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C7LYC2 (C7LYC2_ACIFD) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 22. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Gamma-glutamyl phosphate reductase HAMAP MF_00412
Short name=GPR HAMAP MF_00412
EC=1.2.1.41 HAMAP MF_00412
Alternative name(s):
Glutamate-5-semialdehyde dehydrogenase HAMAP MF_00412
Glutamyl-gamma-semialdehyde dehydrogenase HAMAP MF_00412
Gene names
Name:proA HAMAP MF_00412
Ordered Locus Names:Afer_0782
OrganismAcidimicrobium ferrooxidans (strain DSM 10331 / JCM 15462 / NBRC 103882 / ICP) [Complete proteome] [HAMAP]
Taxonomic identifier525909 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Acidimicrobidae › Acidimicrobiales › Acidimicrobineae › Acidimicrobiaceae › Acidimicrobium

Protein attributes

Sequence length425 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the NADPH dependent reduction of L-gamma-glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate By similarity. HAMAP MF_00412 SAAS SAAS020593

Catalytic activity

L-glutamate 5-semialdehyde + phosphate + NADP+ = L-glutamyl 5-phosphate + NADPH. HAMAP MF_00412 SAAS SAAS020593

Pathway

Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2. HAMAP MF_00412 SAAS SAAS020593

Subcellular location

Cytoplasm By similarity HAMAP MF_00412 SAAS SAAS020593.

Sequence similarities

Belongs to the gamma-glutamyl phosphate reductase family. HAMAP MF_00412

Sequences

Sequence LengthMass (Da)Tools
C7LYC2 [UniParc].

Last modified October 13, 2009. Version 1.
Checksum: 272AB0F86F259E7F

FASTA42544,889
        10         20         30         40         50         60 
MIQSVEQAQV DRVDARAIEA VAVAARAAQP QLAAAPGEQR RAALLAAARE LRASRAAILE 

        70         80         90        100        110        120 
ANERDVADAV DLTSAQRDRL RLDDARIEQM AQGVEAVAAQ PDVVGRVVDG WTLPNGLRVR 

       130        140        150        160        170        180 
RVRVPLGVVG VIYENRPNVT ADAAALALAS GNAIVLRGSS QALASNRVIR GAIARGVASV 

       190        200        210        220        230        240 
GLPEALVGLV EDTSREGARA FMRLEGIIDV LVPRGGPGLL RAVRDEARVP VIIDGDGNCH 

       250        260        270        280        290        300 
VYVDRAADLA KAAAIVENAK LQRPGVCNAA ETLLVHAAVA DEFLPQLAER LGSCELRGDE 

       310        320        330        340        350        360 
RTRALVPRAL PATAADWETE YLAPILAVRV VDTLEDAIAH IRRYSSGHSE AIVTEDLAAA 

       370        380        390        400        410        420 
TRFTGEVDAA AVLVNASTRF VDGGQLGFGA EIGISTQKLH WRGPMGTEAL TSVKLVIWGD 


GHVRT

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001631 Genomic DNA. Translation: ACU53730.1.
RefSeqYP_003109403.1. NC_013124.1.

3D structure databases

ProteinModelPortalC7LYC2.
ModBaseSearch...

Protein-protein interaction databases

STRINGC7LYC2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID8322844.
GenomeReviewsGene locus Afer_0782 in contig CP001631_GR.
KEGGafo:Afer_0782.
PATRIC20641227. VBIAciFer34262_0820.

Organism-specific databases

CMRSearch...

Phylogenomic databases

OMAQYPAACN.

Family and domain databases

HAMAPMF_00412. ProA.
[Tree]
InterProIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR000965. G-glutamylP_reductase.
IPR020593. G-glutamylP_reductase_CS.
IPR012134. Glu-5-SA_DH.
[Graphical view]
Gene3DG3DSA:3.40.309.10. Aldehyde_dehydrogenase_C. 1 hit.
G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 2 hits.
KOK00147.
PANTHERPTHR11063:SF1. GSA_DH. 1 hit.
PfamPF00171. Aldedh. 2 hits.
[Graphical view]
PIRSFPIRSF000151. GPR. 1 hit.
SUPFAMSSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
TIGRFAMsTIGR00407. ProA. 1 hit.
PROSITEPS01223. PROA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameC7LYC2_ACIFD
AccessionPrimary (citable) accession number: C7LYC2
Entry history
Integrated into UniProtKB/TrEMBL: October 13, 2009
Last sequence update: October 13, 2009
Last modified: December 14, 2011
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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