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Protein

Mycothiol acetyltransferase

Gene

mshD

Organism
Saccharomonospora viridis (strain ATCC 15386 / DSM 43017 / JCM 3036 / NBRC 12207 / P101)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol.UniRule annotation

Catalytic activityi

Desacetylmycothiol + acetyl-CoA = CoA + mycothiol.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei182 – 1821DesacetylmycothiolUniRule annotation
Binding sitei222 – 2221DesacetylmycothiolUniRule annotation
Binding sitei238 – 2381DesacetylmycothiolUniRule annotation
Binding sitei276 – 2761Desacetylmycothiol; via carbonyl oxygenUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Enzyme and pathway databases

BioCyciSVIR471857:GHAV-3750-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Mycothiol acetyltransferaseUniRule annotation (EC:2.3.1.189UniRule annotation)
Short name:
MSH acetyltransferaseUniRule annotation
Alternative name(s):
Mycothiol synthaseUniRule annotation
Gene namesi
Name:mshDUniRule annotation
Ordered Locus Names:Svir_37660
OrganismiSaccharomonospora viridis (strain ATCC 15386 / DSM 43017 / JCM 3036 / NBRC 12207 / P101)
Taxonomic identifieri471857 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaPseudonocardialesPseudonocardiaceaeSaccharomonospora
Proteomesi
  • UP000000841 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 306306Mycothiol acetyltransferasePRO_0000400294Add
BLAST

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi471857.Svir_37660.

Structurei

3D structure databases

ProteinModelPortaliC7MRC4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini5 – 162158N-acetyltransferase 1UniRule annotationAdd
BLAST
Domaini155 – 306152N-acetyltransferase 2UniRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni82 – 843Acetyl-CoA binding 1UniRule annotation
Regioni90 – 956Acetyl-CoA binding 1UniRule annotation
Regioni242 – 2443Acetyl-CoA binding 2UniRule annotation
Regioni249 – 2557Acetyl-CoA binding 2UniRule annotation

Sequence similaritiesi

Belongs to the acetyltransferase family. MshD subfamily.UniRule annotation
Contains 2 N-acetyltransferase domains.UniRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG4108RTV. Bacteria.
COG0456. LUCA.
HOGENOMiHOG000248937.
KOiK15520.
OMAiMLYVDES.
OrthoDBiEOG69D3BP.

Family and domain databases

Gene3Di3.40.630.30. 2 hits.
HAMAPiMF_01698. MshD.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
IPR017813. Mycothiol_AcTrfase.
[Graphical view]
PfamiPF00583. Acetyltransf_1. 2 hits.
[Graphical view]
PIRSFiPIRSF021524. MSH_acetyltransferase. 1 hit.
SUPFAMiSSF55729. SSF55729. 1 hit.
TIGRFAMsiTIGR03448. mycothiol_MshD. 1 hit.
PROSITEiPS51186. GNAT. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C7MRC4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRNFVWAEEL DADRIDDVRA LLLAARETDG RPEVEPDGPL PGEFSGPRHL
60 70 80 90 100
LCFSGEGAAA ELVGYAHLDV RGDAFGRQVA ELIVHPAHRR RGHGTALLEE
110 120 130 140 150
VLRHADRLRI WSHGDHPAAA RLAERFGLSR ARELLVMSAS SAEQEWPKPR
160 170 180 190 200
LPEGVRLRTF VPGQDEEAVI AVNARAFDWH PEQSQFDVKA LREAQRESWF
210 220 230 240 250
DADGFFLAEN AEGRVVGFHW TKVHPANPNR FGGRPVGEVY VVGVDPDAQG
260 270 280 290 300
GGLGKALTLA GLRHLRQRGL EQVILYVEGD NAPAIAVYRK LGFETVETDV

QYAQGS
Length:306
Mass (Da):33,851
Last modified:October 13, 2009 - v1
Checksum:i3B77F18B3CB404CF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001683 Genomic DNA. Translation: ACU98710.1.
RefSeqiWP_015788019.1. NC_013159.1.

Genome annotation databases

EnsemblBacteriaiACU98710; ACU98710; Svir_37660.
KEGGisvi:Svir_37660.
PATRICi23398132. VBISacVir111818_3830.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001683 Genomic DNA. Translation: ACU98710.1.
RefSeqiWP_015788019.1. NC_013159.1.

3D structure databases

ProteinModelPortaliC7MRC4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi471857.Svir_37660.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACU98710; ACU98710; Svir_37660.
KEGGisvi:Svir_37660.
PATRICi23398132. VBISacVir111818_3830.

Phylogenomic databases

eggNOGiENOG4108RTV. Bacteria.
COG0456. LUCA.
HOGENOMiHOG000248937.
KOiK15520.
OMAiMLYVDES.
OrthoDBiEOG69D3BP.

Enzyme and pathway databases

BioCyciSVIR471857:GHAV-3750-MONOMER.

Family and domain databases

Gene3Di3.40.630.30. 2 hits.
HAMAPiMF_01698. MshD.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
IPR017813. Mycothiol_AcTrfase.
[Graphical view]
PfamiPF00583. Acetyltransf_1. 2 hits.
[Graphical view]
PIRSFiPIRSF021524. MSH_acetyltransferase. 1 hit.
SUPFAMiSSF55729. SSF55729. 1 hit.
TIGRFAMsiTIGR03448. mycothiol_MshD. 1 hit.
PROSITEiPS51186. GNAT. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15386 / DSM 43017 / JCM 3036 / NBRC 12207 / P101.

Entry informationi

Entry nameiMSHD_SACVD
AccessioniPrimary (citable) accession number: C7MRC4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 2, 2010
Last sequence update: October 13, 2009
Last modified: November 11, 2015
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.