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C7MP17

- C7MP17_CRYCD

UniProt

C7MP17 - C7MP17_CRYCD

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Protein

NAD kinase

Gene

nadK

Organism
Cryptobacterium curtum (strain ATCC 700683 / DSM 15641 / 12-3)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotationSAAS annotation

Cofactori

Note: Divalent metal ions.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei57 – 571Proton acceptorUniRule annotation
Binding sitei62 – 621NADUniRule annotation
Binding sitei181 – 1811NADUniRule annotation
Binding sitei183 – 1831NADUniRule annotation
Binding sitei218 – 2181NAD; via carbonyl oxygenUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi57 – 582NADUniRule annotation
Nucleotide bindingi153 – 1542NADUniRule annotation
Nucleotide bindingi194 – 1996NADUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-HAMAP
  3. NAD+ kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. NAD metabolic process Source: InterPro
  2. NADP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationSAAS annotation, Transferase

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, NADUniRule annotationSAAS annotation, NADPUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciCCUR469378:GH4Z-963-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotationSAAS annotation (EC:2.7.1.23UniRule annotationSAAS annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:Ccur_09610Imported
OrganismiCryptobacterium curtum (strain ATCC 700683 / DSM 15641 / 12-3)Imported
Taxonomic identifieri469378 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCoriobacteridaeCoriobacterialesCoriobacterineaeCoriobacteriaceaeCryptobacterium
ProteomesiUP000000954: Chromosome

Subcellular locationi

Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi469378.Ccur_09610.

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0061.
HOGENOMiHOG000227221.
KOiK00858.
OMAiAYENGNN.
OrthoDBiEOG6PZXDR.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

C7MP17-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRILIMRNAE SPAAIDASLM LGAYLSSQDI EFTLADAADP EGIIASSFDM
60 70 80 90 100
AVALGGDGTI LRTAKMIRYS RVPILGINYG HLGFLANGNQ GGVVAASAAA
110 120 130 140 150
LAGDTVAEER TNLRIFVQCE GDDDDQYESM CAGDADASID DDFAISRCLF
160 170 180 190 200
ALNEAALTRG ALGWMIDCEL SISGSLVGTV RGDGMVISTA TGSTAYALSA
210 220 230 240 250
GGPLVAPNFR GLVVVPVAPH SLIARAVVTD PHDIVELTLG DTRGDHEAQL
260 270 280 290 300
FVDGLAVEFP APIKRLRVQR GPEPTILLRY QGESFYTLLR TTFFEHTEPV

D
Length:301
Mass (Da):31,868
Last modified:October 13, 2009 - v1
Checksum:iA4A06358E8948815
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001682 Genomic DNA. Translation: ACU94657.1.
RefSeqiYP_003151339.1. NC_013170.1.

Genome annotation databases

EnsemblBacteriaiACU94657; ACU94657; Ccur_09610.
GeneIDi8375168.
KEGGiccu:Ccur_09610.
PATRICi21525725. VBICryCur116861_0917.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001682 Genomic DNA. Translation: ACU94657.1 .
RefSeqi YP_003151339.1. NC_013170.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 469378.Ccur_09610.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACU94657 ; ACU94657 ; Ccur_09610 .
GeneIDi 8375168.
KEGGi ccu:Ccur_09610.
PATRICi 21525725. VBICryCur116861_0917.

Phylogenomic databases

eggNOGi COG0061.
HOGENOMi HOG000227221.
KOi K00858.
OMAi AYENGNN.
OrthoDBi EOG6PZXDR.

Enzyme and pathway databases

BioCyci CCUR469378:GH4Z-963-MONOMER.

Family and domain databases

Gene3Di 2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPi MF_00361. NAD_kinase.
InterProi IPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view ]
PANTHERi PTHR20275. PTHR20275. 1 hit.
Pfami PF01513. NAD_kinase. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700683 / DSM 15641 / 12-3Imported.

Entry informationi

Entry nameiC7MP17_CRYCD
AccessioniPrimary (citable) accession number: C7MP17
Entry historyi
Integrated into UniProtKB/TrEMBL: October 13, 2009
Last sequence update: October 13, 2009
Last modified: November 26, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3