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C7MP17

- C7MP17_CRYCD

UniProt

C7MP17 - C7MP17_CRYCD

Protein

NAD kinase

Gene

nadK

Organism
Cryptobacterium curtum (strain ATCC 700683 / DSM 15641 / 12-3)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 31 (01 Oct 2014)
      Sequence version 1 (13 Oct 2009)
      Previous versions | rss
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    Functioni

    Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

    Catalytic activityi

    ATP + NAD+ = ADP + NADP+.UniRule annotationSAAS annotation

    Cofactori

    Divalent metal ions.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei57 – 571Proton acceptorUniRule annotation
    Binding sitei62 – 621NADUniRule annotation
    Binding sitei181 – 1811NADUniRule annotation
    Binding sitei183 – 1831NADUniRule annotation
    Binding sitei218 – 2181NAD; via carbonyl oxygenUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi57 – 582NADUniRule annotation
    Nucleotide bindingi153 – 1542NADUniRule annotation
    Nucleotide bindingi194 – 1996NADUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-HAMAP
    3. NAD+ kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. NAD metabolic process Source: InterPro
    2. NADP biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    KinaseUniRule annotationSAAS annotationImported, Transferase

    Keywords - Ligandi

    ATP-bindingUniRule annotationSAAS annotation, NADUniRule annotationSAAS annotation, NADPUniRule annotationSAAS annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCCUR469378:GH4Z-963-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
    Alternative name(s):
    ATP-dependent NAD kinaseUniRule annotation
    Gene namesi
    Name:nadKUniRule annotation
    Ordered Locus Names:Ccur_09610Imported
    OrganismiCryptobacterium curtum (strain ATCC 700683 / DSM 15641 / 12-3)Imported
    Taxonomic identifieri469378 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaCoriobacteridaeCoriobacterialesCoriobacterineaeCoriobacteriaceaeCryptobacterium
    ProteomesiUP000000954: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotationSAAS annotation

    Interactioni

    Protein-protein interaction databases

    STRINGi469378.Ccur_09610.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NAD kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0061.
    HOGENOMiHOG000227221.
    KOiK00858.
    OMAiAYENGNN.
    OrthoDBiEOG6PZXDR.

    Family and domain databases

    Gene3Di2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPiMF_00361. NAD_kinase.
    InterProiIPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view]
    PANTHERiPTHR20275. PTHR20275. 1 hit.
    PfamiPF01513. NAD_kinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF111331. SSF111331. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    C7MP17-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRILIMRNAE SPAAIDASLM LGAYLSSQDI EFTLADAADP EGIIASSFDM    50
    AVALGGDGTI LRTAKMIRYS RVPILGINYG HLGFLANGNQ GGVVAASAAA 100
    LAGDTVAEER TNLRIFVQCE GDDDDQYESM CAGDADASID DDFAISRCLF 150
    ALNEAALTRG ALGWMIDCEL SISGSLVGTV RGDGMVISTA TGSTAYALSA 200
    GGPLVAPNFR GLVVVPVAPH SLIARAVVTD PHDIVELTLG DTRGDHEAQL 250
    FVDGLAVEFP APIKRLRVQR GPEPTILLRY QGESFYTLLR TTFFEHTEPV 300
    D 301
    Length:301
    Mass (Da):31,868
    Last modified:October 13, 2009 - v1
    Checksum:iA4A06358E8948815
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001682 Genomic DNA. Translation: ACU94657.1.
    RefSeqiYP_003151339.1. NC_013170.1.

    Genome annotation databases

    EnsemblBacteriaiACU94657; ACU94657; Ccur_09610.
    GeneIDi8375168.
    KEGGiccu:Ccur_09610.
    PATRICi21525725. VBICryCur116861_0917.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001682 Genomic DNA. Translation: ACU94657.1 .
    RefSeqi YP_003151339.1. NC_013170.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 469378.Ccur_09610.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACU94657 ; ACU94657 ; Ccur_09610 .
    GeneIDi 8375168.
    KEGGi ccu:Ccur_09610.
    PATRICi 21525725. VBICryCur116861_0917.

    Phylogenomic databases

    eggNOGi COG0061.
    HOGENOMi HOG000227221.
    KOi K00858.
    OMAi AYENGNN.
    OrthoDBi EOG6PZXDR.

    Enzyme and pathway databases

    BioCyci CCUR469378:GH4Z-963-MONOMER.

    Family and domain databases

    Gene3Di 2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPi MF_00361. NAD_kinase.
    InterProi IPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view ]
    PANTHERi PTHR20275. PTHR20275. 1 hit.
    Pfami PF01513. NAD_kinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF111331. SSF111331. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700683 / DSM 15641 / 12-3Imported.

    Entry informationi

    Entry nameiC7MP17_CRYCD
    AccessioniPrimary (citable) accession number: C7MP17
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 13, 2009
    Last sequence update: October 13, 2009
    Last modified: October 1, 2014
    This is version 31 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3