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C7K5K9

- C7K5K9_ACEPA

UniProt

C7K5K9 - C7K5K9_ACEPA

Protein

Isocitrate dehydrogenase [NADP]

Gene

APA22_06250

Organism
Acetobacter pasteurianus IFO 3283-22
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 32 (01 Oct 2014)
      Sequence version 1 (13 Oct 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei77 – 771SubstrateUniRule annotation
    Binding sitei82 – 821NADP
    Binding sitei109 – 1091SubstrateUniRule annotation
    Binding sitei132 – 1321SubstrateUniRule annotation
    Sitei139 – 1391Critical for catalysisUniRule annotation
    Sitei211 – 2111Critical for catalysisUniRule annotation
    Metal bindingi251 – 2511Magnesium or manganeseUniRule annotation
    Binding sitei259 – 2591NADP
    Metal bindingi274 – 2741Magnesium or manganeseUniRule annotation
    Binding sitei327 – 3271NADP; via amide nitrogen and carbonyl oxygen

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi75 – 773NADP
    Nucleotide bindingi309 – 3146NADP

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. magnesium ion binding Source: InterPro
    3. NAD binding Source: InterPro

    GO - Biological processi

    1. isocitrate metabolic process Source: InterPro
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotation

    Keywords - Biological processi

    Tricarboxylic acid cycleUniRule annotation

    Keywords - Ligandi

    MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

    Enzyme and pathway databases

    BioCyciAPAS634455:GL7C-625-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
    Gene namesi
    ORF Names:APA22_06250Imported
    OrganismiAcetobacter pasteurianus IFO 3283-22Imported
    Taxonomic identifieri634455 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesAcetobacteraceaeAcetobacter
    ProteomesiUP000000950: Chromosome

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni94 – 1007Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

    Phylogenomic databases

    KOiK00031.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR004790. Isocitrate_DH_NADP.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PANTHERiPTHR11822. PTHR11822. 1 hit.
    PfamiPF00180. Iso_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000108. IDH_NADP. 1 hit.
    TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
    PROSITEiPS00470. IDH_IMDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C7K5K9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAKIKVKNPV VEMDGDEMTR IIWHFIRERL ILPYLDIDLK YYDLGIENRD    50
    ATDDKVTVEA AEATKRYGVA VKCATITPDE ARVKEFGLKK MWRSPNGTIR 100
    NILDGTIFRE PIICSNVPRL VPHWTKPIVI GRHAYGDIYR AAETKIPGPG 150
    KVTLNYIPED GGEPITLDVH DFKGPGVALG MHNTRASIEG FARASFSYGR 200
    DRKLPVYLST KNTILKAYDG MFKDVFQEVY EKEFKAEFEK LGLTYEHRLI 250
    DDMVACALKW PGGYVWACKN YDGDVESDIV AQGFGSLGLM TSVLLSPKGD 300
    VVEAEAAHGT VTRHYREHQK GKPTSTNPIA SIFAWTRGLA YRGRFDDTPD 350
    VVHFANTLEK VCVDTVEGGQ MTKDLALLVG NGTKWLDTQP FLDVLDEKLK 400
    QALAKG 406
    Length:406
    Mass (Da):45,449
    Last modified:October 13, 2009 - v1
    Checksum:iA80F02387D8F68BD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP011142 Genomic DNA. Translation: BAI07921.1.
    RefSeqiYP_005489167.1. NC_017125.1.

    Genome annotation databases

    EnsemblBacteriaiBAI07921; BAI07921; APA22_06250.
    GeneIDi12077331.
    KEGGiapq:APA22_06250.
    PATRICi36871417. VBIAcePas142344_0664.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP011142 Genomic DNA. Translation: BAI07921.1 .
    RefSeqi YP_005489167.1. NC_017125.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAI07921 ; BAI07921 ; APA22_06250 .
    GeneIDi 12077331.
    KEGGi apq:APA22_06250.
    PATRICi 36871417. VBIAcePas142344_0664.

    Phylogenomic databases

    KOi K00031.

    Enzyme and pathway databases

    BioCyci APAS634455:GL7C-625-MONOMER.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR004790. Isocitrate_DH_NADP.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    PANTHERi PTHR11822. PTHR11822. 1 hit.
    Pfami PF00180. Iso_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000108. IDH_NADP. 1 hit.
    TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
    PROSITEi PS00470. IDH_IMDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: IFO 3283Imported.

    Entry informationi

    Entry nameiC7K5K9_ACEPA
    AccessioniPrimary (citable) accession number: C7K5K9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 13, 2009
    Last sequence update: October 13, 2009
    Last modified: October 1, 2014
    This is version 32 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3