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C7M8D8 (C7M8D8_CAPOD) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 18. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase HAMAP MF_00116
Short name=dUTPase HAMAP MF_00116
EC=3.6.1.23 HAMAP MF_00116
Alternative name(s):
dUTP pyrophosphatase HAMAP MF_00116
Gene names
Name:dut HAMAP MF_00116
Ordered Locus Names:Coch_0751
OrganismCapnocytophaga ochracea (strain ATCC 27872 / DSM 7271 / JCM 12966 / VPI 2845) (Bacteroides ochraceus) [Complete proteome] [HAMAP]
Taxonomic identifier521097 [NCBI]
Taxonomic lineageBacteria › Bacteroidetes › Flavobacteriia › Flavobacteriales › Flavobacteriaceae › Capnocytophaga

Protein attributes

Sequence length145 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA By similarity. HAMAP MF_00116 SAAS SAAS008181

Catalytic activity

dUTP + H2O = dUMP + diphosphate. HAMAP MF_00116 SAAS SAAS008181

Cofactor

Magnesium By similarity. HAMAP MF_00116 SAAS SAAS008181

Pathway

Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2. HAMAP MF_00116

Sequence similarities

Belongs to the dUTPase family. HAMAP MF_00116

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region64 – 663Substrate binding By similarity HAMAP MF_00116
Region81 – 833Substrate binding By similarity HAMAP MF_00116

Sites

Binding site771Substrate By similarity HAMAP MF_00116
Binding site911Substrate; via amide nitrogen and carbonyl oxygen By similarity HAMAP MF_00116

Sequences

Sequence LengthMass (Da)Tools
C7M8D8 [UniParc].

Last modified October 13, 2009. Version 1.
Checksum: C5032C54F555B1BD

FASTA14515,681
        10         20         30         40         50         60 
MTVKIKNLSN NELPSYQTEG AAGVDLRANL PNSNITLQPL ERTLVPTGLF LEIPEGYEAQ 

        70         80         90        100        110        120 
VRPRSGMAIK HGITVINSPG TIDCDYRGEV KVPIVNLSNE PFTIAHSDRI AQMVFAKYEK 

       130        140 
ATFETVTELS QTERGAGGFG STGGN

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001632 Genomic DNA. Translation: ACU92308.1.
RefSeqYP_003140869.1. NC_013162.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGC7M8D8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID8367168.
GenomeReviewsGene locus Coch_0751 in contig CP001632_GR.
KEGGcoc:Coch_0751.
PATRIC21270250. VBICapOch61160_0738.

Organism-specific databases

CMRSearch...

Phylogenomic databases

OMALDLRACI.

Family and domain databases

HAMAPMF_00116. dUTPase_bact.
[Tree]
InterProIPR008180. dUTP_pyroPase.
IPR008181. dUTP_pyroPase_sf.
[Graphical view]
KOK01520.
PANTHERPTHR11241. PTHR11241. 1 hit.
PfamPF00692. dUTPase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00576. Dut. 1 hit.
ProtoNetSearch...

Entry information

Entry nameC7M8D8_CAPOD
AccessionPrimary (citable) accession number: C7M8D8
Entry history
Integrated into UniProtKB/TrEMBL: October 13, 2009
Last sequence update: October 13, 2009
Last modified: December 14, 2011
This is version 18 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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