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Protein

Chromosomal replication initiator protein DnaA

Gene

Dbac_3097

Organism
Desulfomicrobium baculatum (strain DSM 4028 / VKM B-1378) (Desulfovibrio baculatus)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingUniRule annotationSAAS annotation
Biological processDNA replicationUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciDBAC525897:G1GEX-3105-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Chromosomal replication initiator protein DnaAUniRule annotation
Gene namesi
Ordered Locus Names:Dbac_3097Imported
OrganismiDesulfomicrobium baculatum (strain DSM 4028 / VKM B-1378) (Desulfovibrio baculatus)Imported
Taxonomic identifieri525897 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfovibrionalesDesulfomicrobiaceaeDesulfomicrobium
Proteomesi
  • UP000002216 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm SAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi525897.Dbac_3097

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini124 – 245AAAInterPro annotationAdd BLAST122
Domaini327 – 396Bac_DnaA_CInterPro annotationAdd BLAST70

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili396 – 416Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the DnaA family.UniRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiENOG4105CI4 Bacteria
COG0593 LUCA
HOGENOMiHOG000227577
KOiK02313
OMAiDFRYLQG
OrthoDBiPOG091H02FF

Family and domain databases

CDDicd06571 Bac_DnaA_C, 1 hit
Gene3Di1.10.1750.10, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR001957 Chromosome_initiator_DnaA
IPR020591 Chromosome_initiator_DnaA-like
IPR018312 Chromosome_initiator_DnaA_CS
IPR013317 DnaA
IPR013159 DnaA_C
IPR027417 P-loop_NTPase
IPR025662 Sigma_54_int_dom_ATP-bd_1
IPR010921 Trp_repressor/repl_initiator
PANTHERiPTHR30050:SF2 PTHR30050:SF2, 1 hit
PfamiView protein in Pfam
PF00308 Bac_DnaA, 1 hit
PF08299 Bac_DnaA_C, 1 hit
PRINTSiPR00051 DNAA
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SM00760 Bac_DnaA_C, 1 hit
SUPFAMiSSF48295 SSF48295, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS01008 DNAA, 1 hit
PS00675 SIGMA54_INTERACT_1, 1 hit

Sequencei

Sequence statusi: Complete.

C7LWW2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNGAQVEVAL TQAFSAEELD KWRASLGLSV EGSVLTVRFP HRYFSDWFET
60 70 80 90 100
HARVRFEQAL AGSGLSIAYE CRDRSRSRIV RESRPAGQAL PFGSEFIFDN
110 120 130 140 150
FLVNNKNYFP LASAQEVAQS REAPYNPFVL CGESGSGKSF LLRAIANARS
160 170 180 190 200
EHGADGSYVG GIEDLHELYS SRSDARKFLT SMQLLAVDDL QEIARYRYLQ
210 220 230 240 250
GELLALFDHF HLQRKQMVFA CTGKVGGYTF LAPKLKSRLE WGLSVMLKAP
260 270 280 290 300
DLDIRTQYAQ SRCRERRLDL SKDRILLLAQ RFADLRNLEG CLLKLWAYRE
310 320 330 340 350
LVHDHISDEE FDNILNYLDD RAVTSLSVEQ ILDAVCSKFN LKPEDILSSG
360 370 380 390 400
RRHDLVFARQ VAMYLCRKHL GLSFPELGRA FGGRDHSTVL YSCRKVEQLQ
410 420
RDDKSIKNML HELSDKCLAM NETTLA
Length:426
Mass (Da):48,484
Last modified:October 13, 2009 - v1
Checksum:iD55A4B1D55F29FC1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001629 Genomic DNA Translation: ACU91172.1
RefSeqiWP_015775261.1, NC_013173.1

Genome annotation databases

EnsemblBacteriaiACU91172; ACU91172; Dbac_3097
KEGGidba:Dbac_3097

Similar proteinsi

Entry informationi

Entry nameiC7LWW2_DESBD
AccessioniPrimary (citable) accession number: C7LWW2
Entry historyiIntegrated into UniProtKB/TrEMBL: October 13, 2009
Last sequence update: October 13, 2009
Last modified: March 28, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health