C7LVQ7 (C7LVQ7_DESBD) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Ketol-acid reductoisomerase HAMAP-Rule MF_00435
EC=1.1.1.86 HAMAP-Rule MF_00435

Alternative name(s):
Acetohydroxy-acid isomeroreductase HAMAP-Rule MF_00435
Alpha-keto-beta-hydroxylacyl reductoisomerase HAMAP-Rule MF_00435

Gene names

Name:	ilvC HAMAP-Rule MF_00435
Ordered Locus Names:	Dbac_0410

Organism

Desulfomicrobium baculatum (strain DSM 4028 / VKM B-1378) (Desulfovibrio baculatus) [Complete proteome] [HAMAP] EMBL ACU88536.1

Taxonomic identifier

525897 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › delta/epsilon subdivisions › Deltaproteobacteria › Desulfovibrionales › Desulfomicrobiaceae › Desulfomicrobium › Desulfovibrio baculatus

Protein attributes

Sequence length	329 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP+ = (S)-2-hydroxy-2-ethyl-3-oxobutanoate + NADPH. HAMAP-Rule MF_00435 SAAS SAAS000506 (R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH. HAMAP-Rule MF_00435 SAAS SAAS000506
Pathway	Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4. HAMAP-Rule MF_00435 SAAS SAAS000506 Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4. HAMAP-Rule MF_00435 SAAS SAAS000506
Sequence similarities	Belongs to the ketol-acid reductoisomerase family. HAMAP-Rule MF_00435

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Branched-chain amino acid biosynthesis HAMAP-Rule MF_00435 SAAS SAAS000506
Ligand	NADP HAMAP-Rule MF_00435 SAAS SAAS000506
Molecular function	Isomerase EMBL ACU88536.1 Oxidoreductase HAMAP-Rule MF_00435 SAAS SAAS000506 EMBL ACU88536.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	isoleucine biosynthetic process Inferred from electronic annotation. Source: HAMAP valine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular_function	coenzyme binding Inferred from electronic annotation. Source: InterPro isomerase activity Inferred from electronic annotation. Source: UniProtKB-KW ketol-acid reductoisomerase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	107	1	By similarity HAMAP-Rule MF_00435

Sequences

	Sequence		Length	Mass (Da)
	C7LVQ7 [UniParc]. Last modified October 13, 2009. Version 1. Checksum: 4AD9BEEE20008D0F	FASTA	329	36,435
	10 20 30 40 50 60 MKVYYDKDAD LNILKDKVVA IIGYGSQGHA HAQNLRDSGV QVIIGQRPGG PNWQLAREHG 70 80 90 100 110 120 FEPVSAAEAA KKADLIQILV QDQYQPKVYE EEILPNLAPG KTLVFGHGFN IHYNQIVPPK 130 140 150 160 170 180 DVDVVMIAPK GPGHLVRREF EKGGGVPCLV AVYQDATGQA LGKALAYAAG VGGTRSGVLE 190 200 210 220 230 240 TTFAEETETD LFGEQAVLCG GVSELIRAGF ETLTKAGYQP EIAFFECMHE LKLIVDLLYE 250 260 270 280 290 300 GGFKKMHHSI SDTAEYGDYV TGPRVINEES RKAMQKVLEE IQDGTFARNW ILENKANLPF 310 320 FLARRRQSHE HQVEKVGDSL REMMAWLQK

References

[1]

"Complete genome sequence of Desulfomicrobium baculatum type strain (X)." Copeland A., Spring S., Goker M., Schneider S., Lapidus A., Del Rio T.G., Tice H., Cheng J.F., Chen F., Nolan M., Bruce D., Goodwin L., Pitluck S., Ivanova N., Mavrommatis K., Ovchinnikova G., Pati A., Chen A. , Palaniappan K., Land M., Hauser L., Chang Y.J., Jeffries C.C., Meincke L., Sims D., Brettin T., Detter J.C., Han C., Chain P., Bristow J., Eisen J.A., Markowitz V., Hugenholtz P., Kyrpides N.C., Klenk H.P., Lucas S. Stand. Genomic Sci. 1:29-37(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 4028 / VKM B-1378.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001629 Genomic DNA. Translation: ACU88536.1.
RefSeq	YP_003156952.1. NC_013173.1.
3D structure databases
ProteinModelPortal	C7LVQ7.
ModBase	Search...
Protein-protein interaction databases
STRING	525897.Dbac_0410.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACU88536; ACU88536; Dbac_0410.
GeneID	8376059.
KEGG	dba:Dbac_0410.
PATRIC	21703134. VBIDesBac69216_0425.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0059.
HOGENOM	HOG000016230.
KO	K00053.
OMA	MAYAKGI.
ProtClustDB	PRK05479.
Enzyme and pathway databases
BioCyc	DBAC525897:GI50-428-MONOMER.
UniPathway	UPA00047; UER00056. UPA00049; UER00060.
Family and domain databases
Gene3D	1.10.1040.10. 1 hit.
HAMAP	MF_00435. IlvC.
InterPro	IPR008927. 6-PGluconate_DH_C-like. IPR013023. AcH_isomrdctse. IPR000506. AcH_isomrdctse_C. IPR013328. DH_multihelical. IPR013116. IlvN. [Graphical view]
PANTHER	PTHR21371. PTHR21371. 1 hit.
Pfam	PF01450. IlvC. 1 hit. PF07991. IlvN. 1 hit. [Graphical view]
SUPFAM	SSF48179. 6DGDH_C_like. 1 hit.
TIGRFAMs	TIGR00465. ilvC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

C7LVQ7_DESBD

Accession

Primary (citable) accession number: C7LVQ7

Entry history

Integrated into UniProtKB/TrEMBL:	October 13, 2009
Last sequence update:	October 13, 2009
Last modified:	May 1, 2013
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)