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C7MEJ9

- C7MEJ9_BRAFD

UniProt

C7MEJ9 - C7MEJ9_BRAFD

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Protein
Submitted name:

Isocitrate dehydrogenase, NADP-dependent, monomeric type

Gene

Bfae_22050

Organism
Brachybacterium faecium (strain ATCC 43885 / DSM 4810 / NCIB 9860)
Status
Unreviewed - Annotation score: 1 out of 5- Protein predictedi

Functioni

Cofactori

Note: Binds 1 magnesium or manganese ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei143 – 1431SubstrateUniRule annotation
Sitei253 – 2531Critical for catalysisUniRule annotation
Sitei418 – 4181Critical for catalysisUniRule annotation
Binding sitei549 – 5491SubstrateUniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseImported

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciBFAE446465:GH3P-2200-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Isocitrate dehydrogenase, NADP-dependent, monomeric typeImported (EC:1.1.1.42Imported)
Gene namesi
Ordered Locus Names:Bfae_22050Imported
OrganismiBrachybacterium faecium (strain ATCC 43885 / DSM 4810 / NCIB 9860)Imported
Taxonomic identifieri446465 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeDermabacteraceaeBrachybacterium
ProteomesiUP000001919: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi446465.Bfae_22050.

Structurei

3D structure databases

ProteinModelPortaliC7MEJ9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni130 – 1378Substrate bindingUniRule annotation

Phylogenomic databases

eggNOGiCOG2838.
HOGENOMiHOG000240860.
KOiK00031.
OMAiEEQRIGD.
OrthoDBiEOG6DVJPP.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

Sequencei

Sequence statusi: Complete.

C7MEJ9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MARIIYTHTD EAPMLATASF LPILDAFSDT AGIEVTTRDI SLAGRIVAAF
60 70 80 90 100
SELLPEDQRE ADALAELGEL AKTPEANIIK LPNISASVPQ LKAAVAELQG
110 120 130 140 150
QGIALPDYPE SPSTEEEKDI RARYNSVMGS AVNPVLREGN SDRRAPSAVK
160 170 180 190 200
NFAKKHPHRM GEWAKESKTS VVTMGENDFA SNEQSVISEG EDTFSIVHVA
210 220 230 240 250
SDGTETVLKP SLPILAGEVV DSTVMRAAAL DEFLAAQIAA AKEQGVLFSL
260 270 280 290 300
HLKATMMKVS DPILFGHAVR AFFPTLFSQY GEQLAAAGLS PDNGLGGILA
310 320 330 340 350
GIDELDASVR DGVRAAIDED LAAGPDLAMV NSHKGITNLH VPSDVIIDAS
360 370 380 390 400
MPAMIRGGGK MWNKDDAEQD TLAVIPDSSY AGVYAATVED CQAHGAFDPT
410 420 430 440 450
TMGTVPNVGL MAQKAEEYGS HDKTFKIEAD GRVEVRDGSG TAVMSHEVSA
460 470 480 490 500
GDIFRACQAK DAPIRDWVQL AVRRSRESGM PAVFWLDESR AHDRNLITKV
510 520 530 540 550
NAYLAQPIDG KDTGDLDIRI LDPLEATKHT LARVRRGEDT ISVTGNVLRD
560 570 580 590 600
YLTDLFPILE LGTSAKMLSV VPLMNGGGLF ETGAGGSAPK HVQQLVEEDY
610 620 630 640 650
LRWDSLGEFL ALAESLRHLA RTAENERARV LADALDRATE TLLNEGKSPQ
660 670 680 690 700
RKLGSIDNRG SHFYLALYWA QELAAQSEDT ELATAFAPIA KELTDGEQTI
710 720 730 740
AEELLAVQGK PADIGGYYRP DLDKTGAVMR PSATFNRILE EISAAL
Length:746
Mass (Da):80,213
Last modified:October 13, 2009 - v1
Checksum:i25BCD3309E9F8372
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001643 Genomic DNA. Translation: ACU86006.1.
RefSeqiYP_003155596.1. NC_013172.1.

Genome annotation databases

EnsemblBacteriaiACU86006; ACU86006; Bfae_22050.
GeneIDi8400751.
KEGGibfa:Bfae_22050.
PATRICi21176105. VBIBraFae133938_2184.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001643 Genomic DNA. Translation: ACU86006.1 .
RefSeqi YP_003155596.1. NC_013172.1.

3D structure databases

ProteinModelPortali C7MEJ9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 446465.Bfae_22050.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACU86006 ; ACU86006 ; Bfae_22050 .
GeneIDi 8400751.
KEGGi bfa:Bfae_22050.
PATRICi 21176105. VBIBraFae133938_2184.

Phylogenomic databases

eggNOGi COG2838.
HOGENOMi HOG000240860.
KOi K00031.
OMAi EEQRIGD.
OrthoDBi EOG6DVJPP.

Enzyme and pathway databases

BioCyci BFAE446465:GH3P-2200-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 3 hits.
InterProi IPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
Pfami PF03971. IDH. 1 hit.
[Graphical view ]
PIRSFi PIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsi TIGR00178. monomer_idh. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43885 / DSM 4810 / NCIB 9860Imported.

Entry informationi

Entry nameiC7MEJ9_BRAFD
AccessioniPrimary (citable) accession number: C7MEJ9
Entry historyi
Integrated into UniProtKB/TrEMBL: October 13, 2009
Last sequence update: October 13, 2009
Last modified: November 26, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3