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C7KGG6

- C7KGG6_ACEPA

UniProt

C7KGG6 - C7KGG6_ACEPA

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Protein

Lipoyl synthase

Gene
lipA, APA26_12140
Organism
Acetobacter pasteurianus IFO 3283-26
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives By similarity.UniRule annotation

Catalytic activityi

Protein N(6)-(octanoyl)lysine + 2 sulfur-(sulfur carrier) + 2 S-adenosyl-L-methionine = protein N(6)-(lipoyl)lysine + 2 (sulfur carrier) + 2 L-methionine + 2 5'-deoxyadenosine.UniRule annotation

Cofactori

Binds 2 4Fe-4S clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi65 – 651Iron-sulfur 1 (4Fe-4S) By similarityUniRule annotation
Metal bindingi70 – 701Iron-sulfur 1 (4Fe-4S) By similarityUniRule annotation
Metal bindingi76 – 761Iron-sulfur 1 (4Fe-4S) By similarityUniRule annotation
Metal bindingi91 – 911Iron-sulfur 2 (4Fe-4S-S-AdoMet) By similarityUniRule annotation
Metal bindingi95 – 951Iron-sulfur 2 (4Fe-4S-S-AdoMet) By similarityUniRule annotation
Metal bindingi98 – 981Iron-sulfur 2 (4Fe-4S-S-AdoMet) By similarityUniRule annotation

GO - Molecular functioni

  1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-HAMAP
  2. lipoate synthase activity Source: UniProtKB-HAMAP
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. protein lipoylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

TransferaseUniRule annotation

Keywords - Ligandi

4Fe-4SUniRule annotation, Iron, Iron-sulfur, Metal-binding, S-adenosyl-L-methionineUniRule annotation

Enzyme and pathway databases

BioCyciAPAS634456:GL79-1218-MONOMER.
UniPathwayiUPA00538; UER00593.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipoyl synthaseUniRule annotation (EC:2.8.1.8UniRule annotation)
Alternative name(s):
Lip-syn
Lipoate synthase
Lipoic acid synthase
Sulfur insertion protein LipA
Gene namesi
Name:lipAUniRule annotation
ORF Names:APA26_12140Imported
OrganismiAcetobacter pasteurianus IFO 3283-26Imported
Taxonomic identifieri634456 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesAcetobacteraceaeAcetobacter
ProteomesiUP000000951: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliC7KGG6.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK03644.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00206. Lipoyl_synth.
InterProiIPR013785. Aldolase_TIM.
IPR006638. Elp3/MiaB/NifB.
IPR003698. Lipoyl_synth.
IPR007197. rSAM.
[Graphical view]
PANTHERiPTHR10949. PTHR10949. 1 hit.
PfamiPF04055. Radical_SAM. 1 hit.
[Graphical view]
PIRSFiPIRSF005963. Lipoyl_synth. 1 hit.
SMARTiSM00729. Elp3. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00510. lipA. 1 hit.

Sequencei

Sequence statusi: Complete.

C7KGG6-1 [UniParc]FASTAAdd to Basket

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MSIRVVIDHR TGGSSPNKLR HPEKAHRPDN PIARKPDWIR VKAPNHPVYH    50
ETRALMRSNK LVTVCEEAAC PNIGECWSQR HATMMIMGEI CTRACAFCNV 100
TTGLPHALDA DEPTRVAEAV ARLGLRHVVI TSVDRDDLED GGAHHFARVI 150
HAIRAAAPET TIEILTPDFL RKKNALEVVV EARPDVFNHN LETVPRLYPT 200
IRPGARYYQS LRLLDRVKQL DASIFTKSGL MLGLGEEKME LAQVMDDLRV 250
ADVDFITMGQ YLQPTVKHAP VARFVTPAEF EDYGTMARVK GFLQVSSSPL 300
TRSSYHADAD FAALRDARNA RLKEDQ 326
Length:326
Mass (Da):36,515
Last modified:October 13, 2009 - v1
Checksum:i6558A0DE698EAFB5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP011149 Genomic DNA. Translation: BAI11557.1.
RefSeqiYP_005498857.1. NC_017146.1.

Genome annotation databases

EnsemblBacteriaiBAI11557; BAI11557; APA26_12140.
GeneIDi12087627.
KEGGiapx:APA26_12140.
PATRICi36879179. VBIAcePas144932_1284.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP011149 Genomic DNA. Translation: BAI11557.1 .
RefSeqi YP_005498857.1. NC_017146.1.

3D structure databases

ProteinModelPortali C7KGG6.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAI11557 ; BAI11557 ; APA26_12140 .
GeneIDi 12087627.
KEGGi apx:APA26_12140.
PATRICi 36879179. VBIAcePas144932_1284.

Phylogenomic databases

KOi K03644.

Enzyme and pathway databases

UniPathwayi UPA00538 ; UER00593 .
BioCyci APAS634456:GL79-1218-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_00206. Lipoyl_synth.
InterProi IPR013785. Aldolase_TIM.
IPR006638. Elp3/MiaB/NifB.
IPR003698. Lipoyl_synth.
IPR007197. rSAM.
[Graphical view ]
PANTHERi PTHR10949. PTHR10949. 1 hit.
Pfami PF04055. Radical_SAM. 1 hit.
[Graphical view ]
PIRSFi PIRSF005963. Lipoyl_synth. 1 hit.
SMARTi SM00729. Elp3. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00510. lipA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Whole-genome analyses reveal genetic instability of Acetobacter pasteurianus."
    Azuma Y., Hosoyama A., Matsutani M., Furuya N., Horikawa H., Harada T., Hirakawa H., Kuhara S., Matsushita K., Fujita N., Shirai M.
    Submitted (APR-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: IFO 3283Imported.

Entry informationi

Entry nameiC7KGG6_ACEPA
AccessioniPrimary (citable) accession number: C7KGG6
Entry historyi
Integrated into UniProtKB/TrEMBL: October 13, 2009
Last sequence update: October 13, 2009
Last modified: June 11, 2014
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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