C7MG29 (C7MG29_BRAFD) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Methionine synthase (B12-independent) EMBL ACU84147.1
EC=2.1.1.14 EMBL ACU84147.1

Gene names

Ordered Locus Names:

Bfae_02700

Organism

Brachybacterium faecium (strain ATCC 43885 / DSM 4810 / NCIB 9860) [Complete proteome] [HAMAP]

Taxonomic identifier

446465 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Dermabacteraceae › Brachybacterium

Protein attributes

Sequence length	777 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation By similarity. SAAS SAAS013215
Catalytic activity	5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = tetrahydropteroyltri-L-glutamate + L-methionine. SAAS SAAS013215
Pathway	Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetE route): step 1/1. SAAS SAAS013215

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Methionine biosynthesis SAAS SAAS013215
Ligand	Metal-binding SAAS SAAS013215 Zinc SAAS SAAS013215
Molecular function	Methyltransferase SAAS SAAS013215 EMBL ACU84147.1 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	methionine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	C7MG29 [UniParc]. Last modified October 13, 2009. Version 1. Checksum: 1A5FF50EA27D3E02	FASTA	777	83,581
	10 20 30 40 50 60 MTTQTTPLPA ATPVGYPRIG PDRELKKAEE AYWAGRIDHA EFARRTRELR RATRGRLAAL 70 80 90 100 110 120 GLSAAAAAPE SFSLYDQVLD AALAVGIVPD RFASVLDADG AVDDDGLFAL ARGTAEKSPL 130 140 150 160 170 180 EMTKWFDTNY HYLVPEIGPE TELHLASTRA VELFTESLED GAGTRPVLVG PLTLLLLAKA 190 200 210 220 230 240 QDGAPEGFDP LDRLDDVVEV YAQLLARFAA AGAPWVQLDE PALAADQRVS ATELAELLQR 250 260 270 280 290 300 SLGRLAAGTD RPQLLVTTPY GGIGDLLPAL LATGADAVHL DLTRGELPTV EQLAGVDTVQ 310 320 330 340 350 360 LVAGLVEGRS VWRTELPTAA ARLAELRRRV TAAGGAPEEV AVSTSVSLQH VPHTLEAETS 370 380 390 400 410 420 LPAELTATLA FADEKITELV TLAGDEVAPG SVDGPRSVPR TFEGVSVPAV RERAAAVTAA 430 440 450 460 470 480 DAERADYTVR AEAQRRALGL PDLPTTTIGS FPQIPEVRRA RAAHRRGTLD DAGYEKAMKD 490 500 510 520 530 540 EIARVISLQE ELGLDVLVHG EPERNDMVQY FAEHLEGFAT TEHGWVQSYG SRCTRPSILF 550 560 570 580 590 600 GDVHRPAPIT VDWATYAQSL TPHPVKGMLT GPVTILAWSF VRDDQPLGDT AAQVGLALRD 610 620 630 640 650 660 EVRDLEAAGI RIVQVDEPAL RELLPLRQAA HEDYLDWSVR SFRLATSGVQ DATQIHTHLC 670 680 690 700 710 720 YSEFNVVVGA IDALDADVTS IESARSRGEI LEAVDPDSFP RGIGPGVWDI HSPRVPGAEE 730 740 750 760 770 ITEQLRRARA VVGPERLWVN PDCGLKTRGY AETEASLRHL VQAAREVRAE AGAPAAV

References

[1]

"Complete genome sequence of Brachybacterium faecium type strain (Schefferle 6-10)." Lapidus A., Pukall R., Labuttii K., Copeland A., Del Rio T.G., Nolan M., Chen F., Lucas S., Tice H., Cheng J.F., Bruce D., Goodwin L., Pitluck S., Rohde M., Goker M., Pati A., Ivanova N., Mavrommatis K. , Chen A., Palaniappan K., D'haeseleer P., Chain P., Bristow J., Eisen J.A., Markowitz V., Hugenholtz P., Kyrpides N.C., Klenk H.P. Stand. Genomic Sci. 1:3-11(2009) [PubMed: 21304631] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43885 / DSM 4810 / NCIB 9860.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001643 Genomic DNA. Translation: ACU84147.1.
RefSeq	YP_003153737.1. NC_013172.1.
3D structure databases
ProteinModelPortal	C7MG29.
ModBase	Search...
Protein-protein interaction databases
STRING	C7MG29.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	8398818.
GenomeReviews	Gene locus Bfae_02700 in contig CP001643_GR.
KEGG	bfa:Bfae_02700.
PATRIC	21172189. VBIBraFae133938_0268.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	RNIWRAN.
ProtClustDB	PRK05222.
Family and domain databases
InterPro	IPR013215. Cbl-indep_Met_Synth_N. IPR002629. Methionine_synth. [Graphical view]
KO	K00549.
Pfam	PF08267. Meth_synt_1. 1 hit. PF01717. Meth_synt_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

C7MG29_BRAFD

Accession

Primary (citable) accession number: C7MG29

Entry history

Integrated into UniProtKB/TrEMBL:	October 13, 2009
Last sequence update:	October 13, 2009
Last modified:	December 14, 2011
This is version 15 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)