C7LII3 (C7LII3_BRUMC) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Alkyl hydroperoxide reductase AhpD HAMAP MF_01676
EC=1.11.1.15 HAMAP MF_01676

Alternative name(s):
Alkylhydroperoxidase AhpD HAMAP MF_01676

Gene names

Name:	ahpD HAMAP MF_01676 EMBL ACU49821.1
Ordered Locus Names:	BMI_II701

Organism

Brucella microti (strain CCM 4915) [Complete proteome] [HAMAP]

Taxonomic identifier

568815 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella

Protein attributes

Sequence length	175 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity By similarity. HAMAP MF_01676 SAAS SAAS004674
Catalytic activity	2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH. HAMAP MF_01676 SAAS SAAS004674
Sequence similarities	Belongs to the AhpD family. HAMAP MF_01676

Ontologies

Keywords
Domain	Redox-active center HAMAP MF_01676 SAAS SAAS004674
Molecular function	Antioxidant HAMAP MF_01676 SAAS SAAS004674 Oxidoreductase Peroxidase HAMAP MF_01676 SAAS SAAS004674
PTM	Disulfide bond HAMAP MF_01676 SAAS SAAS004674
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	alkyl hydroperoxide reductase activity Inferred from electronic annotation. Source: HAMAP peroxidase activity Inferred from electronic annotation. Source: UniProtKB-KW peroxiredoxin activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	131	1	Proton donor By similarity HAMAP MF_01676
	Active site	134	1	Cysteine sulfenic acid (-SOH) intermediate By similarity HAMAP MF_01676
Amino acid modifications
	Disulfide bond	131 ↔ 134		Alternate By similarity HAMAP MF_01676
	Disulfide bond	134		Interchain (with AhpC); in linked form By similarity HAMAP MF_01676

Sequences

	Sequence		Length	Mass (Da)
	C7LII3 [UniParc]. Last modified October 13, 2009. Version 1. Checksum: D8E719D7F4B571CA	FASTA	175	18,769
	10 20 30 40 50 60 MSIDDLKSKI PDFAKDVRLN LSSMASDETL TPQQKYGLFV ACGIASRNAD VRKALVAEAA 70 80 90 100 110 120 GKVDASVIQA AKAAASIMGM NNVYYRFVHL ASNKDYRTMP ARLRMNVISN PGVDKVDFEL 130 140 150 160 170 WSLAVSAING CGMCIDAHED VLRKANVTAE AIQAAVRFAS IIQSAAIALE AADTE

References

[1]	"Brucella microti: the genome sequence of an emerging pathogen." Audic S., Lescot M., Claverie J.-M., Scholz H.C. BMC Genomics 10:352-352(2009) [PubMed: 19653890] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001579 Genomic DNA. Translation: ACU49821.1.
RefSeq	YP_003105483.1. NC_013118.1.
3D structure databases
ProteinModelPortal	C7LII3.
ModBase	Search...
Protein-protein interaction databases
STRING	C7LII3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	8318477.
GenomeReviews	Gene locus BMI_II701 in contig CP001579_GR.
KEGG	bmr:BMI_II701.
PATRIC	17803894. VBIBruMic92249_0688.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	RAGLRMN.
ProtClustDB	CLSK898877.
Family and domain databases
HAMAP	MF_01676. AhpD. [Tree]
InterPro	IPR004674. AhpD. IPR004675. AhpD_core. IPR003779. CMD. [Graphical view]
KO	K04756.
Pfam	PF02627. CMD. 1 hit. [Graphical view]
TIGRFAMs	TIGR00777. AhpD. 1 hit. TIGR00778. AhpD_dom. 1 hit.
ProtoNet	Search...

Entry information

Entry name

C7LII3_BRUMC

Accession

Primary (citable) accession number: C7LII3

Entry history

Integrated into UniProtKB/TrEMBL:	October 13, 2009
Last sequence update:	October 13, 2009
Last modified:	December 14, 2011
This is version 19 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)