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Protein

Alanine racemase

Gene

Ccur_01510

Organism
Cryptobacterium curtum (strain ATCC 700683 / DSM 15641 / 12-3)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei80 – 801Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei178 – 1781SubstrateUniRule annotation
Active sitei307 – 3071Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei355 – 3551Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciCCUR469378:GH4Z-152-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:Ccur_01510Imported
OrganismiCryptobacterium curtum (strain ATCC 700683 / DSM 15641 / 12-3)Imported
Taxonomic identifieri469378 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCoriobacteridaeCoriobacterialesCoriobacterineaeCoriobacteriaceaeCryptobacterium
ProteomesiUP000000954: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei80 – 801N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi469378.Ccur_01510.

Structurei

3D structure databases

ProteinModelPortaliC7MLS7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0787.
HOGENOMiHOG000031444.
KOiK01775.
OMAiITMDQLM.
OrthoDBiEOG6PP9NJ.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C7MLS7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDDTLNGFTG FSRKDDPLRY ADADTQAASP VSFSKEALAS IAGEDRRWAW
60 70 80 90 100
VEIDRSAIRH NLHEAKRRLQ PNCRLMAVVK ADAYGHGAVE VSRTALNSGA
110 120 130 140 150
DALAVATVDE GIALREAGLR APILLLSEPP QAAIPLLLEY KIMPSVYRAE
160 170 180 190 200
FALAYGEIAD AHHLKAPFHL AVNTGMNRIG VHAEDILEFE RQISFHRALE
210 220 230 240 250
QEGTFTHFAT ADCPENLDFR IQMKRFTEAI EALRLAGIDP GIVHAANSAA
260 270 280 290 300
LLRYPESHFD MARIGIAMYG FHPCEETRDV VDLKPAMSVY ARITDIRNVS
310 320 330 340 350
VGEGVSYGLN YRSPGSVRIC TIPLGYADGF NRLLSGKVNV ILDGQYCRQV
360 370 380 390 400
GNICMDQCMF EVDMRTYGTH PRLNPQLGDI VTVVGNQGDA ITTITEMAYL
410 420
ANTIEHEVAI GFAWRLPRLY R
Length:421
Mass (Da):46,578
Last modified:October 13, 2009 - v1
Checksum:i76AD802B3C331C18
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001682 Genomic DNA. Translation: ACU93883.1.
RefSeqiYP_003150565.1. NC_013170.1.

Genome annotation databases

EnsemblBacteriaiACU93883; ACU93883; Ccur_01510.
GeneIDi8374359.
KEGGiccu:Ccur_01510.
PATRICi21524135. VBICryCur116861_0153.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001682 Genomic DNA. Translation: ACU93883.1.
RefSeqiYP_003150565.1. NC_013170.1.

3D structure databases

ProteinModelPortaliC7MLS7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi469378.Ccur_01510.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACU93883; ACU93883; Ccur_01510.
GeneIDi8374359.
KEGGiccu:Ccur_01510.
PATRICi21524135. VBICryCur116861_0153.

Phylogenomic databases

eggNOGiCOG0787.
HOGENOMiHOG000031444.
KOiK01775.
OMAiITMDQLM.
OrthoDBiEOG6PP9NJ.

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.
BioCyciCCUR469378:GH4Z-152-MONOMER.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700683 / DSM 15641 / 12-3Imported.

Entry informationi

Entry nameiC7MLS7_CRYCD
AccessioniPrimary (citable) accession number: C7MLS7
Entry historyi
Integrated into UniProtKB/TrEMBL: October 13, 2009
Last sequence update: October 13, 2009
Last modified: February 4, 2015
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.