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C7LSH6

- C7LSH6_DESBD

UniProt

C7LSH6 - C7LSH6_DESBD

Protein

Riboflavin biosynthesis protein RibBA

Gene

ribBA

Organism
Desulfomicrobium baculatum (strain DSM 4028 / VKM B-1378) (Desulfovibrio baculatus)
Status
Unreviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 34 (01 Oct 2014)
      Sequence version 1 (13 Oct 2009)
      Previous versions | rss
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    Functioni

    Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.UniRule annotationSAAS annotation
    Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.UniRule annotationSAAS annotation

    Catalytic activityi

    D-ribulose 5-phosphate = formate + L-3,4-dihydroxybutan-2-one 4-phosphate.UniRule annotation
    GTP + 3 H2O = formate + 2,5-diamino-6-hydroxy-4-(5-phospho-D-ribosylamino)pyrimidine + diphosphate.UniRule annotationSAAS annotation

    Cofactori

    Binds 1 zinc ion per subunit.UniRule annotationSAAS annotation
    Binds 2 divalent metal cations per subunit. Magnesium or manganese.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi28 – 281Magnesium or manganese 1UniRule annotation
    Metal bindingi28 – 281Magnesium or manganese 2UniRule annotation
    Binding sitei32 – 321D-ribulose 5-phosphateUniRule annotation
    Sitei126 – 1261Essential for DHBP synthase activityUniRule annotation
    Binding sitei164 – 1641D-ribulose 5-phosphateUniRule annotation
    Sitei164 – 1641Essential for DHBP synthase activityUniRule annotation
    Metal bindingi257 – 2571Zinc; catalyticUniRule annotation
    Metal bindingi268 – 2681Zinc; catalyticUniRule annotation
    Metal bindingi270 – 2701Zinc; catalyticUniRule annotation
    Binding sitei273 – 2731GTPUniRule annotation
    Binding sitei317 – 3171GTPUniRule annotation
    Active sitei329 – 3291Proton acceptor; for GTP cyclohydrolase activityUniRule annotation
    Active sitei331 – 3311Nucleophile; for GTP cyclohydrolase activityUniRule annotation
    Binding sitei352 – 3521GTPUniRule annotation
    Binding sitei357 – 3571GTPUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi252 – 2565GTPUniRule annotation
    Nucleotide bindingi295 – 2973GTPUniRule annotation

    GO - Molecular functioni

    1. 3,4-dihydroxy-2-butanone-4-phosphate synthase activity Source: UniProtKB-HAMAP
    2. GTP binding Source: UniProtKB-KW
    3. GTP cyclohydrolase II activity Source: UniProtKB-HAMAP
    4. magnesium ion binding Source: UniProtKB-HAMAP
    5. manganese ion binding Source: UniProtKB-HAMAP
    6. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. riboflavin biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    HydrolaseUniRule annotationImported, LyaseUniRule annotation

    Keywords - Biological processi

    Riboflavin biosynthesisUniRule annotationSAAS annotation

    Keywords - Ligandi

    GTP-bindingUniRule annotationSAAS annotation, MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding, ZincUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciDBAC525897:GI50-62-MONOMER.
    UniPathwayiUPA00275; UER00399.
    UPA00275; UER00400.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Riboflavin biosynthesis protein RibBAUniRule annotation
    Gene namesi
    Name:ribBAUniRule annotation
    Ordered Locus Names:Dbac_0060Imported
    OrganismiDesulfomicrobium baculatum (strain DSM 4028 / VKM B-1378) (Desulfovibrio baculatus)Imported
    Taxonomic identifieri525897 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfovibrionalesDesulfomicrobiaceaeDesulfomicrobium
    ProteomesiUP000002216: Chromosome

    Interactioni

    Protein-protein interaction databases

    STRINGi525897.Dbac_0060.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 201201DHBP synthaseUniRule annotationAdd
    BLAST
    Regioni27 – 282D-ribulose 5-phosphate bindingUniRule annotation
    Regioni202 – 404203GTP cyclohydrolase IIUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    In the C-terminal section; belongs to the GTP cyclohydrolase II family.UniRule annotation
    In the N-terminal section; belongs to the DHBP synthase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0108.
    HOGENOMiHOG000115440.
    KOiK14652.
    OMAiGKGLICM.
    OrthoDBiEOG679TK8.

