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C7MEJ9

- C7MEJ9_BRAFD

UniProt

C7MEJ9 - C7MEJ9_BRAFD

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Protein
Submitted name: Isocitrate dehydrogenase, NADP-dependent, monomeric type
Gene
Bfae_22050
Organism
Brachybacterium faecium (strain ATCC 43885 / DSM 4810 / NCIB 9860)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein predictedi

Functioni

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei143 – 1431Substrate By similarityUniRule annotation
Sitei253 – 2531Critical for catalysis By similarityUniRule annotation
Metal bindingi348 – 3481Magnesium or manganese By similarityUniRule annotation
Sitei418 – 4181Critical for catalysis By similarityUniRule annotation
Binding sitei549 – 5491Substrate By similarityUniRule annotation
Metal bindingi550 – 5501Magnesium or manganese By similarityUniRule annotation
Metal bindingi554 – 5541Magnesium or manganese By similarityUniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseImported

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciBFAE446465:GH3P-2200-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Isocitrate dehydrogenase, NADP-dependent, monomeric typeImported (EC:1.1.1.42Imported)
Gene namesi
Ordered Locus Names:Bfae_22050Imported
OrganismiBrachybacterium faecium (strain ATCC 43885 / DSM 4810 / NCIB 9860)Imported
Taxonomic identifieri446465 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeDermabacteraceaeBrachybacterium
ProteomesiUP000001919: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi446465.Bfae_22050.

Structurei

3D structure databases

ProteinModelPortaliC7MEJ9.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni130 – 1378Substrate binding By similarityUniRule annotation

Phylogenomic databases

eggNOGiCOG2838.
HOGENOMiHOG000240860.
KOiK00031.
OMAiEEQRIGD.
OrthoDBiEOG6DVJPP.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

Sequencei

Sequence statusi: Complete.

C7MEJ9-1 [UniParc]FASTAAdd to Basket

« Hide

MARIIYTHTD EAPMLATASF LPILDAFSDT AGIEVTTRDI SLAGRIVAAF    50
SELLPEDQRE ADALAELGEL AKTPEANIIK LPNISASVPQ LKAAVAELQG 100
QGIALPDYPE SPSTEEEKDI RARYNSVMGS AVNPVLREGN SDRRAPSAVK 150
NFAKKHPHRM GEWAKESKTS VVTMGENDFA SNEQSVISEG EDTFSIVHVA 200
SDGTETVLKP SLPILAGEVV DSTVMRAAAL DEFLAAQIAA AKEQGVLFSL 250
HLKATMMKVS DPILFGHAVR AFFPTLFSQY GEQLAAAGLS PDNGLGGILA 300
GIDELDASVR DGVRAAIDED LAAGPDLAMV NSHKGITNLH VPSDVIIDAS 350
MPAMIRGGGK MWNKDDAEQD TLAVIPDSSY AGVYAATVED CQAHGAFDPT 400
TMGTVPNVGL MAQKAEEYGS HDKTFKIEAD GRVEVRDGSG TAVMSHEVSA 450
GDIFRACQAK DAPIRDWVQL AVRRSRESGM PAVFWLDESR AHDRNLITKV 500
NAYLAQPIDG KDTGDLDIRI LDPLEATKHT LARVRRGEDT ISVTGNVLRD 550
YLTDLFPILE LGTSAKMLSV VPLMNGGGLF ETGAGGSAPK HVQQLVEEDY 600
LRWDSLGEFL ALAESLRHLA RTAENERARV LADALDRATE TLLNEGKSPQ 650
RKLGSIDNRG SHFYLALYWA QELAAQSEDT ELATAFAPIA KELTDGEQTI 700
AEELLAVQGK PADIGGYYRP DLDKTGAVMR PSATFNRILE EISAAL 746
Length:746
Mass (Da):80,213
Last modified:October 13, 2009 - v1
Checksum:i25BCD3309E9F8372
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001643 Genomic DNA. Translation: ACU86006.1.
RefSeqiYP_003155596.1. NC_013172.1.

Genome annotation databases

EnsemblBacteriaiACU86006; ACU86006; Bfae_22050.
GeneIDi8400751.
KEGGibfa:Bfae_22050.
PATRICi21176105. VBIBraFae133938_2184.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001643 Genomic DNA. Translation: ACU86006.1 .
RefSeqi YP_003155596.1. NC_013172.1.

3D structure databases

ProteinModelPortali C7MEJ9.
ModBasei Search...

Protein-protein interaction databases

STRINGi 446465.Bfae_22050.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACU86006 ; ACU86006 ; Bfae_22050 .
GeneIDi 8400751.
KEGGi bfa:Bfae_22050.
PATRICi 21176105. VBIBraFae133938_2184.

Phylogenomic databases

eggNOGi COG2838.
HOGENOMi HOG000240860.
KOi K00031.
OMAi EEQRIGD.
OrthoDBi EOG6DVJPP.

Enzyme and pathway databases

BioCyci BFAE446465:GH3P-2200-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 3 hits.
InterProi IPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
Pfami PF03971. IDH. 1 hit.
[Graphical view ]
PIRSFi PIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsi TIGR00178. monomer_idh. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43885 / DSM 4810 / NCIB 9860.

Entry informationi

Entry nameiC7MEJ9_BRAFD
AccessioniPrimary (citable) accession number: C7MEJ9
Entry historyi
Integrated into UniProtKB/TrEMBL: October 13, 2009
Last sequence update: October 13, 2009
Last modified: July 9, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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