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C7NF16

- C7NF16_KYTSD

UniProt

C7NF16 - C7NF16_KYTSD

Protein

Malate dehydrogenase

Gene

mdh

Organism
Kytococcus sedentarius (strain ATCC 14392 / DSM 20547 / CCM 314 / 541) (Micrococcus sedentarius)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 38 (01 Oct 2014)
      Sequence version 1 (13 Oct 2009)
      Previous versions | rss
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    Functioni

    Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

    Catalytic activityi

    (S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotationSAAS annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei104 – 1041SubstrateUniRule annotation
    Binding sitei110 – 1101SubstrateUniRule annotation
    Binding sitei117 – 1171NADUniRule annotation
    Binding sitei124 – 1241NADUniRule annotation
    Binding sitei143 – 1431SubstrateUniRule annotation
    Binding sitei174 – 1741SubstrateUniRule annotation
    Active sitei199 – 1991Proton acceptorUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi23 – 297NADUniRule annotation
    Nucleotide bindingi141 – 1433NADUniRule annotation

    GO - Molecular functioni

    1. L-malate dehydrogenase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. cellular carbohydrate metabolic process Source: InterPro
    2. malate metabolic process Source: InterPro
    3. tricarboxylic acid cycle Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotationImported

    Keywords - Biological processi

    Tricarboxylic acid cycleUniRule annotationSAAS annotation

    Keywords - Ligandi

    NADUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciKSED478801:GI4L-780-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
    Gene namesi
    Name:mdhUniRule annotation
    Ordered Locus Names:Ksed_07840Imported
    OrganismiKytococcus sedentarius (strain ATCC 14392 / DSM 20547 / CCM 314 / 541) (Micrococcus sedentarius)Imported
    Taxonomic identifieri478801 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeDermacoccaceaeKytococcus
    ProteomesiUP000006666: Chromosome

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotationSAAS annotation

    Protein-protein interaction databases

    STRINGi478801.Ksed_07840.

    Structurei

    3D structure databases

    ProteinModelPortaliC7NF16.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LDH/MDH superfamily. MDH type 2 family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0039.
    HOGENOMiHOG000220953.
    KOiK00024.
    OMAiAFSQECI.
    OrthoDBiEOG6PP9Q2.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    HAMAPiMF_01517. Malate_dehydrog_2.
    InterProiIPR001557. L-lactate/malate_DH.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR001252. Malate_DH_AS.
    IPR010945. Malate_DH_type2.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR23382. PTHR23382. 1 hit.
    PfamiPF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
    SUPFAMiSSF56327. SSF56327. 1 hit.
    TIGRFAMsiTIGR01759. MalateDH-SF1. 1 hit.
    PROSITEiPS00068. MDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C7NF16-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAQIHVITQE VLVTQPVKVA VTGAAGQIGY SLLFRIASGE LLGPDTPVQL    50
    RLLEITPALE ALEGVVMELD DSAFPLLSGV EIGDDANTIF DGANVALLVG 100
    ARPRGKGMER SDLLEANGQI FTGQGKALND NAADDIRVTV TGNPANTNAL 150
    ITMNNAPDIP AERFSALTRL DHNRALAQLA KKAGVSINDI QRMTIWGNHS 200
    ATQYPDIFHA TINGENAAEV VDDQQWLEND FIPTVSQRGA AIIEARGSSS 250
    AASAASATID HTRTWLSGTA EGNWTSMAVR SDGSYGVPEG LISSFPVTTK 300
    DGEYEIVQGL EINEFSQGKI DATVAELSEE RDTVRAKGLI EG 342
    Length:342
    Mass (Da):36,294
    Last modified:October 13, 2009 - v1
    Checksum:i05F90D2930964E83
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001686 Genomic DNA. Translation: ACV05840.1.
    RefSeqiYP_003148605.1. NC_013169.1.

    Genome annotation databases

    EnsemblBacteriaiACV05840; ACV05840; Ksed_07840.
    GeneIDi8372293.
    KEGGikse:Ksed_07840.
    PATRICi22191223. VBIKytSed14067_0735.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001686 Genomic DNA. Translation: ACV05840.1 .
    RefSeqi YP_003148605.1. NC_013169.1.

    3D structure databases

    ProteinModelPortali C7NF16.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 478801.Ksed_07840.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACV05840 ; ACV05840 ; Ksed_07840 .
    GeneIDi 8372293.
    KEGGi kse:Ksed_07840.
    PATRICi 22191223. VBIKytSed14067_0735.

    Phylogenomic databases

    eggNOGi COG0039.
    HOGENOMi HOG000220953.
    KOi K00024.
    OMAi AFSQECI.
    OrthoDBi EOG6PP9Q2.

    Enzyme and pathway databases

    BioCyci KSED478801:GI4L-780-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    HAMAPi MF_01517. Malate_dehydrog_2.
    InterProi IPR001557. L-lactate/malate_DH.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR001252. Malate_DH_AS.
    IPR010945. Malate_DH_type2.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR23382. PTHR23382. 1 hit.
    Pfami PF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
    SUPFAMi SSF56327. SSF56327. 1 hit.
    TIGRFAMsi TIGR01759. MalateDH-SF1. 1 hit.
    PROSITEi PS00068. MDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 14392 / DSM 20547 / CCM 314 / 541Imported.

    Entry informationi

    Entry nameiC7NF16_KYTSD
    AccessioniPrimary (citable) accession number: C7NF16
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 13, 2009
    Last sequence update: October 13, 2009
    Last modified: October 1, 2014
    This is version 38 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3