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Protein

Glutamate decarboxylase

Gene

gadB

Organism
Brucella microti (strain CCM 4915)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamate = 4-aminobutanoate + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

DecarboxylaseUniRule annotation, Lyase

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Enzyme and pathway databases

BioCyciBMIC568815:GJUE-2536-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate decarboxylaseUniRule annotation (EC:4.1.1.15UniRule annotation)
Gene namesi
Name:gadBImported
Ordered Locus Names:BMI_II334Imported
OrganismiBrucella microti (strain CCM 4915)Imported
Taxonomic identifieri568815 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000002188 Componenti: Chromosome 2

Family & Domainsi

Sequence similaritiesi

Belongs to the group II decarboxylase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0076.
HOGENOMiHOG000070228.
KOiK01580.
OMAiDPDLVWD.
OrthoDBiEOG6TFCPW.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR021115. Pyridoxal-P_BS.
[Graphical view]
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.
PROSITEiPS00392. DDC_GAD_HDC_YDC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C7LHI0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKITLEVIMT GSNYPARDLI ASVFGTEALQ EIAASRGFPE KEMQANAVYQ
60 70 80 90 100
IIHDELFLDG NARQNLATFC QTWDDDYVHK LMDLSINKNW IDKEEYPQSA
110 120 130 140 150
AIDLRCVNMV ADLWNAPKFA DNATGTNTIG SSEACMLGGM AMKWRWRKKM
160 170 180 190 200
QEMGKPTDKP NFVCGPVQVC WHKFARYWDV EIREIPMEPG RLFMGPEQML
210 220 230 240 250
EAVDENTIGV VPTFGVTYTG NYEFPEPLQD ALDKLQKTKG LDIDIHVDAA
260 270 280 290 300
SGGFLAPFCA PDIPWDFRLP RVKSISASGH KYGLAPLGCG WVVWRDKEAL
310 320 330 340 350
PEELIFNVDY LGGQVGTFAI NFSRPAGQVI SQYYEFMRLG REGYTKVQQA
360 370 380 390 400
AYRVAQYIAR EIEPLGPYEF ICAGEEKGGI PAVCFRIREG EDPGYSLYDL
410 420 430 440 450
SERLRLTGWQ VPAFALSGKA SDITVMRVMC RRGFEMDLAA LFIRDFKAGI
460 470
EFFKSHPSPK ITPSMGTGFH HT
Length:472
Mass (Da):53,112
Last modified:October 13, 2009 - v1
Checksum:i366F30DCCA81D455
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001579 Genomic DNA. Translation: ACU49468.1.
RefSeqiWP_015799832.1. NC_013118.1.
YP_003105130.1. NC_013118.1.

Genome annotation databases

EnsemblBacteriaiACU49468; ACU49468; BMI_II334.
KEGGibmr:BMI_II334.
PATRICi17803159. VBIBruMic92249_0326.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001579 Genomic DNA. Translation: ACU49468.1.
RefSeqiWP_015799832.1. NC_013118.1.
YP_003105130.1. NC_013118.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACU49468; ACU49468; BMI_II334.
KEGGibmr:BMI_II334.
PATRICi17803159. VBIBruMic92249_0326.

Phylogenomic databases

eggNOGiCOG0076.
HOGENOMiHOG000070228.
KOiK01580.
OMAiDPDLVWD.
OrthoDBiEOG6TFCPW.

Enzyme and pathway databases

BioCyciBMIC568815:GJUE-2536-MONOMER.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR021115. Pyridoxal-P_BS.
[Graphical view]
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.
PROSITEiPS00392. DDC_GAD_HDC_YDC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Brucella microti: the genome sequence of an emerging pathogen."
    Audic S., Lescot M., Claverie J.-M., Scholz H.C.
    BMC Genomics 10:352-352(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CCM 4915Imported.

Entry informationi

Entry nameiC7LHI0_BRUMC
AccessioniPrimary (citable) accession number: C7LHI0
Entry historyi
Integrated into UniProtKB/TrEMBL: October 13, 2009
Last sequence update: October 13, 2009
Last modified: June 24, 2015
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.