TIGR00460. fmt. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 14392 / DSM 20547 / CCM 314 / 541Imported.

    Entry informationi

    Entry nameiC7NHF2_KYTSD
    AccessioniPrimary (citable) accession number: C7NHF2
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 13, 2009
    Last sequence update: October 13, 2009
    Last modified: October 1, 2014
    This is version 34 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3