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C7M311

- C7M311_ACIFD

UniProt

C7M311 - C7M311_ACIFD

Protein

Alanine racemase

Gene

Afer_0437

Organism
Acidimicrobium ferrooxidans (strain DSM 10331 / JCM 15462 / NBRC 103882 / ICP)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 1 (13 Oct 2009)
      Previous versions | rss
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    Functioni

    Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

    Catalytic activityi

    L-alanine = D-alanine.UniRule annotationSAAS annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei37 – 371Proton acceptor; specific for D-alanineUniRule annotation
    Binding sitei134 – 1341SubstrateUniRule annotation
    Active sitei256 – 2561Proton acceptor; specific for L-alanineUniRule annotation
    Binding sitei305 – 3051Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. alanine racemase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-alanine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    IsomeraseUniRule annotationSAAS annotationImported

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciAFER525909:GHMR-450-MONOMER.
    UniPathwayiUPA00042; UER00497.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
    Gene namesi
    Ordered Locus Names:Afer_0437Imported
    OrganismiAcidimicrobium ferrooxidans (strain DSM 10331 / JCM 15462 / NBRC 103882 / ICP)Imported
    Taxonomic identifieri525909 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaAcidimicrobidaeAcidimicrobialesAcidimicrobineaeAcidimicrobiaceaeAcidimicrobium
    ProteomesiUP000000771: Chromosome

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei37 – 371N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Protein-protein interaction databases

    STRINGi525909.Afer_0437.

    Structurei

    3D structure databases

    ProteinModelPortaliC7M311.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alanine racemase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0787.
    HOGENOMiHOG000031444.
    KOiK01775.
    OMAiLWQLEAI.
    OrthoDBiEOG6PP9NJ.

    Family and domain databases

    Gene3Di2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPiMF_01201. Ala_racemase.
    InterProiIPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view]
    PfamiPF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view]
    PRINTSiPR00992. ALARACEMASE.
    SMARTiSM01005. Ala_racemase_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsiTIGR00492. alr. 1 hit.
    PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C7M311-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIGHRPTEAR IDLERLRANA RLLAERAAPA ALSAVVKADA YGHGASTVAR    50
    ALGDLVDAFC VATVEEGLAL RAAGVTGRVL VLSEPPESAV SACAASSLEP 100
    FVEHERFVEA LAGAASALGR EASVHIDVDT GMHRSGVHPA QAATLAASAR 150
    RHGVRVVGVA SHLVRADEAP THPTTLEQLS RFREVAARIG APERHLLATG 200
    GLLALPEGRF ERVRVGIGLY GYGPRRDDVA GLRPVLRLVS HVVRLEALGA 250
    GEAVSYGHRR PLDVPAEVAT LPIGYADGVP RAAFDAGLAF WAKGVRLPIA 300
    GTVTMDQTMV AAPRGLLALG DEVSLIGDEV DAWEWADVLG TIPYEVLARL 350
    GPRIPRVVEH GTA 363
    Length:363
    Mass (Da):38,096
    Last modified:October 13, 2009 - v1
    Checksum:i22B3F7CBF549DA83
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001631 Genomic DNA. Translation: ACU53405.1.
    RefSeqiWP_015797906.1. NC_013124.1.
    YP_003109078.1. NC_013124.1.

    Genome annotation databases

    EnsemblBacteriaiACU53405; ACU53405; Afer_0437.
    GeneIDi8322496.
    KEGGiafo:Afer_0437.
    PATRICi20640495. VBIAciFer34262_0457.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001631 Genomic DNA. Translation: ACU53405.1 .
    RefSeqi WP_015797906.1. NC_013124.1.
    YP_003109078.1. NC_013124.1.

    3D structure databases

    ProteinModelPortali C7M311.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 525909.Afer_0437.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACU53405 ; ACU53405 ; Afer_0437 .
    GeneIDi 8322496.
    KEGGi afo:Afer_0437.
    PATRICi 20640495. VBIAciFer34262_0457.

    Phylogenomic databases

    eggNOGi COG0787.
    HOGENOMi HOG000031444.
    KOi K01775.
    OMAi LWQLEAI.
    OrthoDBi EOG6PP9NJ.

    Enzyme and pathway databases

    UniPathwayi UPA00042 ; UER00497 .
    BioCyci AFER525909:GHMR-450-MONOMER.

    Family and domain databases

    Gene3Di 2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPi MF_01201. Ala_racemase.
    InterProi IPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view ]
    Pfami PF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00992. ALARACEMASE.
    SMARTi SM01005. Ala_racemase_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsi TIGR00492. alr. 1 hit.
    PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 10331 / JCM 15462 / NBRC 103882 / ICPImported.

    Entry informationi

    Entry nameiC7M311_ACIFD
    AccessioniPrimary (citable) accession number: C7M311
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 13, 2009
    Last sequence update: October 13, 2009
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3