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Protein

Mycothiol acetyltransferase

Gene

mshD

Organism
Saccharomonospora viridis (strain ATCC 15386 / DSM 43017 / JCM 3036 / NBRC 12207 / P101)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol.UniRule annotation

Catalytic activityi

Desacetylmycothiol + acetyl-CoA = CoA + mycothiol.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei182DesacetylmycothiolUniRule annotation1
Binding sitei222DesacetylmycothiolUniRule annotation1
Binding sitei238DesacetylmycothiolUniRule annotation1
Binding sitei276Desacetylmycothiol; via carbonyl oxygenUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionAcyltransferase, Transferase

Enzyme and pathway databases

BioCyciSVIR471857:G1GFJ-3738-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Mycothiol acetyltransferaseUniRule annotation (EC:2.3.1.189UniRule annotation)
Short name:
MSH acetyltransferaseUniRule annotation
Alternative name(s):
Mycothiol synthaseUniRule annotation
Gene namesi
Name:mshDUniRule annotation
Ordered Locus Names:Svir_37660
OrganismiSaccharomonospora viridis (strain ATCC 15386 / DSM 43017 / JCM 3036 / NBRC 12207 / P101)
Taxonomic identifieri471857 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaPseudonocardialesPseudonocardiaceaeSaccharomonospora
Proteomesi
  • UP000000841 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004002941 – 306Mycothiol acetyltransferaseAdd BLAST306

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi471857.Svir_37660

Structurei

3D structure databases

ProteinModelPortaliC7MRC4
SMRiC7MRC4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 162N-acetyltransferase 1UniRule annotationAdd BLAST158
Domaini155 – 306N-acetyltransferase 2UniRule annotationAdd BLAST152

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni82 – 84Acetyl-CoA binding 1UniRule annotation3
Regioni90 – 95Acetyl-CoA binding 1UniRule annotation6
Regioni242 – 244Acetyl-CoA binding 2UniRule annotation3
Regioni249 – 255Acetyl-CoA binding 2UniRule annotation7

Sequence similaritiesi

Belongs to the acetyltransferase family. MshD subfamily.UniRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG4108RTV Bacteria
COG0456 LUCA
HOGENOMiHOG000248937
KOiK15520
OMAiAEPWFDP
OrthoDBiPOG091H09IL

Family and domain databases

HAMAPiMF_01698 MshD, 1 hit
InterProiView protein in InterPro
IPR016181 Acyl_CoA_acyltransferase
IPR000182 GNAT_dom
IPR017813 Mycothiol_AcTrfase
PfamiView protein in Pfam
PF00583 Acetyltransf_1, 2 hits
PIRSFiPIRSF021524 MSH_acetyltransferase, 1 hit
SUPFAMiSSF55729 SSF55729, 1 hit
TIGRFAMsiTIGR03448 mycothiol_MshD, 1 hit
PROSITEiView protein in PROSITE
PS51186 GNAT, 2 hits

Sequencei

Sequence statusi: Complete.

C7MRC4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRNFVWAEEL DADRIDDVRA LLLAARETDG RPEVEPDGPL PGEFSGPRHL
60 70 80 90 100
LCFSGEGAAA ELVGYAHLDV RGDAFGRQVA ELIVHPAHRR RGHGTALLEE
110 120 130 140 150
VLRHADRLRI WSHGDHPAAA RLAERFGLSR ARELLVMSAS SAEQEWPKPR
160 170 180 190 200
LPEGVRLRTF VPGQDEEAVI AVNARAFDWH PEQSQFDVKA LREAQRESWF
210 220 230 240 250
DADGFFLAEN AEGRVVGFHW TKVHPANPNR FGGRPVGEVY VVGVDPDAQG
260 270 280 290 300
GGLGKALTLA GLRHLRQRGL EQVILYVEGD NAPAIAVYRK LGFETVETDV

QYAQGS
Length:306
Mass (Da):33,851
Last modified:October 13, 2009 - v1
Checksum:i3B77F18B3CB404CF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001683 Genomic DNA Translation: ACU98710.1
RefSeqiWP_015788019.1, NC_013159.1

Genome annotation databases

EnsemblBacteriaiACU98710; ACU98710; Svir_37660
KEGGisvi:Svir_37660

Similar proteinsi

Entry informationi

Entry nameiMSHD_SACVD
AccessioniPrimary (citable) accession number: C7MRC4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 2, 2010
Last sequence update: October 13, 2009
Last modified: May 23, 2018
This is version 55 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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