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C7LCD4 (C7LCD4_BRUMC) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 17. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
NADPH-dependent 7-cyano-7-deazaguanine reductase HAMAP MF_00818
EC=1.7.1.13 HAMAP MF_00818
Alternative name(s):
7-cyano-7-carbaguanine reductase HAMAP MF_00818
NADPH-dependent nitrile oxidoreductase HAMAP MF_00818
PreQ(0) reductase HAMAP MF_00818
Gene names
Name:queF HAMAP MF_00818 EMBL ACU48169.1
Ordered Locus Names:BMI_I1194
OrganismBrucella microti (strain CCM 4915) [Complete proteome] [HAMAP]
Taxonomic identifier568815 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella

Protein attributes

Sequence length155 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) By similarity. HAMAP MF_00818 SAAS SAAS016856

Catalytic activity

7-aminomethyl-7-carbaguanine + 2 NADP+ = 7-cyano-7-carbaguanine + 2 NADPH. HAMAP MF_00818 SAAS SAAS016856

Pathway

tRNA modification; tRNA-queuosine biosynthesis. HAMAP MF_00818 SAAS SAAS016856

Subcellular location

Cytoplasm By similarity HAMAP MF_00818 SAAS SAAS016856.

Sequence similarities

Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily. HAMAP MF_00818

Sequences

Sequence LengthMass (Da)Tools
C7LCD4 [UniParc].

Last modified October 13, 2009. Version 1.
Checksum: EB93CD3CC760ADE1

FASTA15517,416
        10         20         30         40         50         60 
MSENTIYSGL KQLGSHTDIP LTPEEAVLER VANPQEGTPY CVRFTAPEFT SLCPMTGQPD 

        70         80         90        100        110        120 
FAHLVIDYVP GKWLVESKSL KLFLFSFRNH GAFHEDCTVT IGKRLVDLLE PEWLRIGGYW 

       130        140        150 
YPRGGIPIDV FYQTGAAPLN VWIPEQGVAN YRGRG

« Hide

References

[1]"Brucella microti: the genome sequence of an emerging pathogen."
Audic S., Lescot M., Claverie J.-M., Scholz H.C.
BMC Genomics 10:352-352(2009) [PubMed: 19653890] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001578 Genomic DNA. Translation: ACU48169.1.
RefSeqYP_003107118.1. NC_013119.1.

3D structure databases

ProteinModelPortalC7LCD4.
ModBaseSearch...

Protein-protein interaction databases

STRINGC7LCD4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID8320755.
GenomeReviewsGene locus BMI_I1194 in contig CP001578_GR.
KEGGbmr:BMI_I1194.
PATRIC17807396. VBIBruMic92249_2405.

Organism-specific databases

CMRSearch...

Phylogenomic databases

OMAHEDCTVA.
ProtClustDBPRK13258.

Family and domain databases

HAMAPMF_00818. QueF_type1.
[Tree]
InterProIPR016856. CN_OxRdtase_NADPH-dep_QueF.
IPR020602. GTP_CycHdrlase_I/CN_OxRdtase.
[Graphical view]
KOK09457.
PfamPF01227. GTP_cyclohydroI. 1 hit.
[Graphical view]
PIRSFPIRSF027377. Nitrile_oxidored_QueF. 1 hit.
TIGRFAMsTIGR03139. QueF-II. 1 hit.
ProtoNetSearch...

Entry information

Entry nameC7LCD4_BRUMC
AccessionPrimary (citable) accession number: C7LCD4
Entry history
Integrated into UniProtKB/TrEMBL: October 13, 2009
Last sequence update: October 13, 2009
Last modified: December 14, 2011
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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