C7MZH9 (C7MZH9_SACVD) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Ribose-phosphate pyrophosphokinase HAMAP-Rule MF_00583
Short name=RPPK HAMAP-Rule MF_00583
EC=2.7.6.1 HAMAP-Rule MF_00583

Alternative name(s):
Phosphoribosyl pyrophosphate synthase HAMAP-Rule MF_00583

Gene names

Name:	prs HAMAP-Rule MF_00583
Ordered Locus Names:	Svir_32370

Organism

Saccharomonospora viridis (strain ATCC 15386 / DSM 43017 / JCM 3036 / NBRC 12207 / P101) [Complete proteome] [HAMAP] EMBL ACU98208.1

Taxonomic identifier

471857 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Actinobacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Pseudonocardineae › Pseudonocardiaceae › Saccharomonospora › Saccharomonospora viridis

Protein attributes

Sequence length	326 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + D-ribose 5-phosphate = AMP + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP-Rule MF_00583 RuleBase RU004325
Cofactor	Binds 1 magnesium ion per subunit By similarity. HAMAP-Rule MF_00583
Pathway	Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1. HAMAP-Rule MF_00583
Subcellular location	Cytoplasm By similarity HAMAP-Rule MF_00583.
Sequence similarities	Belongs to the ribose-phosphate pyrophosphokinase family. HAMAP-Rule MF_00583 RuleBase RU004324

Ontologies

Keywords
Biological process	Nucleotide biosynthesis HAMAP-Rule MF_00583 RuleBase RU004324
Cellular component	Cytoplasm HAMAP-Rule MF_00583
Ligand	ATP-binding HAMAP-Rule MF_00583 Magnesium HAMAP-Rule MF_00583 RuleBase RU004325 Metal-binding HAMAP-Rule MF_00583 RuleBase RU004325 Nucleotide-binding
Molecular function	Kinase HAMAP-Rule MF_00583 RuleBase RU004325 EMBL ACU98208.1 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	5-phosphoribose 1-diphosphate biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway nucleoside metabolic process Inferred from electronic annotation. Source: InterPro nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW ribonucleoside monophosphate biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW kinase activity Inferred from electronic annotation. Source: UniProtKB-KW magnesium ion binding Inferred from electronic annotation. Source: HAMAP ribose phosphate diphosphokinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Region	223 – 236	14	5-phosphoribose 1-diphosphate binding By similarity HAMAP-Rule MF_00583
Sites
	Metal binding	136	1	Magnesium By similarity HAMAP-Rule MF_00583
	Metal binding	138	1	Magnesium By similarity HAMAP-Rule MF_00583
	Metal binding	147	1	Magnesium By similarity HAMAP-Rule MF_00583
	Metal binding	151	1	Magnesium By similarity HAMAP-Rule MF_00583

Sequences

	Sequence		Length	Mass (Da)
	C7MZH9 [UniParc]. Last modified October 13, 2009. Version 1. Checksum: C1BC2B73B066B688	FASTA	326	35,783
	10 20 30 40 50 60 MSPKSGTPKK NLMLFSGRSH VELAEEVAKH LNVTITPQTL HSFANGEIYV RYQESVRGTD 70 80 90 100 110 120 AFVLQSFSPP INEWIMEQLI MVDALKRASA KRITVIMPFY PYSRQDKKHK GREPISARLI 130 140 150 160 170 180 ADLFKTAGAD RIMTVDLHTA QIQGFFDGPV DHLLAQTVLA NYINDTYGDN DITVVSPDSG 190 200 210 220 230 240 RVRLAEKWAD QLGSRPIAFI HKTRDPDKPN QAVANRVVGE VKGRLCVLID DMIDTGGTIT 250 260 270 280 290 300 QAADALMEEG AADVVIASTH GILSDPATER LSKSPVREVV VTNTLPIPEE KRIPKLTVLS 310 320 IAPLLARAIQ EVFEDGSVTS LFDGSA

References

[1]

"Complete genome sequence of Saccharomonospora viridis type strain (P101)." Pati A., Sikorski J., Nolan M., Lapidus A., Copeland A., Glavina del Rio T., Lucas S., Chen F., Tice H., Pitluck S., Cheng J.-F., Chertkov O., Brettin T., Han C., Detter J.C., Kuske C., Bruce D., Goodwin L. , Chain P., D'haeseleer P., Chen A., Palaniappan K., Ivanova N., Mavromatis K., Mikhailova N., Rohde M., Tindall B.J., Goeker M., Bristow J., Eisen J.A., Markowitz V., Hugenholtz P., Kyrpides N.C., Klenk H.-P. Stand. Genomic Sci. 1:141-149(2009) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 15386 / DSM 43017 / JCM 3036 / NBRC 12207 / P101.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001683 Genomic DNA. Translation: ACU98208.1.
RefSeq	YP_003135035.1. NC_013159.1.
3D structure databases
ProteinModelPortal	C7MZH9.
ModBase	Search...
Protein-protein interaction databases
STRING	471857.Svir_32370.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACU98208; ACU98208; Svir_32370.
GeneID	8388561.
KEGG	svi:Svir_32370.
PATRIC	23397042. VBISacVir111818_3296.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0462.
HOGENOM	HOG000210449.
KO	K00948.
OMA	TRISPTE.
ProtClustDB	PRK03092.
Enzyme and pathway databases
BioCyc	SVIR471857:GHAV-3224-MONOMER.
UniPathway	UPA00087; UER00172.
Family and domain databases
HAMAP	MF_00583_B. RibP_PPkinase_B.
InterPro	IPR000842. PRib_PP_synth_CS. IPR000836. PRibTrfase_dom. IPR005946. Rib-P_diPkinase. [Graphical view]
Pfam	PF00156. Pribosyltran. 1 hit. [Graphical view]
TIGRFAMs	TIGR01251. ribP_PPkin. 1 hit.
PROSITE	PS00114. PRPP_SYNTHASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

C7MZH9_SACVD

Accession

Primary (citable) accession number: C7MZH9

Entry history

Integrated into UniProtKB/TrEMBL:	October 13, 2009
Last sequence update:	October 13, 2009
Last modified:	May 29, 2013
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)