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Protein

D-inositol 3-phosphate glycosyltransferase

Gene

mshA

Organism
Saccharomonospora viridis (strain ATCC 15386 / DSM 43017 / JCM 3036 / NBRC 12207 / P101)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2-acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway.UniRule annotation

Catalytic activityi

UDP-N-acetyl-D-glucosamine + 1D-myo-inositol 3-phosphate = UDP + 1-O-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol 3-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei211D-inositol 3-phosphateUniRule annotation1
Binding sitei35UDP-GlcNAc; via amide nitrogenUniRule annotation1
Binding sitei901D-inositol 3-phosphateUniRule annotation1
Binding sitei1231D-inositol 3-phosphateUniRule annotation1
Binding sitei1471D-inositol 3-phosphateUniRule annotation1
Binding sitei1671D-inositol 3-phosphateUniRule annotation1
Binding sitei241UDP-GlcNAcUniRule annotation1
Binding sitei246UDP-GlcNAcUniRule annotation1
Binding sitei307UDP-GlcNAc; via amide nitrogen and carbonyl oxygenUniRule annotation1
Metal bindingi316Magnesium; via carbonyl oxygenUniRule annotation1
Metal bindingi317Magnesium; via carbonyl oxygenUniRule annotation1
Metal bindingi319Magnesium; via carbonyl oxygenUniRule annotation1
Binding sitei329UDP-GlcNAcUniRule annotation1
Binding sitei337UDP-GlcNAcUniRule annotation1
Metal bindingi343MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding

Protein family/group databases

CAZyiGT4. Glycosyltransferase Family 4.

Names & Taxonomyi

Protein namesi
Recommended name:
D-inositol 3-phosphate glycosyltransferase (EC:2.4.1.250UniRule annotation)
Alternative name(s):
N-acetylglucosamine-inositol-phosphate N-acetylglucosaminyltransferaseUniRule annotation
Short name:
GlcNAc-Ins-P N-acetylglucosaminyltransferaseUniRule annotation
Gene namesi
Name:mshAUniRule annotation
Ordered Locus Names:Svir_02650
OrganismiSaccharomonospora viridis (strain ATCC 15386 / DSM 43017 / JCM 3036 / NBRC 12207 / P101)
Taxonomic identifieri471857 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaPseudonocardialesPseudonocardiaceaeSaccharomonospora
Proteomesi
  • UP000000841 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004001541 – 431D-inositol 3-phosphate glycosyltransferaseAdd BLAST431

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi471857.Svir_02650.

Structurei

3D structure databases

ProteinModelPortaliC7MSY6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni27 – 28UDP-GlcNAc bindingUniRule annotation2
Regioni32 – 371D-inositol 3-phosphate bindingUniRule annotation6

Sequence similaritiesi

Belongs to the glycosyltransferase group 1 family. MshA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107R5M. Bacteria.
COG0438. LUCA.
HOGENOMiHOG000077288.
KOiK15521.
OMAiHTMAKVK.
OrthoDBiPOG091H0AO3.

Family and domain databases

HAMAPiMF_01695. MshA. 1 hit.
InterProiIPR001296. Glyco_trans_1.
IPR028098. Glyco_trans_4-like_N.
IPR017814. Mycothiol_biosynthesis_MshA.
[Graphical view]
PfamiPF13439. Glyco_transf_4. 1 hit.
PF00534. Glycos_transf_1. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03449. mycothiol_MshA. 1 hit.

Sequencei

Sequence statusi: Complete.

C7MSY6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTISGYRKAI WPRRIAVLSV HTSPLEQPGT KDAGGMNVYI SQTAVEMARR
60 70 80 90 100
GVSVEVFTRA TSSDQPPAVE LAPGVLVRHI PAGPFEPLER GELPSQLCAF
110 120 130 140 150
TSGVLRTEAF QEPGYYDLIH SHYWLSGQVG WLARDRWGVP LVHTAHTLAK
160 170 180 190 200
VKNAALASGD TPEPRTRVIG EEQVVAEADR LVVNTDVEAD QLVRLYDAAP
210 220 230 240 250
DAVRTVSPGV DLERFRPGSR AAARAALGVP ADAVVLAFAG RIQPLKAPDV
260 270 280 290 300
LLRATAALVR RDPGLRRRLV VLVAGGPSGS GLEQPRSLMD LAVELGIDDV
310 320 330 340 350
TRFLPPQGGQ DLVNVYRAAD VVAVPSHNES FGLVALEAQA CGTPVVAARV
360 370 380 390 400
GGLPVAVDDE VSGLLVPTHD TEDWADALAR VALRPEVRAV LSRGAREHAQ
410 420 430
RFSWRRTTDA LLDIYREAMA AFRGTALEVA V
Length:431
Mass (Da):46,261
Last modified:October 13, 2009 - v1
Checksum:i9E94A9870D477384
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001683 Genomic DNA. Translation: ACU95347.1.
RefSeqiWP_012795780.1. NC_013159.1.

Genome annotation databases

EnsemblBacteriaiACU95347; ACU95347; Svir_02650.
KEGGisvi:Svir_02650.
PATRICi23390906. VBISacVir111818_0263.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001683 Genomic DNA. Translation: ACU95347.1.
RefSeqiWP_012795780.1. NC_013159.1.

3D structure databases

ProteinModelPortaliC7MSY6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi471857.Svir_02650.

Protein family/group databases

CAZyiGT4. Glycosyltransferase Family 4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACU95347; ACU95347; Svir_02650.
KEGGisvi:Svir_02650.
PATRICi23390906. VBISacVir111818_0263.

Phylogenomic databases

eggNOGiENOG4107R5M. Bacteria.
COG0438. LUCA.
HOGENOMiHOG000077288.
KOiK15521.
OMAiHTMAKVK.
OrthoDBiPOG091H0AO3.

Family and domain databases

HAMAPiMF_01695. MshA. 1 hit.
InterProiIPR001296. Glyco_trans_1.
IPR028098. Glyco_trans_4-like_N.
IPR017814. Mycothiol_biosynthesis_MshA.
[Graphical view]
PfamiPF13439. Glyco_transf_4. 1 hit.
PF00534. Glycos_transf_1. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03449. mycothiol_MshA. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMSHA_SACVD
AccessioniPrimary (citable) accession number: C7MSY6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 2, 2010
Last sequence update: October 13, 2009
Last modified: November 2, 2016
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.