Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ribose-phosphate pyrophosphokinase

Gene

prs

Organism
Saccharomonospora viridis (strain ATCC 15386 / DSM 43017 / JCM 3036 / NBRC 12207 / P101)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in the biosynthesis of ribose 1,5-bisphosphate. Catalyzes the transfer of pyrophosphoryl group from ATP to ribose-5-phosphate to yield phosphoribosyl diphosphate (PRPP) and AMP.UniRule annotation

Catalytic activityi

ATP + D-ribose 5-phosphate = AMP + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 1 Mg2+ ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei112 – 1121Ribose-5-phosphateUniRule annotation
Metal bindingi136 – 1361MagnesiumUniRule annotation
Metal bindingi138 – 1381MagnesiumUniRule annotation
Binding sitei138 – 1381ATPUniRule annotation
Binding sitei143 – 1431ATPUniRule annotation
Metal bindingi147 – 1471MagnesiumUniRule annotation
Metal bindingi151 – 1511MagnesiumUniRule annotation
Binding sitei178 – 1781Ribose-5-phosphateUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi45 – 473ATPUniRule annotation
Nucleotide bindingi104 – 1074ATPUniRule annotation
Nucleotide bindingi151 – 1522ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. kinase activity Source: UniProtKB-KW
  3. magnesium ion binding Source: UniProtKB-HAMAP
  4. ribose phosphate diphosphokinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 5-phosphoribose 1-diphosphate biosynthetic process Source: UniProtKB-UniPathway
  2. nucleotide biosynthetic process Source: UniProtKB-KW
  3. ribonucleoside monophosphate biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationImported, Transferase

Keywords - Biological processi

Nucleotide biosynthesisUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, MagnesiumUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciSVIR471857:GHAV-3224-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribose-phosphate pyrophosphokinaseUniRule annotation (EC:2.7.6.1UniRule annotation)
Short name:
RPPKUniRule annotation
Alternative name(s):
5-phospho-D-ribosyl alpha-1-diphosphateUniRule annotation
Phosphoribosyl diphosphate synthaseUniRule annotation
Phosphoribosyl pyrophosphate synthaseUniRule annotation
Gene namesi
Name:prsUniRule annotation
Ordered Locus Names:Svir_32370Imported
OrganismiSaccharomonospora viridis (strain ATCC 15386 / DSM 43017 / JCM 3036 / NBRC 12207 / P101)Imported
Taxonomic identifieri471857 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesPseudonocardineaePseudonocardiaceaeSaccharomonospora
ProteomesiUP000000841: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi471857.Svir_32370.

Structurei

3D structure databases

ProteinModelPortaliC7MZH9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni202 – 2043Ribose-5-phosphate bindingUniRule annotation
Regioni231 – 2388Ribose-5-phosphate bindingUniRule annotation
Regioni317 – 3193Ribose-5-phosphate bindingUniRule annotation

Sequence similaritiesi

Belongs to the ribose-phosphate pyrophosphokinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0462.
HOGENOMiHOG000210449.
KOiK00948.
OMAiYVQIQES.
OrthoDBiEOG6Z99XQ.

Family and domain databases

Gene3Di3.40.50.2020. 2 hits.
HAMAPiMF_00583_B. RibP_PPkinase_B.
InterProiIPR000842. PRib_PP_synth_CS.
IPR029099. Pribosyltran_N.
IPR029057. PRTase-like.
IPR005946. Rib-P_diPkinase.
[Graphical view]
PfamiPF14572. Pribosyl_synth. 1 hit.
PF13793. Pribosyltran_N. 1 hit.
[Graphical view]
SUPFAMiSSF53271. SSF53271. 1 hit.
TIGRFAMsiTIGR01251. ribP_PPkin. 1 hit.
PROSITEiPS00114. PRPP_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C7MZH9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPKSGTPKK NLMLFSGRSH VELAEEVAKH LNVTITPQTL HSFANGEIYV
60 70 80 90 100
RYQESVRGTD AFVLQSFSPP INEWIMEQLI MVDALKRASA KRITVIMPFY
110 120 130 140 150
PYSRQDKKHK GREPISARLI ADLFKTAGAD RIMTVDLHTA QIQGFFDGPV
160 170 180 190 200
DHLLAQTVLA NYINDTYGDN DITVVSPDSG RVRLAEKWAD QLGSRPIAFI
210 220 230 240 250
HKTRDPDKPN QAVANRVVGE VKGRLCVLID DMIDTGGTIT QAADALMEEG
260 270 280 290 300
AADVVIASTH GILSDPATER LSKSPVREVV VTNTLPIPEE KRIPKLTVLS
310 320
IAPLLARAIQ EVFEDGSVTS LFDGSA
Length:326
Mass (Da):35,783
Last modified:October 13, 2009 - v1
Checksum:iC1BC2B73B066B688
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001683 Genomic DNA. Translation: ACU98208.1.
RefSeqiYP_003135035.1. NC_013159.1.

Genome annotation databases

EnsemblBacteriaiACU98208; ACU98208; Svir_32370.
GeneIDi8388561.
KEGGisvi:Svir_32370.
PATRICi23397042. VBISacVir111818_3296.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001683 Genomic DNA. Translation: ACU98208.1.
RefSeqiYP_003135035.1. NC_013159.1.

3D structure databases

ProteinModelPortaliC7MZH9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi471857.Svir_32370.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACU98208; ACU98208; Svir_32370.
GeneIDi8388561.
KEGGisvi:Svir_32370.
PATRICi23397042. VBISacVir111818_3296.

Phylogenomic databases

eggNOGiCOG0462.
HOGENOMiHOG000210449.
KOiK00948.
OMAiYVQIQES.
OrthoDBiEOG6Z99XQ.

Enzyme and pathway databases

BioCyciSVIR471857:GHAV-3224-MONOMER.

Family and domain databases

Gene3Di3.40.50.2020. 2 hits.
HAMAPiMF_00583_B. RibP_PPkinase_B.
InterProiIPR000842. PRib_PP_synth_CS.
IPR029099. Pribosyltran_N.
IPR029057. PRTase-like.
IPR005946. Rib-P_diPkinase.
[Graphical view]
PfamiPF14572. Pribosyl_synth. 1 hit.
PF13793. Pribosyltran_N. 1 hit.
[Graphical view]
SUPFAMiSSF53271. SSF53271. 1 hit.
TIGRFAMsiTIGR01251. ribP_PPkin. 1 hit.
PROSITEiPS00114. PRPP_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15386 / DSM 43017 / JCM 3036 / NBRC 12207 / P101Imported.

Entry informationi

Entry nameiC7MZH9_SACVD
AccessioniPrimary (citable) accession number: C7MZH9
Entry historyi
Integrated into UniProtKB/TrEMBL: October 13, 2009
Last sequence update: October 13, 2009
Last modified: March 4, 2015
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.