    Family and domain databases

    Gene3Di3.90.870.10. 1 hit.
    HAMAPiMF_00179. RibA.
    MF_00180. RibB.
    MF_01283. RibBA.
    InterProiIPR017945. DHBP_synth_RibB-like_a/b_dom.
    IPR000422. DHBP_synthase_RibB.
    IPR000926. GTP_CycHdrlaseII_RibA.
    IPR016299. Riboflavin_synth_RibBA.
    [Graphical view]
    PfamiPF00926. DHBP_synthase. 1 hit.
    PF00925. GTP_cyclohydro2. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001259. RibA. 1 hit.
    SUPFAMiSSF55821. SSF55821. 1 hit.
    TIGRFAMsiTIGR00505. ribA. 1 hit.
    TIGR00506. ribB. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    C7LSH6-1 [UniParc]FASTAAdd to Basket

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    MHKCSAEEAI KEIKAGKMII LVDDEDRENE GDLTIAAEMV TPEAINFMAK    50
    YGRGLICLAL EPALVDKLEL PLMARRNTSK FGTNFTVSIE AKQGVTTGIS 100
    AHDRALTIQT AVADQTTPED LATPGHIFPL RAKPGGVLVR AGQTEGSVDL 150
    ARLAGLKGAA VICEIMNDDG SMSRMPDLRK FAEEHDMKIA TIADLIAYRS 200
    RKDSLVRRVA EARMPTCYGE FTIVAYENDI DSHTHIALVK GEINEETPVL 250
    VRVHSECLTG DVFGSMRCDC GSQLQRAMQM VNDEGAGVIL YMRQEGRGIG 300
    LGNKIKAYHL QDEGRDTVEA NLELGFAPDL RDYGLGAQIL VDLGVKRMRL 350
    LTNNPKKIIG LEGYGLKVEE RISIEIPACD DNKCYLHTKH SKLGHLLQFE 400
    AENK 404
    Length:404
    Mass (Da):44,379
    Last modified:October 13, 2009 - v1
    Checksum:iD4CB39048F1F5266
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001629 Genomic DNA. Translation: ACU88190.1.
    RefSeqiYP_003156606.1. NC_013173.1.

    Genome annotation databases

    EnsemblBacteriaiACU88190; ACU88190; Dbac_0060.
    GeneIDi8375693.
    KEGGidba:Dbac_0060.
    PATRICi21702370. VBIDesBac69216_0058.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001629 Genomic DNA. Translation: ACU88190.1 .
    RefSeqi YP_003156606.1. NC_013173.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 525897.Dbac_0060.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACU88190 ; ACU88190 ; Dbac_0060 .
    GeneIDi 8375693.
    KEGGi dba:Dbac_0060.
    PATRICi 21702370. VBIDesBac69216_0058.

    Phylogenomic databases

    eggNOGi COG0108.
    HOGENOMi HOG000115440.
    KOi K14652.
    OMAi GKGLICM.
    OrthoDBi EOG679TK8.

    Enzyme and pathway databases

    UniPathwayi UPA00275 ; UER00399 .
    UPA00275 ; UER00400 .
    BioCyci DBAC525897:GI50-62-MONOMER.

    Family and domain databases

    Gene3Di 3.90.870.10. 1 hit.
    HAMAPi MF_00179. RibA.
    MF_00180. RibB.
    MF_01283. RibBA.
    InterProi IPR017945. DHBP_synth_RibB-like_a/b_dom.
    IPR000422. DHBP_synthase_RibB.
    IPR000926. GTP_CycHdrlaseII_RibA.
    IPR016299. Riboflavin_synth_RibBA.
    [Graphical view ]
    Pfami PF00926. DHBP_synthase. 1 hit.
    PF00925. GTP_cyclohydro2. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001259. RibA. 1 hit.
    SUPFAMi SSF55821. SSF55821. 1 hit.
    TIGRFAMsi TIGR00505. ribA. 1 hit.
    TIGR00506. ribB. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 4028 / VKM B-1378Imported.

    Entry informationi

    Entry nameiC7LSH6_DESBD
    AccessioniPrimary (citable) accession number: C7LSH6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 13, 2009
    Last sequence update: October 13, 2009
    Last modified: October 1, 2014
    This is version 34 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzymeUniRule annotation, Reference proteomeImported

    External Data

    Dasty 3