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Protein

Glycerol-3-phosphate dehydrogenase [NAD(P)+]

Gene

gpsA

Organism
Saccharomonospora viridis (strain ATCC 15386 / DSM 43017 / JCM 3036 / NBRC 12207 / P101)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

sn-glycerol 3-phosphate + NAD(P)+ = glycerone phosphate + NAD(P)H.UniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei108 – 1081NAD; via amide nitrogenUniRule annotation
Binding sitei108 – 1081SubstrateUniRule annotation
Binding sitei142 – 1421NAD; via amide nitrogenUniRule annotation
Active sitei193 – 1931Proton acceptorUniRule annotation
Binding sitei257 – 2571NADUniRule annotation
Binding sitei284 – 2841NADUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 156NADUniRule annotation

GO - Molecular functioni

  1. glycerol-3-phosphate dehydrogenase [NAD(P)+] activity Source: UniProtKB-HAMAP
  2. glycerol-3-phosphate dehydrogenase [NAD+] activity Source: UniProtKB-EC
  3. glycerol-3-phosphate dehydrogenase [NADP+] activity Source: UniProtKB-EC
  4. NAD binding Source: InterPro

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
  2. glycerol-3-phosphate biosynthetic process Source: UniProtKB-HAMAP
  3. glycerol-3-phosphate catabolic process Source: InterPro
  4. glycerophospholipid metabolic process Source: UniProtKB-UniPathway
  5. phospholipid biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesisUniRule annotation, Phospholipid metabolism

Keywords - Ligandi

NADUniRule annotation

Enzyme and pathway databases

BioCyciSVIR471857:GHAV-912-MONOMER.
UniPathwayiUPA00940.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol-3-phosphate dehydrogenase [NAD(P)+]UniRule annotation (EC:1.1.1.94UniRule annotation)
Alternative name(s):
NAD(P)H-dependent glycerol-3-phosphate dehydrogenaseUniRule annotation
Gene namesi
Name:gpsAUniRule annotation
Ordered Locus Names:Svir_09130Imported
OrganismiSaccharomonospora viridis (strain ATCC 15386 / DSM 43017 / JCM 3036 / NBRC 12207 / P101)Imported
Taxonomic identifieri471857 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesPseudonocardineaePseudonocardiaceaeSaccharomonospora
ProteomesiUP000000841 Componenti: Chromosome

Subcellular locationi

  1. Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

  1. glycerol-3-phosphate dehydrogenase complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi471857.Svir_09130.

Structurei

3D structure databases

ProteinModelPortaliC7MY23.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni257 – 2582Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0240.
HOGENOMiHOG000246853.
KOiK00057.
OMAiRNHTAGR.
OrthoDBiEOG6JDWF4.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
HAMAPiMF_00394. NAD_Glyc3P_dehydrog.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013328. 6PGD_dom_2.
IPR006168. G3P_DH_NAD-dep.
IPR006109. G3P_DH_NAD-dep_C.
IPR011128. G3P_DH_NAD-dep_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11728. PTHR11728. 1 hit.
PfamiPF07479. NAD_Gly3P_dh_C. 1 hit.
PF01210. NAD_Gly3P_dh_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000114. Glycerol-3-P_dh. 1 hit.
PRINTSiPR00077. GPDHDRGNASE.
SUPFAMiSSF48179. SSF48179. 1 hit.
PROSITEiPS00957. NAD_G3PDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C7MY23-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVQRVTVLG AGSWGTTFAK VLADAGRDVT LWARRAEVAD EIRTQHTNSS
60 70 80 90 100
YLPGVRLPER LTATSDAATA LEAADAVVFA VPSQKLRENL AAWRDLLPAD
110 120 130 140 150
AILVSLAKGV ELGTLKRMSE VISDITGVEP GDVVVVSGPN LAKEIAQQQP
160 170 180 190 200
AAAVLACADH DRAVAIQQAS FNSYFRPYTN TDVVGCELGG ACKNVIALSC
210 220 230 240 250
GMAAGLGYGT NTMATLITRG LAEMARLGAA LGADPLTFAG LAGVGDLVAT
260 270 280 290 300
CSSPLSRNRT FGERIGRGET MEQARAAQGG QVAEGVTSCR SIRELARRLD
310 320 330
VDMPITDAMY RVCHEGVDPG TVGAELLGRR QKHEWS
Length:336
Mass (Da):35,337
Last modified:October 13, 2009 - v1
Checksum:i14A3033E7C3ECACE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001683 Genomic DNA. Translation: ACU95971.1.
RefSeqiYP_003132798.1. NC_013159.1.

Genome annotation databases

EnsemblBacteriaiACU95971; ACU95971; Svir_09130.
KEGGisvi:Svir_09130.
PATRICi23392214. VBISacVir111818_0903.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001683 Genomic DNA. Translation: ACU95971.1.
RefSeqiYP_003132798.1. NC_013159.1.

3D structure databases

ProteinModelPortaliC7MY23.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi471857.Svir_09130.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACU95971; ACU95971; Svir_09130.
KEGGisvi:Svir_09130.
PATRICi23392214. VBISacVir111818_0903.

Phylogenomic databases

eggNOGiCOG0240.
HOGENOMiHOG000246853.
KOiK00057.
OMAiRNHTAGR.
OrthoDBiEOG6JDWF4.

Enzyme and pathway databases

UniPathwayiUPA00940.
BioCyciSVIR471857:GHAV-912-MONOMER.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
HAMAPiMF_00394. NAD_Glyc3P_dehydrog.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013328. 6PGD_dom_2.
IPR006168. G3P_DH_NAD-dep.
IPR006109. G3P_DH_NAD-dep_C.
IPR011128. G3P_DH_NAD-dep_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11728. PTHR11728. 1 hit.
PfamiPF07479. NAD_Gly3P_dh_C. 1 hit.
PF01210. NAD_Gly3P_dh_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000114. Glycerol-3-P_dh. 1 hit.
PRINTSiPR00077. GPDHDRGNASE.
SUPFAMiSSF48179. SSF48179. 1 hit.
PROSITEiPS00957. NAD_G3PDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15386 / DSM 43017 / JCM 3036 / NBRC 12207 / P101Imported.

Entry informationi

Entry nameiC7MY23_SACVD
AccessioniPrimary (citable) accession number: C7MY23
Entry historyi
Integrated into UniProtKB/TrEMBL: October 13, 2009
Last sequence update: October 13, 2009
Last modified: April 29, 2015
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.