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C7M311

- C7M311_ACIFD

UniProt

C7M311 - C7M311_ACIFD

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Protein
Alanine racemase
Gene
Afer_0437
Organism
Acidimicrobium ferrooxidans (strain DSM 10331 / JCM 15462 / NBRC 103882 / ICP)
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids By similarity.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotations

Cofactori

Pyridoxal phosphate By similarity.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei37 – 371Proton acceptor; specific for D-alanine By similarityUniRule annotation
Binding sitei134 – 1341Substrate By similarityUniRule annotation
Active sitei256 – 2561Proton acceptor; specific for L-alanine By similarityUniRule annotation
Binding sitei305 – 3051Substrate; via amide nitrogen By similarityUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotationsImported

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciAFER525909:GHMR-450-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:Afer_0437Imported
OrganismiAcidimicrobium ferrooxidans (strain DSM 10331 / JCM 15462 / NBRC 103882 / ICP)Imported
Taxonomic identifieri525909 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaAcidimicrobidaeAcidimicrobialesAcidimicrobineaeAcidimicrobiaceaeAcidimicrobium
ProteomesiUP000000771: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei37 – 371N6-(pyridoxal phosphate)lysine By similarityUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi525909.Afer_0437.

Structurei

3D structure databases

ProteinModelPortaliC7M311.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0787.
HOGENOMiHOG000031444.
KOiK01775.
OMAiLWQLEAI.
OrthoDBiEOG6PP9NJ.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C7M311-1 [UniParc]FASTAAdd to Basket

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MIGHRPTEAR IDLERLRANA RLLAERAAPA ALSAVVKADA YGHGASTVAR    50
ALGDLVDAFC VATVEEGLAL RAAGVTGRVL VLSEPPESAV SACAASSLEP 100
FVEHERFVEA LAGAASALGR EASVHIDVDT GMHRSGVHPA QAATLAASAR 150
RHGVRVVGVA SHLVRADEAP THPTTLEQLS RFREVAARIG APERHLLATG 200
GLLALPEGRF ERVRVGIGLY GYGPRRDDVA GLRPVLRLVS HVVRLEALGA 250
GEAVSYGHRR PLDVPAEVAT LPIGYADGVP RAAFDAGLAF WAKGVRLPIA 300
GTVTMDQTMV AAPRGLLALG DEVSLIGDEV DAWEWADVLG TIPYEVLARL 350
GPRIPRVVEH GTA 363
Length:363
Mass (Da):38,096
Last modified:October 13, 2009 - v1
Checksum:i22B3F7CBF549DA83
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001631 Genomic DNA. Translation: ACU53405.1.
RefSeqiWP_015797906.1. NC_013124.1.
YP_003109078.1. NC_013124.1.

Genome annotation databases

EnsemblBacteriaiACU53405; ACU53405; Afer_0437.
GeneIDi8322496.
KEGGiafo:Afer_0437.
PATRICi20640495. VBIAciFer34262_0457.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001631 Genomic DNA. Translation: ACU53405.1 .
RefSeqi WP_015797906.1. NC_013124.1.
YP_003109078.1. NC_013124.1.

3D structure databases

ProteinModelPortali C7M311.
ModBasei Search...

Protein-protein interaction databases

STRINGi 525909.Afer_0437.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACU53405 ; ACU53405 ; Afer_0437 .
GeneIDi 8322496.
KEGGi afo:Afer_0437.
PATRICi 20640495. VBIAciFer34262_0457.

Phylogenomic databases

eggNOGi COG0787.
HOGENOMi HOG000031444.
KOi K01775.
OMAi LWQLEAI.
OrthoDBi EOG6PP9NJ.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .
BioCyci AFER525909:GHMR-450-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR00492. alr. 1 hit.
PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 10331 / JCM 15462 / NBRC 103882 / ICP.

Entry informationi

Entry nameiC7M311_ACIFD
AccessioniPrimary (citable) accession number: C7M311
Entry historyi
Integrated into UniProtKB/TrEMBL: October 13, 2009
Last sequence update: October 13, 2009
Last modified: September 3, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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