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C7MGG4

- C7MGG4_BRAFD

UniProt

C7MGG4 - C7MGG4_BRAFD

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Protein

Endonuclease III

Gene

nth

Organism
Brachybacterium faecium (strain ATCC 43885 / DSM 4810 / NCIB 9860)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity.UniRule annotation
DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.UniRule annotation

Catalytic activityi

The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.UniRule annotation

Cofactori

Note: Binds 1 4Fe-4S cluster.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi208 – 2081Iron-sulfur (4Fe-4S)UniRule annotation
Metal bindingi215 – 2151Iron-sulfur (4Fe-4S)UniRule annotation
Metal bindingi218 – 2181Iron-sulfur (4Fe-4S)UniRule annotation
Metal bindingi224 – 2241Iron-sulfur (4Fe-4S)UniRule annotation

GO - Molecular functioni

  1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-HAMAP
  2. DNA-(apurinic or apyrimidinic site) lyase activity Source: UniProtKB-HAMAP
  3. DNA binding Source: UniProtKB-HAMAP
  4. DNA N-glycosylase activity Source: UniProtKB-HAMAP
  5. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. base-excision repair Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

EndonucleaseImported, GlycosidaseUniRule annotation, Hydrolase, LyaseUniRule annotation, Nuclease

Keywords - Biological processi

DNA damage, DNA repairUniRule annotation

Keywords - Ligandi

4Fe-4SUniRule annotation, DNA-bindingUniRule annotation, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

BioCyciBFAE446465:GH3P-2617-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Endonuclease IIIUniRule annotation (EC:4.2.99.18UniRule annotation)
Alternative name(s):
DNA-(apurinic or apyrimidinic site) lyaseUniRule annotation
Gene namesi
Name:nthUniRule annotation
Ordered Locus Names:Bfae_26220Imported
OrganismiBrachybacterium faecium (strain ATCC 43885 / DSM 4810 / NCIB 9860)Imported
Taxonomic identifieri446465 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeDermabacteraceaeBrachybacterium
ProteomesiUP000001919: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi446465.Bfae_26220.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini113 – 14028HhHUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the Nth/MutY family.UniRule annotation
Contains 1 HhH domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG0177.
HOGENOMiHOG000252208.
KOiK10773.
OMAiNCSIDIL.
OrthoDBiEOG6H4KC5.

Family and domain databases

Gene3Di1.10.1670.10. 1 hit.
1.10.340.30. 1 hit.
HAMAPiMF_00942. Nth.
InterProiIPR011257. DNA_glycosylase.
IPR003651. Endouclease3_FeS-loop_motif.
IPR003265. HhH-GPD_domain.
IPR000445. HhH_motif.
IPR023170. HTH_base_excis_C.
IPR005759. Nth.
[Graphical view]
PfamiPF00633. HHH. 1 hit.
PF00730. HhH-GPD. 1 hit.
[Graphical view]
PIRSFiPIRSF001435. Nth. 1 hit.
SMARTiSM00478. ENDO3c. 1 hit.
SM00525. FES. 1 hit.
[Graphical view]
SUPFAMiSSF48150. SSF48150. 1 hit.

Sequencei

Sequence statusi: Complete.

C7MGG4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSMSTPRSTD LPRPAGPADA SRVASRLAAL HAEARTELDH RDAFELLVAT
60 70 80 90 100
VLSAQTTDVR VNQVTPELFS RWPDPAALAA ADEGAVTEVV RPLGMGATRA
110 120 130 140 150
RRLIGLAQGL LARHGGEVPD DQAALEALPG VGRKTAHVVR GAWFGHSLLA
160 170 180 190 200
VDTHVGRLAQ RLGWTTATTP RRVEEDVVAR VEADGTGAPE EDLTILGLRL
210 220 230
ILHGRRVCTA RAPRCGQCAL VDLCPREGVA
Length:230
Mass (Da):24,427
Last modified:October 13, 2009 - v1
Checksum:i53F7EF229EEEBEE0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001643 Genomic DNA. Translation: ACU86397.1.
RefSeqiWP_015776601.1. NC_013172.1.
YP_003155987.1. NC_013172.1.

Genome annotation databases

EnsemblBacteriaiACU86397; ACU86397; Bfae_26220.
GeneIDi8401167.
KEGGibfa:Bfae_26220.
PATRICi21176923. VBIBraFae133938_2585.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001643 Genomic DNA. Translation: ACU86397.1 .
RefSeqi WP_015776601.1. NC_013172.1.
YP_003155987.1. NC_013172.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 446465.Bfae_26220.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACU86397 ; ACU86397 ; Bfae_26220 .
GeneIDi 8401167.
KEGGi bfa:Bfae_26220.
PATRICi 21176923. VBIBraFae133938_2585.

Phylogenomic databases

eggNOGi COG0177.
HOGENOMi HOG000252208.
KOi K10773.
OMAi NCSIDIL.
OrthoDBi EOG6H4KC5.

Enzyme and pathway databases

BioCyci BFAE446465:GH3P-2617-MONOMER.

Family and domain databases

Gene3Di 1.10.1670.10. 1 hit.
1.10.340.30. 1 hit.
HAMAPi MF_00942. Nth.
InterProi IPR011257. DNA_glycosylase.
IPR003651. Endouclease3_FeS-loop_motif.
IPR003265. HhH-GPD_domain.
IPR000445. HhH_motif.
IPR023170. HTH_base_excis_C.
IPR005759. Nth.
[Graphical view ]
Pfami PF00633. HHH. 1 hit.
PF00730. HhH-GPD. 1 hit.
[Graphical view ]
PIRSFi PIRSF001435. Nth. 1 hit.
SMARTi SM00478. ENDO3c. 1 hit.
SM00525. FES. 1 hit.
[Graphical view ]
SUPFAMi SSF48150. SSF48150. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43885 / DSM 4810 / NCIB 9860Imported.

Entry informationi

Entry nameiC7MGG4_BRAFD
AccessioniPrimary (citable) accession number: C7MGG4
Entry historyi
Integrated into UniProtKB/TrEMBL: October 13, 2009
Last sequence update: October 13, 2009
Last modified: November 26, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3