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Protein

NAD kinase

Gene

nadK

Organism
Cryptobacterium curtum (strain ATCC 700683 / DSM 15641 / 12-3)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotationSAAS annotation

Cofactori

a divalent metal cationUniRule annotationSAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei57 – 571Proton acceptorUniRule annotation
Binding sitei62 – 621NADUniRule annotation
Binding sitei181 – 1811NADUniRule annotation
Binding sitei183 – 1831NADUniRule annotation
Binding sitei218 – 2181NAD; via carbonyl oxygenUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi57 – 582NADUniRule annotation
Nucleotide bindingi153 – 1542NADUniRule annotation
Nucleotide bindingi194 – 1996NADUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationSAAS annotation, Transferase

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, NADUniRule annotationSAAS annotation, NADPUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciCCUR469378:GH4Z-963-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotationSAAS annotation (EC:2.7.1.23UniRule annotationSAAS annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:Ccur_09610Imported
OrganismiCryptobacterium curtum (strain ATCC 700683 / DSM 15641 / 12-3)Imported
Taxonomic identifieri469378 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCoriobacteriiaEggerthellalesEggerthellaceaeCryptobacterium
ProteomesiUP000000954 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi469378.Ccur_09610.

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0061.
HOGENOMiHOG000227221.
KOiK00858.
OMAiRIAHEIF.
OrthoDBiEOG6PZXDR.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR016064. NAD/diacylglycerol_kinase.
IPR002504. NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

C7MP17-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRILIMRNAE SPAAIDASLM LGAYLSSQDI EFTLADAADP EGIIASSFDM
60 70 80 90 100
AVALGGDGTI LRTAKMIRYS RVPILGINYG HLGFLANGNQ GGVVAASAAA
110 120 130 140 150
LAGDTVAEER TNLRIFVQCE GDDDDQYESM CAGDADASID DDFAISRCLF
160 170 180 190 200
ALNEAALTRG ALGWMIDCEL SISGSLVGTV RGDGMVISTA TGSTAYALSA
210 220 230 240 250
GGPLVAPNFR GLVVVPVAPH SLIARAVVTD PHDIVELTLG DTRGDHEAQL
260 270 280 290 300
FVDGLAVEFP APIKRLRVQR GPEPTILLRY QGESFYTLLR TTFFEHTEPV

D
Length:301
Mass (Da):31,868
Last modified:October 13, 2009 - v1
Checksum:iA4A06358E8948815
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001682 Genomic DNA. Translation: ACU94657.1.
RefSeqiWP_012803343.1. NC_013170.1.
YP_003151339.1. NC_013170.1.

Genome annotation databases

EnsemblBacteriaiACU94657; ACU94657; Ccur_09610.
KEGGiccu:Ccur_09610.
PATRICi21525725. VBICryCur116861_0917.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001682 Genomic DNA. Translation: ACU94657.1.
RefSeqiWP_012803343.1. NC_013170.1.
YP_003151339.1. NC_013170.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi469378.Ccur_09610.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACU94657; ACU94657; Ccur_09610.
KEGGiccu:Ccur_09610.
PATRICi21525725. VBICryCur116861_0917.

Phylogenomic databases

eggNOGiCOG0061.
HOGENOMiHOG000227221.
KOiK00858.
OMAiRIAHEIF.
OrthoDBiEOG6PZXDR.

Enzyme and pathway databases

BioCyciCCUR469378:GH4Z-963-MONOMER.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR016064. NAD/diacylglycerol_kinase.
IPR002504. NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700683 / DSM 15641 / 12-3Imported.

Entry informationi

Entry nameiC7MP17_CRYCD
AccessioniPrimary (citable) accession number: C7MP17
Entry historyi
Integrated into UniProtKB/TrEMBL: October 13, 2009
Last sequence update: October 13, 2009
Last modified: June 24, 2015
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.