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C7MZH9

- C7MZH9_SACVD

UniProt

C7MZH9 - C7MZH9_SACVD

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Protein

Ribose-phosphate pyrophosphokinase

Gene

prs

Organism
Saccharomonospora viridis (strain ATCC 15386 / DSM 43017 / JCM 3036 / NBRC 12207 / P101)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + D-ribose 5-phosphate = AMP + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

Cofactori

Note: Binds 1 magnesium ion per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi136 – 1361MagnesiumUniRule annotation
Metal bindingi138 – 1381MagnesiumUniRule annotation
Metal bindingi147 – 1471MagnesiumUniRule annotation
Metal bindingi151 – 1511MagnesiumUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. kinase activity Source: UniProtKB-KW
  3. magnesium ion binding Source: UniProtKB-HAMAP
  4. ribose phosphate diphosphokinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 5-phosphoribose 1-diphosphate biosynthetic process Source: UniProtKB-UniPathway
  2. nucleotide biosynthetic process Source: UniProtKB-KW
  3. ribonucleoside monophosphate biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationImported, Transferase

Keywords - Biological processi

Nucleotide biosynthesisUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, MagnesiumUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciSVIR471857:GHAV-3224-MONOMER.
UniPathwayiUPA00087; UER00172.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribose-phosphate pyrophosphokinaseUniRule annotation (EC:2.7.6.1UniRule annotation)
Short name:
RPPKUniRule annotation
Alternative name(s):
Phosphoribosyl pyrophosphate synthaseUniRule annotation
Gene namesi
Name:prsUniRule annotation
Ordered Locus Names:Svir_32370Imported
OrganismiSaccharomonospora viridis (strain ATCC 15386 / DSM 43017 / JCM 3036 / NBRC 12207 / P101)Imported
Taxonomic identifieri471857 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesPseudonocardineaePseudonocardiaceaeSaccharomonospora
ProteomesiUP000000841: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi471857.Svir_32370.

Structurei

3D structure databases

ProteinModelPortaliC7MZH9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni223 – 236145-phosphoribose 1-diphosphate bindingUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ribose-phosphate pyrophosphokinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0462.
HOGENOMiHOG000210449.
KOiK00948.
OMAiVNEHLME.
OrthoDBiEOG6Z99XQ.

Family and domain databases

Gene3Di3.40.50.2020. 2 hits.
HAMAPiMF_00583_B. RibP_PPkinase_B.
InterProiIPR000842. PRib_PP_synth_CS.
IPR029099. Pribosyltran_N.
IPR029057. PRTase-like.
IPR005946. Rib-P_diPkinase.
[Graphical view]
PfamiPF14572. Pribosyl_synth. 1 hit.
PF13793. Pribosyltran_N. 1 hit.
[Graphical view]
SUPFAMiSSF53271. SSF53271. 1 hit.
TIGRFAMsiTIGR01251. ribP_PPkin. 1 hit.
PROSITEiPS00114. PRPP_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C7MZH9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSPKSGTPKK NLMLFSGRSH VELAEEVAKH LNVTITPQTL HSFANGEIYV
60 70 80 90 100
RYQESVRGTD AFVLQSFSPP INEWIMEQLI MVDALKRASA KRITVIMPFY
110 120 130 140 150
PYSRQDKKHK GREPISARLI ADLFKTAGAD RIMTVDLHTA QIQGFFDGPV
160 170 180 190 200
DHLLAQTVLA NYINDTYGDN DITVVSPDSG RVRLAEKWAD QLGSRPIAFI
210 220 230 240 250
HKTRDPDKPN QAVANRVVGE VKGRLCVLID DMIDTGGTIT QAADALMEEG
260 270 280 290 300
AADVVIASTH GILSDPATER LSKSPVREVV VTNTLPIPEE KRIPKLTVLS
310 320
IAPLLARAIQ EVFEDGSVTS LFDGSA
Length:326
Mass (Da):35,783
Last modified:October 13, 2009 - v1
Checksum:iC1BC2B73B066B688
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001683 Genomic DNA. Translation: ACU98208.1.
RefSeqiWP_015787518.1. NC_013159.1.
YP_003135035.1. NC_013159.1.

Genome annotation databases

EnsemblBacteriaiACU98208; ACU98208; Svir_32370.
GeneIDi8388561.
KEGGisvi:Svir_32370.
PATRICi23397042. VBISacVir111818_3296.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001683 Genomic DNA. Translation: ACU98208.1 .
RefSeqi WP_015787518.1. NC_013159.1.
YP_003135035.1. NC_013159.1.

3D structure databases

ProteinModelPortali C7MZH9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 471857.Svir_32370.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACU98208 ; ACU98208 ; Svir_32370 .
GeneIDi 8388561.
KEGGi svi:Svir_32370.
PATRICi 23397042. VBISacVir111818_3296.

Phylogenomic databases

eggNOGi COG0462.
HOGENOMi HOG000210449.
KOi K00948.
OMAi VNEHLME.
OrthoDBi EOG6Z99XQ.

Enzyme and pathway databases

UniPathwayi UPA00087 ; UER00172 .
BioCyci SVIR471857:GHAV-3224-MONOMER.

Family and domain databases

Gene3Di 3.40.50.2020. 2 hits.
HAMAPi MF_00583_B. RibP_PPkinase_B.
InterProi IPR000842. PRib_PP_synth_CS.
IPR029099. Pribosyltran_N.
IPR029057. PRTase-like.
IPR005946. Rib-P_diPkinase.
[Graphical view ]
Pfami PF14572. Pribosyl_synth. 1 hit.
PF13793. Pribosyltran_N. 1 hit.
[Graphical view ]
SUPFAMi SSF53271. SSF53271. 1 hit.
TIGRFAMsi TIGR01251. ribP_PPkin. 1 hit.
PROSITEi PS00114. PRPP_SYNTHASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15386 / DSM 43017 / JCM 3036 / NBRC 12207 / P101Imported.

Entry informationi

Entry nameiC7MZH9_SACVD
AccessioniPrimary (citable) accession number: C7MZH9
Entry historyi
Integrated into UniProtKB/TrEMBL: October 13, 2009
Last sequence update: October 13, 2009
Last modified: November 26, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3