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Protein

Malate dehydrogenase

Gene

mdh

Organism
Kytococcus sedentarius (strain ATCC 14392 / DSM 20547 / CCM 314 / 541) (Micrococcus sedentarius)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei104 – 1041SubstrateUniRule annotation
Binding sitei110 – 1101SubstrateUniRule annotation
Binding sitei117 – 1171NADUniRule annotation
Binding sitei124 – 1241NADUniRule annotation
Binding sitei143 – 1431SubstrateUniRule annotation
Binding sitei174 – 1741SubstrateUniRule annotation
Active sitei199 – 1991Proton acceptorUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi23 – 297NADUniRule annotation
Nucleotide bindingi141 – 1433NADUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

NADUniRule annotation

Enzyme and pathway databases

BioCyciKSED478801:GI4L-780-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
Gene namesi
Name:mdhUniRule annotation
Ordered Locus Names:Ksed_07840Imported
OrganismiKytococcus sedentarius (strain ATCC 14392 / DSM 20547 / CCM 314 / 541) (Micrococcus sedentarius)Imported
Taxonomic identifieri478801 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicrococcalesDermacoccaceaeKytococcus
ProteomesiUP000006666 Componenti: Chromosome

Interactioni

Subunit structurei

Homodimer.UniRule annotationSAAS annotation

Protein-protein interaction databases

STRINGi478801.Ksed_07840.

Structurei

3D structure databases

ProteinModelPortaliC7NF16.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 2 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0039.
HOGENOMiHOG000220953.
KOiK00024.
OMAiWNNDVFL.
OrthoDBiEOG6PP9Q2.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_01517. Malate_dehydrog_2.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR001252. Malate_DH_AS.
IPR010945. Malate_DH_type2.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23382. PTHR23382. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMiSSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01759. MalateDH-SF1. 1 hit.
PROSITEiPS00068. MDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C7NF16-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQIHVITQE VLVTQPVKVA VTGAAGQIGY SLLFRIASGE LLGPDTPVQL
60 70 80 90 100
RLLEITPALE ALEGVVMELD DSAFPLLSGV EIGDDANTIF DGANVALLVG
110 120 130 140 150
ARPRGKGMER SDLLEANGQI FTGQGKALND NAADDIRVTV TGNPANTNAL
160 170 180 190 200
ITMNNAPDIP AERFSALTRL DHNRALAQLA KKAGVSINDI QRMTIWGNHS
210 220 230 240 250
ATQYPDIFHA TINGENAAEV VDDQQWLEND FIPTVSQRGA AIIEARGSSS
260 270 280 290 300
AASAASATID HTRTWLSGTA EGNWTSMAVR SDGSYGVPEG LISSFPVTTK
310 320 330 340
DGEYEIVQGL EINEFSQGKI DATVAELSEE RDTVRAKGLI EG
Length:342
Mass (Da):36,294
Last modified:October 13, 2009 - v1
Checksum:i05F90D2930964E83
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001686 Genomic DNA. Translation: ACV05840.1.

Genome annotation databases

EnsemblBacteriaiACV05840; ACV05840; Ksed_07840.
KEGGikse:Ksed_07840.
PATRICi22191223. VBIKytSed14067_0735.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001686 Genomic DNA. Translation: ACV05840.1.

3D structure databases

ProteinModelPortaliC7NF16.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi478801.Ksed_07840.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACV05840; ACV05840; Ksed_07840.
KEGGikse:Ksed_07840.
PATRICi22191223. VBIKytSed14067_0735.

Phylogenomic databases

eggNOGiCOG0039.
HOGENOMiHOG000220953.
KOiK00024.
OMAiWNNDVFL.
OrthoDBiEOG6PP9Q2.

Enzyme and pathway databases

BioCyciKSED478801:GI4L-780-MONOMER.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_01517. Malate_dehydrog_2.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR001252. Malate_DH_AS.
IPR010945. Malate_DH_type2.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23382. PTHR23382. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMiSSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01759. MalateDH-SF1. 1 hit.
PROSITEiPS00068. MDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 14392 / DSM 20547 / CCM 314 / 541Imported.

Entry informationi

Entry nameiC7NF16_KYTSD
AccessioniPrimary (citable) accession number: C7NF16
Entry historyi
Integrated into UniProtKB/TrEMBL: October 13, 2009
Last sequence update: October 13, 2009
Last modified: July 22, 2015
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.