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Protein

2,3-bisphosphoglycerate-dependent phosphoglycerate mutase

Gene

gpmA

Organism
Slackia heliotrinireducens (strain ATCC 29202 / DSM 20476 / NCTC 11029 / RHS 1) (Peptococcus heliotrinreducens)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.UniRule annotation

Catalytic activityi

2-phospho-D-glycerate = 3-phospho-D-glycerate.UniRule annotationSAAS annotation

Pathwayi: glycolysis

This protein is involved in step 3 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Phosphoglycerate kinase (pgk)
  3. 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (gpmA)
  4. Enolase (eno)
  5. no protein annotated in this organism
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei13Tele-phosphohistidine intermediateUniRule annotation1
Binding sitei64SubstrateUniRule annotation1
Active sitei91Proton donor/acceptorUniRule annotation1
Binding sitei102SubstrateUniRule annotation1
Sitei186Transition state stabilizerUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotationImported

Keywords - Biological processi

GluconeogenesisUniRule annotation, GlycolysisUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00109; UER00186.

Names & Taxonomyi

Protein namesi
Recommended name:
2,3-bisphosphoglycerate-dependent phosphoglycerate mutaseUniRule annotation (EC:5.4.2.11UniRule annotation)
Short name:
BPG-dependent PGAMUniRule annotation
Short name:
PGAMUniRule annotation
Short name:
PhosphoglyceromutaseUniRule annotation
Short name:
dPGMUniRule annotation
Gene namesi
Name:gpmAUniRule annotation
Ordered Locus Names:Shel_06510Imported
OrganismiSlackia heliotrinireducens (strain ATCC 29202 / DSM 20476 / NCTC 11029 / RHS 1) (Peptococcus heliotrinreducens)Imported
Taxonomic identifieri471855 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCoriobacteriiaEggerthellalesEggerthellaceaeSlackia
Proteomesi
  • UP000002026 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi471855.Shel_06510.

Structurei

3D structure databases

ProteinModelPortaliC7N3W9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni12 – 19Substrate bindingUniRule annotation8
Regioni25 – 26Substrate bindingUniRule annotation2
Regioni91 – 94Substrate bindingUniRule annotation4
Regioni118 – 119Substrate bindingUniRule annotation2
Regioni187 – 188Substrate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4107RPC. Bacteria.
COG0588. LUCA.
HOGENOMiHOG000221682.
KOiK01834.
OMAiVKNQGKK.
OrthoDBiPOG091H03E2.

Family and domain databases

CDDicd07067. HP_PGM_like. 1 hit.
Gene3Di3.40.50.1240. 1 hit.
HAMAPiMF_01039. PGAM_GpmA. 1 hit.
InterProiIPR013078. His_Pase_superF_clade-1.
IPR029033. His_PPase_superfam.
IPR001345. PG/BPGM_mutase_AS.
IPR005952. Phosphogly_mut1.
[Graphical view]
PANTHERiPTHR11931. PTHR11931. 1 hit.
PfamiPF00300. His_Phos_1. 1 hit.
[Graphical view]
SMARTiSM00855. PGAM. 1 hit.
[Graphical view]
SUPFAMiSSF53254. SSF53254. 1 hit.
TIGRFAMsiTIGR01258. pgm_1. 1 hit.
PROSITEiPS00175. PG_MUTASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C7N3W9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAENTMTLVL IRHGESEWNK LNLFTGWTDV ELTDTGRKEA AEGGRALKAD
60 70 80 90 100
GYDFDICYTS YLKRAIHTLQ IVLDNMDRHW LPVEKTWRLN ERHYGALQGL
110 120 130 140 150
NKSETAEKYG EEQVKIWRRS FDVRPPALEA GDERDAHIQP AYRDVDPADV
160 170 180 190 200
PYAECLKDTI ARAMPYFNET ILPQMRAGKR VLIAAHGNSL RALVKEFDKL
210 220 230 240 250
SDEEIIGVNI PTGVPLVYTF DQDMNVLDKH YVGDPATIDA KINKVANQGK

KAQ
Length:253
Mass (Da):28,746
Last modified:October 13, 2009 - v1
Checksum:i6947F7DC490538CF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001684 Genomic DNA. Translation: ACV21710.1.
RefSeqiWP_012797815.1. NC_013165.1.

Genome annotation databases

EnsemblBacteriaiACV21710; ACV21710; Shel_06510.
KEGGishi:Shel_06510.
PATRICi23640889. VBISlaHel66389_0663.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001684 Genomic DNA. Translation: ACV21710.1.
RefSeqiWP_012797815.1. NC_013165.1.

3D structure databases

ProteinModelPortaliC7N3W9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi471855.Shel_06510.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACV21710; ACV21710; Shel_06510.
KEGGishi:Shel_06510.
PATRICi23640889. VBISlaHel66389_0663.

Phylogenomic databases

eggNOGiENOG4107RPC. Bacteria.
COG0588. LUCA.
HOGENOMiHOG000221682.
KOiK01834.
OMAiVKNQGKK.
OrthoDBiPOG091H03E2.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00186.

Family and domain databases

CDDicd07067. HP_PGM_like. 1 hit.
Gene3Di3.40.50.1240. 1 hit.
HAMAPiMF_01039. PGAM_GpmA. 1 hit.
InterProiIPR013078. His_Pase_superF_clade-1.
IPR029033. His_PPase_superfam.
IPR001345. PG/BPGM_mutase_AS.
IPR005952. Phosphogly_mut1.
[Graphical view]
PANTHERiPTHR11931. PTHR11931. 1 hit.
PfamiPF00300. His_Phos_1. 1 hit.
[Graphical view]
SMARTiSM00855. PGAM. 1 hit.
[Graphical view]
SUPFAMiSSF53254. SSF53254. 1 hit.
TIGRFAMsiTIGR01258. pgm_1. 1 hit.
PROSITEiPS00175. PG_MUTASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiC7N3W9_SLAHD
AccessioniPrimary (citable) accession number: C7N3W9
Entry historyi
Integrated into UniProtKB/TrEMBL: October 13, 2009
Last sequence update: October 13, 2009
Last modified: November 30, 2016
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.