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Protein

Malate dehydrogenase

Gene

mdh

Organism
Kytococcus sedentarius (strain ATCC 14392 / DSM 20547 / CCM 314 / 541) (Micrococcus sedentarius)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotationSAAS annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei104SubstrateUniRule annotation1
Binding sitei110SubstrateUniRule annotation1
Binding sitei117NADUniRule annotation1
Binding sitei124NADUniRule annotation1
Binding sitei143SubstrateUniRule annotation1
Binding sitei174SubstrateUniRule annotation1
Active sitei199Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi23 – 29NADUniRule annotation7
Nucleotide bindingi141 – 143NADUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationImported
Biological processTricarboxylic acid cycleUniRule annotation
LigandNADUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotationSAAS annotation (EC:1.1.1.37UniRule annotationSAAS annotation)
Gene namesi
Name:mdhUniRule annotation
Ordered Locus Names:Ksed_07840Imported
OrganismiKytococcus sedentarius (strain ATCC 14392 / DSM 20547 / CCM 314 / 541) (Micrococcus sedentarius)Imported
Taxonomic identifieri478801 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicrococcalesDermacoccaceaeKytococcus
Proteomesi
  • UP000006666 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi478801.Ksed_07840

Structurei

3D structure databases

ProteinModelPortaliC7NF16
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini17 – 161Ldh_1_NInterPro annotationAdd BLAST145
Domaini168 – 334Ldh_1_CInterPro annotationAdd BLAST167

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 2 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D9Z Bacteria
COG0039 LUCA
HOGENOMiHOG000220953
KOiK00024
OMAiRPRTKGM
OrthoDBiPOG091H03R4

Family and domain databases

Gene3Di3.90.110.10, 1 hit
HAMAPiMF_01517 Malate_dehydrog_2, 1 hit
InterProiView protein in InterPro
IPR001557 L-lactate/malate_DH
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR001252 Malate_DH_AS
IPR010945 Malate_DH_type2
IPR036291 NAD(P)-bd_dom_sf
PANTHERiPTHR23382 PTHR23382, 1 hit
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
PIRSFiPIRSF000102 Lac_mal_DH, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
SSF56327 SSF56327, 1 hit
TIGRFAMsiTIGR01759 MalateDH-SF1, 1 hit
PROSITEiView protein in PROSITE
PS00068 MDH, 1 hit

Sequencei

Sequence statusi: Complete.

C7NF16-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQIHVITQE VLVTQPVKVA VTGAAGQIGY SLLFRIASGE LLGPDTPVQL
60 70 80 90 100
RLLEITPALE ALEGVVMELD DSAFPLLSGV EIGDDANTIF DGANVALLVG
110 120 130 140 150
ARPRGKGMER SDLLEANGQI FTGQGKALND NAADDIRVTV TGNPANTNAL
160 170 180 190 200
ITMNNAPDIP AERFSALTRL DHNRALAQLA KKAGVSINDI QRMTIWGNHS
210 220 230 240 250
ATQYPDIFHA TINGENAAEV VDDQQWLEND FIPTVSQRGA AIIEARGSSS
260 270 280 290 300
AASAASATID HTRTWLSGTA EGNWTSMAVR SDGSYGVPEG LISSFPVTTK
310 320 330 340
DGEYEIVQGL EINEFSQGKI DATVAELSEE RDTVRAKGLI EG
Length:342
Mass (Da):36,294
Last modified:October 13, 2009 - v1
Checksum:i05F90D2930964E83
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001686 Genomic DNA Translation: ACV05840.1

Genome annotation databases

EnsemblBacteriaiACV05840; ACV05840; Ksed_07840
KEGGikse:Ksed_07840

Similar proteinsi

Entry informationi

Entry nameiC7NF16_KYTSD
AccessioniPrimary (citable) accession number: C7NF16
Entry historyiIntegrated into UniProtKB/TrEMBL: October 13, 2009
Last sequence update: October 13, 2009
Last modified: May 23, 2018
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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