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C7MGG4 (C7MGG4_BRAFD) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 31. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Endonuclease III PIRNR PIRNR001435 HAMAP-Rule MF_00942

EC=4.2.99.18 PIRNR PIRNR001435 HAMAP-Rule MF_00942
Alternative name(s):
DNA-(apurinic or apyrimidinic site) lyase HAMAP-Rule MF_00942
Gene names
Name:nth HAMAP-Rule MF_00942
Ordered Locus Names:Bfae_26220 EMBL ACU86397.1
OrganismBrachybacterium faecium (strain ATCC 43885 / DSM 4810 / NCIB 9860) [Complete proteome] [HAMAP]
Taxonomic identifier446465 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeDermabacteraceaeBrachybacterium

Protein attributes

Sequence length230 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity By similarity. PIRNR PIRNR001435

DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate By similarity. HAMAP-Rule MF_00942

Catalytic activity

The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate. PIRNR PIRNR001435 HAMAP-Rule MF_00942

Cofactor

Binds 1 4Fe-4S cluster By similarity. PIRNR PIRNR001435 HAMAP-Rule MF_00942

Sequence similarities

Belongs to the Nth/MutY family. PIRNR PIRNR001435 HAMAP-Rule MF_00942

Contains 1 HhH domain. HAMAP-Rule MF_00942

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain113 – 14028HhH By similarity HAMAP-Rule MF_00942

Sites

Metal binding2081Iron-sulfur (4Fe-4S) By similarity HAMAP-Rule MF_00942
Metal binding2151Iron-sulfur (4Fe-4S) By similarity HAMAP-Rule MF_00942
Metal binding2181Iron-sulfur (4Fe-4S) By similarity HAMAP-Rule MF_00942
Metal binding2241Iron-sulfur (4Fe-4S) By similarity HAMAP-Rule MF_00942

Sequences

Sequence LengthMass (Da)Tools
C7MGG4 [UniParc].

Last modified October 13, 2009. Version 1.
Checksum: 53F7EF229EEEBEE0

FASTA23024,427
        10         20         30         40         50         60 
MSMSTPRSTD LPRPAGPADA SRVASRLAAL HAEARTELDH RDAFELLVAT VLSAQTTDVR 

        70         80         90        100        110        120 
VNQVTPELFS RWPDPAALAA ADEGAVTEVV RPLGMGATRA RRLIGLAQGL LARHGGEVPD 

       130        140        150        160        170        180 
DQAALEALPG VGRKTAHVVR GAWFGHSLLA VDTHVGRLAQ RLGWTTATTP RRVEEDVVAR 

       190        200        210        220        230 
VEADGTGAPE EDLTILGLRL ILHGRRVCTA RAPRCGQCAL VDLCPREGVA 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001643 Genomic DNA. Translation: ACU86397.1.
RefSeqYP_003155987.1. NC_013172.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING446465.Bfae_26220.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACU86397; ACU86397; Bfae_26220.
GeneID8401167.
KEGGbfa:Bfae_26220.
PATRIC21176923. VBIBraFae133938_2585.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0177.
HOGENOMHOG000252208.
KOK10773.
OMANNKSKHL.
OrthoDBEOG6H4KC5.

Enzyme and pathway databases

BioCycBFAE446465:GH3P-2617-MONOMER.

Family and domain databases

Gene3D1.10.1670.10. 1 hit.
1.10.340.30. 1 hit.
HAMAPMF_00942. Nth.
InterProIPR011257. DNA_glycosylase.
IPR003651. Endouclease3_FeS-loop_motif.
IPR003265. HhH-GPD_domain.
IPR000445. HhH_motif.
IPR023170. HTH_base_excis_C.
IPR005759. Nth.
[Graphical view]
PfamPF00633. HHH. 1 hit.
PF00730. HhH-GPD. 1 hit.
[Graphical view]
PIRSFPIRSF001435. Nth. 1 hit.
SMARTSM00478. ENDO3c. 1 hit.
SM00525. FES. 1 hit.
[Graphical view]
SUPFAMSSF48150. SSF48150. 1 hit.
ProtoNetSearch...

Entry information

Entry nameC7MGG4_BRAFD
AccessionPrimary (citable) accession number: C7MGG4
Entry history
Integrated into UniProtKB/TrEMBL: October 13, 2009
Last sequence update: October 13, 2009
Last modified: April 16, 2014
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)