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C7MGG4

- C7MGG4_BRAFD

UniProt

C7MGG4 - C7MGG4_BRAFD

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Protein

Endonuclease III

Gene
nth, Bfae_26220
Organism
Brachybacterium faecium (strain ATCC 43885 / DSM 4810 / NCIB 9860)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity By similarity.UniRule annotation
DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate By similarity.UniRule annotation

Catalytic activityi

The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.UniRule annotation

Cofactori

Binds 1 4Fe-4S cluster By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi208 – 2081Iron-sulfur (4Fe-4S) By similarityUniRule annotation
Metal bindingi215 – 2151Iron-sulfur (4Fe-4S) By similarityUniRule annotation
Metal bindingi218 – 2181Iron-sulfur (4Fe-4S) By similarityUniRule annotation
Metal bindingi224 – 2241Iron-sulfur (4Fe-4S) By similarityUniRule annotation

GO - Molecular functioni

  1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-HAMAP
  2. DNA-(apurinic or apyrimidinic site) lyase activity Source: UniProtKB-HAMAP
  3. DNA binding Source: UniProtKB-HAMAP
  4. DNA N-glycosylase activity Source: UniProtKB-HAMAP
  5. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. base-excision repair Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

EndonucleaseImported, GlycosidaseUniRule annotation, Hydrolase, LyaseUniRule annotation, Nuclease

Keywords - Biological processi

DNA damage, DNA repairUniRule annotation

Keywords - Ligandi

4Fe-4SUniRule annotation, DNA-bindingUniRule annotation, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

BioCyciBFAE446465:GH3P-2617-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Endonuclease IIIUniRule annotation (EC:4.2.99.18UniRule annotation)
Alternative name(s):
DNA-(apurinic or apyrimidinic site) lyase
Gene namesi
Name:nthUniRule annotation
Ordered Locus Names:Bfae_26220Imported
OrganismiBrachybacterium faecium (strain ATCC 43885 / DSM 4810 / NCIB 9860)Imported
Taxonomic identifieri446465 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeDermabacteraceaeBrachybacterium
ProteomesiUP000001919: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi446465.Bfae_26220.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini113 – 14028HhH By similarityUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the Nth/MutY family.UniRule annotation
Contains 1 HhH domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG0177.
HOGENOMiHOG000252208.
KOiK10773.
OMAiNCSIDIL.
OrthoDBiEOG6H4KC5.

Family and domain databases

Gene3Di1.10.1670.10. 1 hit.
1.10.340.30. 1 hit.
HAMAPiMF_00942. Nth.
InterProiIPR011257. DNA_glycosylase.
IPR003651. Endouclease3_FeS-loop_motif.
IPR003265. HhH-GPD_domain.
IPR000445. HhH_motif.
IPR023170. HTH_base_excis_C.
IPR005759. Nth.
[Graphical view]
PfamiPF00633. HHH. 1 hit.
PF00730. HhH-GPD. 1 hit.
[Graphical view]
PIRSFiPIRSF001435. Nth. 1 hit.
SMARTiSM00478. ENDO3c. 1 hit.
SM00525. FES. 1 hit.
[Graphical view]
SUPFAMiSSF48150. SSF48150. 1 hit.

Sequencei

Sequence statusi: Complete.

C7MGG4-1 [UniParc]FASTAAdd to Basket

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MSMSTPRSTD LPRPAGPADA SRVASRLAAL HAEARTELDH RDAFELLVAT    50
VLSAQTTDVR VNQVTPELFS RWPDPAALAA ADEGAVTEVV RPLGMGATRA 100
RRLIGLAQGL LARHGGEVPD DQAALEALPG VGRKTAHVVR GAWFGHSLLA 150
VDTHVGRLAQ RLGWTTATTP RRVEEDVVAR VEADGTGAPE EDLTILGLRL 200
ILHGRRVCTA RAPRCGQCAL VDLCPREGVA 230
Length:230
Mass (Da):24,427
Last modified:October 13, 2009 - v1
Checksum:i53F7EF229EEEBEE0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001643 Genomic DNA. Translation: ACU86397.1.
RefSeqiWP_015776601.1. NC_013172.1.
YP_003155987.1. NC_013172.1.

Genome annotation databases

EnsemblBacteriaiACU86397; ACU86397; Bfae_26220.
GeneIDi8401167.
KEGGibfa:Bfae_26220.
PATRICi21176923. VBIBraFae133938_2585.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001643 Genomic DNA. Translation: ACU86397.1 .
RefSeqi WP_015776601.1. NC_013172.1.
YP_003155987.1. NC_013172.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 446465.Bfae_26220.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACU86397 ; ACU86397 ; Bfae_26220 .
GeneIDi 8401167.
KEGGi bfa:Bfae_26220.
PATRICi 21176923. VBIBraFae133938_2585.

Phylogenomic databases

eggNOGi COG0177.
HOGENOMi HOG000252208.
KOi K10773.
OMAi NCSIDIL.
OrthoDBi EOG6H4KC5.

Enzyme and pathway databases

BioCyci BFAE446465:GH3P-2617-MONOMER.

Family and domain databases

Gene3Di 1.10.1670.10. 1 hit.
1.10.340.30. 1 hit.
HAMAPi MF_00942. Nth.
InterProi IPR011257. DNA_glycosylase.
IPR003651. Endouclease3_FeS-loop_motif.
IPR003265. HhH-GPD_domain.
IPR000445. HhH_motif.
IPR023170. HTH_base_excis_C.
IPR005759. Nth.
[Graphical view ]
Pfami PF00633. HHH. 1 hit.
PF00730. HhH-GPD. 1 hit.
[Graphical view ]
PIRSFi PIRSF001435. Nth. 1 hit.
SMARTi SM00478. ENDO3c. 1 hit.
SM00525. FES. 1 hit.
[Graphical view ]
SUPFAMi SSF48150. SSF48150. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43885 / DSM 4810 / NCIB 9860.

Entry informationi

Entry nameiC7MGG4_BRAFD
AccessioniPrimary (citable) accession number: C7MGG4
Entry historyi
Integrated into UniProtKB/TrEMBL: October 13, 2009
Last sequence update: October 13, 2009
Last modified: September 3, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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