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Protein

Alanine racemase

Gene

APA42C_24990

Organism
Acetobacter pasteurianus IFO 3283-01-42C
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei52 – 521Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei151 – 1511SubstrateUniRule annotation
Active sitei273 – 2731Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei321 – 3211Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciAPAS634458:GL78-2432-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
ORF Names:APA42C_24990Imported
OrganismiAcetobacter pasteurianus IFO 3283-01-42CImported
Taxonomic identifieri634458 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesAcetobacteraceaeAcetobacter
ProteomesiUP000000952: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei52 – 521N6-(pyridoxal phosphate)lysineUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliC7KW60.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

KOiK01775.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C7KW60-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVVNTVSSS ARTLWPASRA GAVLTVNLSA IAENYRYLKS RLGKTACAAV
60 70 80 90 100
VKADAYGLGV AQVAPVLEKA GAEHFFVAHV DEGLALRPFL SPHTSVTVLH
110 120 130 140 150
GPRPDAAEVC VRNNLRPVLN SLEQVAVLRD LAAKMDKPLD VAIQLDTGMS
160 170 180 190 200
RFGLSEADIH KLVASPELLK GLFVSLVMSH LACADTPQNP ANTMQRERFE
210 220 230 240 250
AYARILPQAA LSLSASSGIF LGPQFHFDLV RPGAALYGVA PQNEGDNPLK
260 270 280 290 300
PVVGLQAHIL QIRHLSKGDR VGYGLTWQAH GPCRVATIAT GYADGFARAG
310 320 330 340 350
AAAGCAWYKG YRLPILGRIS MDSMTVDLSA VPEGLLEEDS MVELLNESYG
360 370 380
VDAVAKAEGT IGYEVLTSLG RRYHRVYAAA A
Length:381
Mass (Da):40,610
Last modified:October 13, 2009 - v1
Checksum:iB5110A7F954991C2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP011163 Genomic DNA. Translation: BAI18826.1.
RefSeqiYP_005502898.1. NC_017150.1.

Genome annotation databases

EnsemblBacteriaiBAI18826; BAI18826; APA42C_24990.
GeneIDi12091862.
KEGGiapw:APA42C_24990.
PATRICi36849323. VBIAcePas142730_2517.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP011163 Genomic DNA. Translation: BAI18826.1.
RefSeqiYP_005502898.1. NC_017150.1.

3D structure databases

ProteinModelPortaliC7KW60.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAI18826; BAI18826; APA42C_24990.
GeneIDi12091862.
KEGGiapw:APA42C_24990.
PATRICi36849323. VBIAcePas142730_2517.

Phylogenomic databases

KOiK01775.

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.
BioCyciAPAS634458:GL78-2432-MONOMER.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: IFO 3283Imported.

Entry informationi

Entry nameiC7KW60_ACEPA
AccessioniPrimary (citable) accession number: C7KW60
Entry historyi
Integrated into UniProtKB/TrEMBL: October 13, 2009
Last sequence update: October 13, 2009
Last modified: March 4, 2015
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.