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C7MEJ9

- C7MEJ9_BRAFD

UniProt

C7MEJ9 - C7MEJ9_BRAFD

Protein
Submitted name:

Isocitrate dehydrogenase, NADP-dependent, monomeric type

Gene

Bfae_22050

Organism
Brachybacterium faecium (strain ATCC 43885 / DSM 4810 / NCIB 9860)
Status
Unreviewed - Annotation score: 1 out of 5- Protein predictedi
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    • History
      Entry version 39 (01 Oct 2014)
      Sequence version 1 (13 Oct 2009)
      Previous versions | rss
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    Functioni

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei143 – 1431SubstrateUniRule annotation
    Sitei253 – 2531Critical for catalysisUniRule annotation
    Metal bindingi348 – 3481Magnesium or manganese
    Sitei418 – 4181Critical for catalysisUniRule annotation
    Binding sitei549 – 5491SubstrateUniRule annotation
    Metal bindingi550 – 5501Magnesium or manganese
    Metal bindingi554 – 5541Magnesium or manganese

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. tricarboxylic acid cycle Source: InterPro

    Keywords - Molecular functioni

    OxidoreductaseImported

    Keywords - Ligandi

    MagnesiumUniRule annotation, Metal-bindingUniRule annotation

    Enzyme and pathway databases

    BioCyciBFAE446465:GH3P-2200-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Isocitrate dehydrogenase, NADP-dependent, monomeric typeImported (EC:1.1.1.42Imported)
    Gene namesi
    Ordered Locus Names:Bfae_22050Imported
    OrganismiBrachybacterium faecium (strain ATCC 43885 / DSM 4810 / NCIB 9860)Imported
    Taxonomic identifieri446465 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeDermabacteraceaeBrachybacterium
    ProteomesiUP000001919: Chromosome

    Interactioni

    Protein-protein interaction databases

    STRINGi446465.Bfae_22050.

    Structurei

    3D structure databases

    ProteinModelPortaliC7MEJ9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni130 – 1378Substrate bindingUniRule annotation

    Phylogenomic databases

    eggNOGiCOG2838.
    HOGENOMiHOG000240860.
    KOiK00031.
    OMAiEEQRIGD.
    OrthoDBiEOG6DVJPP.

    Family and domain databases

    Gene3Di3.40.718.10. 3 hits.
    InterProiIPR004436. Isocitrate_DH_NADP_mono.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PfamiPF03971. IDH. 1 hit.
    [Graphical view]
    PIRSFiPIRSF009407. IDH_monmr. 1 hit.
    TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    C7MEJ9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MARIIYTHTD EAPMLATASF LPILDAFSDT AGIEVTTRDI SLAGRIVAAF    50
    SELLPEDQRE ADALAELGEL AKTPEANIIK LPNISASVPQ LKAAVAELQG 100
    QGIALPDYPE SPSTEEEKDI RARYNSVMGS AVNPVLREGN SDRRAPSAVK 150
    NFAKKHPHRM GEWAKESKTS VVTMGENDFA SNEQSVISEG EDTFSIVHVA 200
    SDGTETVLKP SLPILAGEVV DSTVMRAAAL DEFLAAQIAA AKEQGVLFSL 250
    HLKATMMKVS DPILFGHAVR AFFPTLFSQY GEQLAAAGLS PDNGLGGILA 300
    GIDELDASVR DGVRAAIDED LAAGPDLAMV NSHKGITNLH VPSDVIIDAS 350
    MPAMIRGGGK MWNKDDAEQD TLAVIPDSSY AGVYAATVED CQAHGAFDPT 400
    TMGTVPNVGL MAQKAEEYGS HDKTFKIEAD GRVEVRDGSG TAVMSHEVSA 450
    GDIFRACQAK DAPIRDWVQL AVRRSRESGM PAVFWLDESR AHDRNLITKV 500
    NAYLAQPIDG KDTGDLDIRI LDPLEATKHT LARVRRGEDT ISVTGNVLRD 550
    YLTDLFPILE LGTSAKMLSV VPLMNGGGLF ETGAGGSAPK HVQQLVEEDY 600
    LRWDSLGEFL ALAESLRHLA RTAENERARV LADALDRATE TLLNEGKSPQ 650
    RKLGSIDNRG SHFYLALYWA QELAAQSEDT ELATAFAPIA KELTDGEQTI 700
    AEELLAVQGK PADIGGYYRP DLDKTGAVMR PSATFNRILE EISAAL 746
    Length:746
    Mass (Da):80,213
    Last modified:October 13, 2009 - v1
    Checksum:i25BCD3309E9F8372
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001643 Genomic DNA. Translation: ACU86006.1.
    RefSeqiYP_003155596.1. NC_013172.1.

    Genome annotation databases

    EnsemblBacteriaiACU86006; ACU86006; Bfae_22050.
    GeneIDi8400751.
    KEGGibfa:Bfae_22050.
    PATRICi21176105. VBIBraFae133938_2184.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001643 Genomic DNA. Translation: ACU86006.1 .
    RefSeqi YP_003155596.1. NC_013172.1.

    3D structure databases

    ProteinModelPortali C7MEJ9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 446465.Bfae_22050.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACU86006 ; ACU86006 ; Bfae_22050 .
    GeneIDi 8400751.
    KEGGi bfa:Bfae_22050.
    PATRICi 21176105. VBIBraFae133938_2184.

    Phylogenomic databases

    eggNOGi COG2838.
    HOGENOMi HOG000240860.
    KOi K00031.
    OMAi EEQRIGD.
    OrthoDBi EOG6DVJPP.

    Enzyme and pathway databases

    BioCyci BFAE446465:GH3P-2200-MONOMER.

    Family and domain databases

    Gene3Di 3.40.718.10. 3 hits.
    InterProi IPR004436. Isocitrate_DH_NADP_mono.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    Pfami PF03971. IDH. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF009407. IDH_monmr. 1 hit.
    TIGRFAMsi TIGR00178. monomer_idh. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 43885 / DSM 4810 / NCIB 9860Imported.

    Entry informationi

    Entry nameiC7MEJ9_BRAFD
    AccessioniPrimary (citable) accession number: C7MEJ9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 13, 2009
    Last sequence update: October 13, 2009
    Last modified: October 1, 2014
    This is version 39 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3