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C7KGG6

- C7KGG6_ACEPA

UniProt

C7KGG6 - C7KGG6_ACEPA

Protein

Lipoyl synthase

Gene

lipA

Organism
Acetobacter pasteurianus IFO 3283-26
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 28 (01 Oct 2014)
      Sequence version 1 (13 Oct 2009)
      Previous versions | rss
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    Functioni

    Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.UniRule annotation

    Catalytic activityi

    Protein N(6)-(octanoyl)lysine + 2 sulfur-(sulfur carrier) + 2 S-adenosyl-L-methionine = protein N(6)-(lipoyl)lysine + 2 (sulfur carrier) + 2 L-methionine + 2 5'-deoxyadenosine.UniRule annotation

    Cofactori

    Binds 2 4Fe-4S clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi65 – 651Iron-sulfur 1 (4Fe-4S)UniRule annotation
    Metal bindingi70 – 701Iron-sulfur 1 (4Fe-4S)UniRule annotation
    Metal bindingi76 – 761Iron-sulfur 1 (4Fe-4S)UniRule annotation
    Metal bindingi91 – 911Iron-sulfur 2 (4Fe-4S-S-AdoMet)UniRule annotation
    Metal bindingi95 – 951Iron-sulfur 2 (4Fe-4S-S-AdoMet)UniRule annotation
    Metal bindingi98 – 981Iron-sulfur 2 (4Fe-4S-S-AdoMet)UniRule annotation

    GO - Molecular functioni

    1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-HAMAP
    2. lipoate synthase activity Source: UniProtKB-HAMAP
    3. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. protein lipoylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    TransferaseUniRule annotation

    Keywords - Ligandi

    4Fe-4SUniRule annotation, Iron, Iron-sulfur, Metal-binding, S-adenosyl-L-methionineUniRule annotation

    Enzyme and pathway databases

    BioCyciAPAS634456:GL79-1218-MONOMER.
    UniPathwayiUPA00538; UER00593.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lipoyl synthaseUniRule annotation (EC:2.8.1.8UniRule annotation)
    Alternative name(s):
    Lip-synUniRule annotation
    Lipoate synthaseUniRule annotation
    Lipoic acid synthaseUniRule annotation
    Sulfur insertion protein LipAUniRule annotation
    Gene namesi
    Name:lipAUniRule annotation
    ORF Names:APA26_12140Imported
    OrganismiAcetobacter pasteurianus IFO 3283-26Imported
    Taxonomic identifieri634456 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesAcetobacteraceaeAcetobacter
    ProteomesiUP000000951: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliC7KGG6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the radical SAM superfamily. Lipoyl synthase family.UniRule annotation

    Phylogenomic databases

    KOiK03644.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    HAMAPiMF_00206. Lipoyl_synth.
    InterProiIPR013785. Aldolase_TIM.
    IPR006638. Elp3/MiaB/NifB.
    IPR003698. Lipoyl_synth.
    IPR007197. rSAM.
    [Graphical view]
    PANTHERiPTHR10949. PTHR10949. 1 hit.
    PfamiPF04055. Radical_SAM. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005963. Lipoyl_synth. 1 hit.
    SMARTiSM00729. Elp3. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00510. lipA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    C7KGG6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSIRVVIDHR TGGSSPNKLR HPEKAHRPDN PIARKPDWIR VKAPNHPVYH    50
    ETRALMRSNK LVTVCEEAAC PNIGECWSQR HATMMIMGEI CTRACAFCNV 100
    TTGLPHALDA DEPTRVAEAV ARLGLRHVVI TSVDRDDLED GGAHHFARVI 150
    HAIRAAAPET TIEILTPDFL RKKNALEVVV EARPDVFNHN LETVPRLYPT 200
    IRPGARYYQS LRLLDRVKQL DASIFTKSGL MLGLGEEKME LAQVMDDLRV 250
    ADVDFITMGQ YLQPTVKHAP VARFVTPAEF EDYGTMARVK GFLQVSSSPL 300
    TRSSYHADAD FAALRDARNA RLKEDQ 326
    Length:326
    Mass (Da):36,515
    Last modified:October 13, 2009 - v1
    Checksum:i6558A0DE698EAFB5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP011149 Genomic DNA. Translation: BAI11557.1.
    RefSeqiYP_005498857.1. NC_017146.1.

    Genome annotation databases

    EnsemblBacteriaiBAI11557; BAI11557; APA26_12140.
    GeneIDi12087627.
    KEGGiapx:APA26_12140.
    PATRICi36879179. VBIAcePas144932_1284.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP011149 Genomic DNA. Translation: BAI11557.1 .
    RefSeqi YP_005498857.1. NC_017146.1.

    3D structure databases

    ProteinModelPortali C7KGG6.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAI11557 ; BAI11557 ; APA26_12140 .
    GeneIDi 12087627.
    KEGGi apx:APA26_12140.
    PATRICi 36879179. VBIAcePas144932_1284.

    Phylogenomic databases

    KOi K03644.

    Enzyme and pathway databases

    UniPathwayi UPA00538 ; UER00593 .
    BioCyci APAS634456:GL79-1218-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    HAMAPi MF_00206. Lipoyl_synth.
    InterProi IPR013785. Aldolase_TIM.
    IPR006638. Elp3/MiaB/NifB.
    IPR003698. Lipoyl_synth.
    IPR007197. rSAM.
    [Graphical view ]
    PANTHERi PTHR10949. PTHR10949. 1 hit.
    Pfami PF04055. Radical_SAM. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005963. Lipoyl_synth. 1 hit.
    SMARTi SM00729. Elp3. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00510. lipA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: IFO 3283Imported.

    Entry informationi

    Entry nameiC7KGG6_ACEPA
    AccessioniPrimary (citable) accession number: C7KGG6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 13, 2009
    Last sequence update: October 13, 2009
    Last modified: October 1, 2014
    This is version 28 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3