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C7M816 (C7M816_CAPOD) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 18. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase HAMAP MF_00172
EC=2.1.1.14 HAMAP MF_00172
Alternative name(s):
Cobalamin-independent methionine synthase HAMAP MF_00172
Methionine synthase, vitamin-B12 independent isozyme HAMAP MF_00172
Gene names
Name:metE HAMAP MF_00172
Ordered Locus Names:Coch_1731
OrganismCapnocytophaga ochracea (strain ATCC 27872 / DSM 7271 / JCM 12966 / VPI 2845) (Bacteroides ochraceus) [Complete proteome] [HAMAP]
Taxonomic identifier521097 [NCBI]
Taxonomic lineageBacteria › Bacteroidetes › Flavobacteriia › Flavobacteriales › Flavobacteriaceae › Capnocytophaga

Protein attributes

Sequence length766 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation By similarity. HAMAP MF_00172 SAAS SAAS013215

Catalytic activity

5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = tetrahydropteroyltri-L-glutamate + L-methionine. HAMAP MF_00172 SAAS SAAS013215

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP MF_00172

Pathway

Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetE route): step 1/1. HAMAP MF_00172 SAAS SAAS013215

Sequence similarities

Belongs to the vitamin-B12 independent methionine synthase family. HAMAP MF_00172

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Metal binding6521Zinc By similarity HAMAP MF_00172
Metal binding6541Zinc By similarity HAMAP MF_00172
Metal binding7371Zinc By similarity HAMAP MF_00172

Sequences

Sequence LengthMass (Da)Tools
C7M816 [UniParc].

Last modified October 13, 2009. Version 1.
Checksum: 7E94DA6432700EA6

FASTA76687,515
        10         20         30         40         50         60 
MKSNVLGYPR IGEKRELKKA NESFWAGKIS EEELLAVAEN IRVHNWTLQK EAGVDLIPSN 

        70         80         90        100        110        120 
DFSLYDQMLD FSFTVSAIPE RFTPIKHLRD LERYYALARG YQKNGIDITA MEMTKWFDTN 

       130        140        150        160        170        180 
YHYIVPEFTK DQSFKILVNK PLQEFNLAKK HGFDTKPVLI GLVTYLLLGK EKEQGFHRLD 

       190        200        210        220        230        240 
LAERLLPVYV QIVRSLVDAG AKTIQIDEPY LALDLPEGAA DVYKKVYTEL RSKFPTTEFI 

       250        260        270        280        290        300 
LTTYFGALDN NTELAVSLPF NVLHIDLVRA AAQLDKVLKA LPADKKLSLG VVDGRNIWKN 

       310        320        330        340        350        360 
NFEHSLALIE KAKEAIGADR LLIATSCSLL HSPCNLELEN NEKVLTPEIK QWLAFAKQKV 

       370        380        390        400        410        420 
KEVTTLQALA TGHITPEVKV AFEENKKAAE TRKTSPLIHD NKVKERVNNI TAKDDVRHSP 

       430        440        450        460        470        480 
FNERKVAQHK ALNLPLFPTT TIGSFPQTDE VRSWRARFKK GELTQAEYDK LLEKEIEESI 

       490        500        510        520        530        540 
RFQEDTNIDV LVHGEFERND MVEYFGELLK GYTFTKFGWV QSYGSRCVKP PIIFGDISRP 

       550        560        570        580        590        600 
EPMTVRWSKY AQSLTKLPVK GMLTGPVTIL QWSFVRDDQP RSETCLQIAL AIRDEVVDLE 

       610        620        630        640        650        660 
KAGIKVIQID EPAIREGLPL RKSEWKAYFD WAIKAFRISA SGVKDETQIH THMCYSEFND 

       670        680        690        700        710        720 
MIEAIADMDA DVITIECSRS QMELLDVFGD FKYPNEIGPG VYDIHSPRVP SQEEMTNLMK 

       730        740        750        760 
KAISVVPKEQ LWVNPDCGLK TRHWPETKAA LHAMVDTAKE LRNLYK

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001632 Genomic DNA. Translation: ACU93276.1.
RefSeqYP_003141837.1. NC_013162.1.

3D structure databases

ProteinModelPortalC7M816.
ModBaseSearch...

Protein-protein interaction databases

STRINGC7M816.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID8368177.
GenomeReviewsGene locus Coch_1731 in contig CP001632_GR.
KEGGcoc:Coch_1731.
PATRIC21272244. VBICapOch61160_1709.

Organism-specific databases

CMRSearch...

Phylogenomic databases

OMARNIWRAN.
ProtClustDBPRK05222.

Family and domain databases

HAMAPMF_00172. Meth_synth.
[Tree]
InterProIPR013215. Cbl-indep_Met_Synth_N.
IPR006276. Cobalamin-indep_Met_synthase.
IPR002629. Methionine_synth.
[Graphical view]
KOK00549.
PfamPF08267. Meth_synt_1. 1 hit.
PF01717. Meth_synt_2. 1 hit.
[Graphical view]
PIRSFPIRSF000382. MeTrfase_B12_ind. 1 hit.
TIGRFAMsTIGR01371. Met_syn_B12ind. 1 hit.
ProtoNetSearch...

Entry information

Entry nameC7M816_CAPOD
AccessionPrimary (citable) accession number: C7M816
Entry history
Integrated into UniProtKB/TrEMBL: October 13, 2009
Last sequence update: October 13, 2009
Last modified: December 14, 2011
This is version 18 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info