ID   C7M9Z0_BRAFD            Unreviewed;       408 AA.
AC   C7M9Z0;
DT   13-OCT-2009, integrated into UniProtKB/TrEMBL.
DT   13-OCT-2009, sequence version 1.
DT   27-MAR-2024, entry version 71.
DE   RecName: Full=exo-alpha-sialidase {ECO:0000256|ARBA:ARBA00012733};
DE            EC=3.2.1.18 {ECO:0000256|ARBA:ARBA00012733};
GN   OrderedLocusNames=Bfae_08300 {ECO:0000313|EMBL:ACU84684.1};
OS   Brachybacterium faecium (strain ATCC 43885 / DSM 4810 / JCM 11609 / LMG
OS   19847 / NBRC 14762 / NCIMB 9860 / 6-10).
OC   Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Dermabacteraceae;
OC   Brachybacterium.
OX   NCBI_TaxID=446465 {ECO:0000313|EMBL:ACU84684.1, ECO:0000313|Proteomes:UP000001919};
RN   [1] {ECO:0000313|EMBL:ACU84684.1, ECO:0000313|Proteomes:UP000001919}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43885 / DSM 4810 / JCM 11609 / LMG 19847 / NBRC 14762 /
RC   NCIMB 9860 / 6-10 {ECO:0000313|Proteomes:UP000001919};
RX   PubMed=21304631; DOI=10.4056/sigs.492;
RA   Lapidus A., Pukall R., Labuttii K., Copeland A., Del Rio T.G., Nolan M.,
RA   Chen F., Lucas S., Tice H., Cheng J.F., Bruce D., Goodwin L., Pitluck S.,
RA   Rohde M., Goker M., Pati A., Ivanova N., Mavrommatis K., Chen A.,
RA   Palaniappan K., D'haeseleer P., Chain P., Bristow J., Eisen J.A.,
RA   Markowitz V., Hugenholtz P., Kyrpides N.C., Klenk H.P.;
RT   "Complete genome sequence of Brachybacterium faecium type strain
RT   (Schefferle 6-10).";
RL   Stand. Genomic Sci. 1:3-11(2009).
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DR   EMBL; CP001643; ACU84684.1; -; Genomic_DNA.
DR   RefSeq; WP_012804458.1; NC_013172.1.
DR   RefSeq; YP_003154274.1; NC_013172.1.
DR   AlphaFoldDB; C7M9Z0; -.
DR   STRING; 446465.Bfae_08300; -.
DR   CAZy; GH33; Glycoside Hydrolase Family 33.
DR   KEGG; bfa:Bfae_08300; -.
DR   PATRIC; fig|446465.5.peg.822; -.
DR   eggNOG; COG4409; Bacteria.
DR   HOGENOM; CLU_024620_1_1_11; -.
DR   OrthoDB; 7294637at2; -.
DR   Proteomes; UP000001919; Chromosome.
DR   GO; GO:0004308; F:exo-alpha-sialidase activity; IEA:InterPro.
DR   CDD; cd15482; Sialidase_non-viral; 1.
DR   Gene3D; 2.120.10.10; -; 1.
DR   InterPro; IPR011040; Sialidase.
DR   InterPro; IPR026856; Sialidase_fam.
DR   InterPro; IPR036278; Sialidase_sf.
DR   InterPro; IPR006311; TAT_signal.
DR   PANTHER; PTHR10628; SIALIDASE; 1.
DR   PANTHER; PTHR10628:SF25; SIALIDASE-1; 1.
DR   Pfam; PF13088; BNR_2; 1.
DR   SUPFAM; SSF50939; Sialidases; 1.
DR   PROSITE; PS51318; TAT; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000001919};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..27
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           28..408
FT                   /note="exo-alpha-sialidase"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5002979247"
FT   DOMAIN          94..377
FT                   /note="Sialidase"
FT                   /evidence="ECO:0000259|Pfam:PF13088"
FT   REGION          88..107
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   408 AA;  44657 MW;  6FF2251115DD5ECE CRC64;
     MEPSLTRRGL LGTAAALTAA GAGAVAAASP AAALPPIKDN GRRQGSYEEQ VLAAPGDWGV
     PNFRIPALAV APNGDLLAAF DKRPVHGDSP APNSIWQRRS RDGGRTWEEP TVVRAGLESE
     EPGEKLGYSD PSYVVDTETG TLFLFCVFSK DTGVWDSEYG NDDADRRIQS ANLSVSHDSG
     ETWEHRSLTE VVKPEDCRAM FATSGAGIQL RYGKHRGRLI QQYAGWFRGE GGEEDVSAYS
     VYSDDHGETW TMGTPVGTEM DENKVAELSD GTVMLNSREH VRTGRRWVAL SHDGGETWED
     LHRDPHLVDP GNNAHLTRAY PEAPQGSAKA QVLLFSHADH EPDDRVNGTV EISTDDGATW
     ERKRVFAPGP CQYSVLIPVA RDEFLLAYEG EDETLLIARL DMDWILSR
//