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Protein

Ribose-phosphate pyrophosphokinase

Gene

prs

Organism
Saccharomonospora viridis (strain ATCC 15386 / DSM 43017 / JCM 3036 / NBRC 12207 / P101)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).UniRule annotation

Catalytic activityi

ATP + D-ribose 5-phosphate = AMP + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 2 Mg2+ ions per subunit.UniRule annotation

Pathwayi: 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Ribose-phosphate pyrophosphokinase (prs)
This subpathway is part of the pathway 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I), the pathway 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis and in Metabolic intermediate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi138MagnesiumUniRule annotation1
Metal bindingi178MagnesiumUniRule annotation1
Active sitei202UniRule annotation1
Binding sitei204Ribose-5-phosphateUniRule annotation1
Binding sitei230Ribose-5-phosphateUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi45 – 47ATPUniRule annotation3
Nucleotide bindingi104 – 105ATPUniRule annotation2

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotationImported, Transferase
Biological processNucleotide biosynthesisUniRule annotation
LigandATP-bindingUniRule annotation, MagnesiumUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00087; UER00172.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribose-phosphate pyrophosphokinaseUniRule annotation (EC:2.7.6.1UniRule annotation)
Short name:
RPPKUniRule annotation
Alternative name(s):
5-phospho-D-ribosyl alpha-1-diphosphateUniRule annotation
Phosphoribosyl diphosphate synthaseUniRule annotation
Phosphoribosyl pyrophosphate synthaseUniRule annotation
Short name:
P-Rib-PP synthaseUniRule annotation
Short name:
PRPP synthaseUniRule annotation
Short name:
PRPPaseUniRule annotation
Gene namesi
Name:prsUniRule annotation
Ordered Locus Names:Svir_32370Imported
OrganismiSaccharomonospora viridis (strain ATCC 15386 / DSM 43017 / JCM 3036 / NBRC 12207 / P101)Imported
Taxonomic identifieri471857 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaPseudonocardialesPseudonocardiaceaeSaccharomonospora
Proteomesi
  • UP000000841 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homohexamer.UniRule annotation

Protein-protein interaction databases

STRINGi471857.Svir_32370.

Structurei

3D structure databases

ProteinModelPortaliC7MZH9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 128Pribosyltran_NInterPro annotationAdd BLAST117

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni234 – 238Ribose-5-phosphate bindingUniRule annotation5

Sequence similaritiesi

Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C5T. Bacteria.
COG0462. LUCA.
HOGENOMiHOG000210449.
KOiK00948.
OMAiFGWARQD.
OrthoDBiPOG091H018X.

Family and domain databases

CDDicd06223. PRTases_typeI. 1 hit.
HAMAPiMF_00583_B. RibP_PPkinase_B. 1 hit.
InterProiView protein in InterPro
IPR000842. PRib_PP_synth_CS.
IPR029099. Pribosyltran_N.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
IPR005946. Rib-P_diPkinase.
PfamiView protein in Pfam
PF14572. Pribosyl_synth. 1 hit.
PF13793. Pribosyltran_N. 1 hit.
SUPFAMiSSF53271. SSF53271. 1 hit.
TIGRFAMsiTIGR01251. ribP_PPkin. 1 hit.
PROSITEiView protein in PROSITE
PS00114. PRPP_SYNTHASE. 1 hit.

Sequencei

Sequence statusi: Complete.

C7MZH9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPKSGTPKK NLMLFSGRSH VELAEEVAKH LNVTITPQTL HSFANGEIYV
60 70 80 90 100
RYQESVRGTD AFVLQSFSPP INEWIMEQLI MVDALKRASA KRITVIMPFY
110 120 130 140 150
PYSRQDKKHK GREPISARLI ADLFKTAGAD RIMTVDLHTA QIQGFFDGPV
160 170 180 190 200
DHLLAQTVLA NYINDTYGDN DITVVSPDSG RVRLAEKWAD QLGSRPIAFI
210 220 230 240 250
HKTRDPDKPN QAVANRVVGE VKGRLCVLID DMIDTGGTIT QAADALMEEG
260 270 280 290 300
AADVVIASTH GILSDPATER LSKSPVREVV VTNTLPIPEE KRIPKLTVLS
310 320
IAPLLARAIQ EVFEDGSVTS LFDGSA
Length:326
Mass (Da):35,783
Last modified:October 13, 2009 - v1
Checksum:iC1BC2B73B066B688
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001683 Genomic DNA. Translation: ACU98208.1.
RefSeqiWP_015787518.1. NC_013159.1.

Genome annotation databases

EnsemblBacteriaiACU98208; ACU98208; Svir_32370.
KEGGisvi:Svir_32370.

Similar proteinsi

Entry informationi

Entry nameiC7MZH9_SACVD
AccessioniPrimary (citable) accession number: C7MZH9
Entry historyiIntegrated into UniProtKB/TrEMBL: October 13, 2009
Last sequence update: October 13, 2009
Last modified: November 22, 2017
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported