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C7MGG4

- C7MGG4_BRAFD

UniProt

C7MGG4 - C7MGG4_BRAFD

Protein

Endonuclease III

Gene

nth

Organism
Brachybacterium faecium (strain ATCC 43885 / DSM 4810 / NCIB 9860)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 35 (01 Oct 2014)
      Sequence version 1 (13 Oct 2009)
      Previous versions | rss
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    Functioni

    DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity.UniRule annotation
    DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.UniRule annotation

    Catalytic activityi

    The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.UniRule annotation

    Cofactori

    Binds 1 4Fe-4S cluster.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi208 – 2081Iron-sulfur (4Fe-4S)UniRule annotation
    Metal bindingi215 – 2151Iron-sulfur (4Fe-4S)UniRule annotation
    Metal bindingi218 – 2181Iron-sulfur (4Fe-4S)UniRule annotation
    Metal bindingi224 – 2241Iron-sulfur (4Fe-4S)UniRule annotation

    GO - Molecular functioni

    1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-HAMAP
    2. DNA-(apurinic or apyrimidinic site) lyase activity Source: UniProtKB-HAMAP
    3. DNA binding Source: UniProtKB-HAMAP
    4. DNA N-glycosylase activity Source: UniProtKB-HAMAP
    5. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. base-excision repair Source: InterPro

    Keywords - Molecular functioni

    EndonucleaseImported, GlycosidaseUniRule annotation, Hydrolase, LyaseUniRule annotation, Nuclease

    Keywords - Biological processi

    DNA damage, DNA repairUniRule annotation

    Keywords - Ligandi

    4Fe-4SUniRule annotation, DNA-bindingUniRule annotation, Iron, Iron-sulfur, Metal-binding

    Enzyme and pathway databases

    BioCyciBFAE446465:GH3P-2617-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Endonuclease IIIUniRule annotation (EC:4.2.99.18UniRule annotation)
    Alternative name(s):
    DNA-(apurinic or apyrimidinic site) lyaseUniRule annotation
    Gene namesi
    Name:nthUniRule annotation
    Ordered Locus Names:Bfae_26220Imported
    OrganismiBrachybacterium faecium (strain ATCC 43885 / DSM 4810 / NCIB 9860)Imported
    Taxonomic identifieri446465 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeDermabacteraceaeBrachybacterium
    ProteomesiUP000001919: Chromosome

    Interactioni

    Protein-protein interaction databases

    STRINGi446465.Bfae_26220.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini113 – 14028HhHUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the Nth/MutY family.UniRule annotation
    Contains 1 HhH domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0177.
    HOGENOMiHOG000252208.
    KOiK10773.
    OMAiNCSIDIL.
    OrthoDBiEOG6H4KC5.

    Family and domain databases

    Gene3Di1.10.1670.10. 1 hit.
    1.10.340.30. 1 hit.
    HAMAPiMF_00942. Nth.
    InterProiIPR011257. DNA_glycosylase.
    IPR003651. Endouclease3_FeS-loop_motif.
    IPR003265. HhH-GPD_domain.
    IPR000445. HhH_motif.
    IPR023170. HTH_base_excis_C.
    IPR005759. Nth.
    [Graphical view]
    PfamiPF00633. HHH. 1 hit.
    PF00730. HhH-GPD. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001435. Nth. 1 hit.
    SMARTiSM00478. ENDO3c. 1 hit.
    SM00525. FES. 1 hit.
    [Graphical view]
    SUPFAMiSSF48150. SSF48150. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    C7MGG4-1 [UniParc]FASTAAdd to Basket

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    MSMSTPRSTD LPRPAGPADA SRVASRLAAL HAEARTELDH RDAFELLVAT    50
    VLSAQTTDVR VNQVTPELFS RWPDPAALAA ADEGAVTEVV RPLGMGATRA 100
    RRLIGLAQGL LARHGGEVPD DQAALEALPG VGRKTAHVVR GAWFGHSLLA 150
    VDTHVGRLAQ RLGWTTATTP RRVEEDVVAR VEADGTGAPE EDLTILGLRL 200
    ILHGRRVCTA RAPRCGQCAL VDLCPREGVA 230
    Length:230
    Mass (Da):24,427
    Last modified:October 13, 2009 - v1
    Checksum:i53F7EF229EEEBEE0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001643 Genomic DNA. Translation: ACU86397.1.
    RefSeqiWP_015776601.1. NC_013172.1.
    YP_003155987.1. NC_013172.1.

    Genome annotation databases

    EnsemblBacteriaiACU86397; ACU86397; Bfae_26220.
    GeneIDi8401167.
    KEGGibfa:Bfae_26220.
    PATRICi21176923. VBIBraFae133938_2585.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001643 Genomic DNA. Translation: ACU86397.1 .
    RefSeqi WP_015776601.1. NC_013172.1.
    YP_003155987.1. NC_013172.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 446465.Bfae_26220.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACU86397 ; ACU86397 ; Bfae_26220 .
    GeneIDi 8401167.
    KEGGi bfa:Bfae_26220.
    PATRICi 21176923. VBIBraFae133938_2585.

    Phylogenomic databases

    eggNOGi COG0177.
    HOGENOMi HOG000252208.
    KOi K10773.
    OMAi NCSIDIL.
    OrthoDBi EOG6H4KC5.

    Enzyme and pathway databases

    BioCyci BFAE446465:GH3P-2617-MONOMER.

    Family and domain databases

    Gene3Di 1.10.1670.10. 1 hit.
    1.10.340.30. 1 hit.
    HAMAPi MF_00942. Nth.
    InterProi IPR011257. DNA_glycosylase.
    IPR003651. Endouclease3_FeS-loop_motif.
    IPR003265. HhH-GPD_domain.
    IPR000445. HhH_motif.
    IPR023170. HTH_base_excis_C.
    IPR005759. Nth.
    [Graphical view ]
    Pfami PF00633. HHH. 1 hit.
    PF00730. HhH-GPD. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001435. Nth. 1 hit.
    SMARTi SM00478. ENDO3c. 1 hit.
    SM00525. FES. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48150. SSF48150. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 43885 / DSM 4810 / NCIB 9860Imported.

    Entry informationi

    Entry nameiC7MGG4_BRAFD
    AccessioniPrimary (citable) accession number: C7MGG4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 13, 2009
    Last sequence update: October 13, 2009
    Last modified: October 1, 2014
    This is version 35 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3