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Protein

Acetyltransferase component of pyruvate dehydrogenase complex

Gene

APA07_12160

Organism
Acetobacter pasteurianus IFO 3283-07
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.UniRule annotation

Catalytic activityi

Acetyl-CoA + enzyme N(6)-(dihydrolipoyl)lysine = CoA + enzyme N(6)-(S-acetyldihydrolipoyl)lysine.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • (R)-lipoateUniRule annotationNote: Binds 1 lipoyl cofactor covalently.UniRule annotation
  • (R)-lipoateUniRule annotationNote: Binds 2 lipoyl cofactors covalently.UniRule annotation
  • (R)-lipoateUniRule annotationNote: Binds 3 lipoyl cofactors covalently.UniRule annotation

GO - Molecular functioni

  1. dihydrolipoyllysine-residue acetyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. pyruvate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

AcyltransferaseUniRule annotation, Transferase

Enzyme and pathway databases

BioCyciAPAS634454:GL7B-1218-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyltransferase component of pyruvate dehydrogenase complexUniRule annotation (EC:2.3.1.12UniRule annotation)
Gene namesi
ORF Names:APA07_12160Imported
OrganismiAcetobacter pasteurianus IFO 3283-07Imported
Taxonomic identifieri634454 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesAcetobacteraceaeAcetobacter
ProteomesiUP000000949: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. pyruvate dehydrogenase complex Source: InterPro
Complete GO annotation...

Structurei

3D structure databases

ProteinModelPortaliC7JX05.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the 2-oxoacid dehydrogenase family.UniRule annotation
Contains 1 lipoyl-binding domain.UniRule annotation

Keywords - Domaini

LipoylUniRule annotationSAAS annotation

Phylogenomic databases

KOiK00627.

Family and domain databases

Gene3Di3.30.559.10. 1 hit.
4.10.320.10. 1 hit.
InterProiIPR003016. 2-oxoA_DH_lipoyl-BS.
IPR001078. 2-oxoacid_DH_actylTfrase.
IPR000089. Biotin_lipoyl.
IPR023213. CAT-like_dom.
IPR004167. E3-bd.
IPR006257. LAT1.
IPR011053. Single_hybrid_motif.
[Graphical view]
PfamiPF00198. 2-oxoacid_dh. 1 hit.
PF00364. Biotin_lipoyl. 1 hit.
PF02817. E3_binding. 1 hit.
[Graphical view]
SUPFAMiSSF47005. SSF47005. 1 hit.
SSF51230. SSF51230. 1 hit.
TIGRFAMsiTIGR01349. PDHac_trf_mito. 1 hit.
PROSITEiPS50968. BIOTINYL_LIPOYL. 1 hit.
PS00189. LIPOYL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C7JX05-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATEILMPAL SPTMTEGKLA RWLKKEGDTV NSGDVLAEIE TDKATMEVEA
60 70 80 90 100
IEEGILGRIL IQEGAEGVAV NTPIAILVEE GEAVPDNIDT PKNVASAEPA
110 120 130 140 150
PVPQPVASAP VAAQAAPAQR ADKPVGRVVA SPLARRIARQ KNIDLAAIKG
160 170 180 190 200
TGPNGRIVKR DVEAALNKAP SAGQVASALP ASGGSSAVPH TTMRKVIARR
210 220 230 240 250
LSESKATIPH FYVSIDVELD ALLALRAQLN AMSPAEGADA FKLSVNDMLI
260 270 280 290 300
KASAVALKQV PEVNASYTED AMILHEDADI SVAVSLDDGL ITPIVKQADR
310 320 330 340 350
KSLKDISQEA KDLIARARAG KLKPEEFQGG TFSISNMGMY GVKDFAAIVN
360 370 380 390 400
PPQAAILAIA AGKKQAVVKG NELAIATVMT VTLSVDHRVV DGAAAARWLS
410
AFRTAVESPL SLVL
Length:414
Mass (Da):43,264
Last modified:October 13, 2009 - v1
Checksum:i70CEC00BE9637960
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP011135 Genomic DNA. Translation: BAI05462.1.
RefSeqiYP_005486950.1. NC_017121.1.

Genome annotation databases

EnsemblBacteriaiBAI05462; BAI05462; APA07_12160.
GeneIDi12074624.
KEGGiapu:APA07_12160.
PATRICi36859655. VBIAcePas143188_1288.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP011135 Genomic DNA. Translation: BAI05462.1.
RefSeqiYP_005486950.1. NC_017121.1.

3D structure databases

ProteinModelPortaliC7JX05.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAI05462; BAI05462; APA07_12160.
GeneIDi12074624.
KEGGiapu:APA07_12160.
PATRICi36859655. VBIAcePas143188_1288.

Phylogenomic databases

KOiK00627.

Enzyme and pathway databases

BioCyciAPAS634454:GL7B-1218-MONOMER.

Family and domain databases

Gene3Di3.30.559.10. 1 hit.
4.10.320.10. 1 hit.
InterProiIPR003016. 2-oxoA_DH_lipoyl-BS.
IPR001078. 2-oxoacid_DH_actylTfrase.
IPR000089. Biotin_lipoyl.
IPR023213. CAT-like_dom.
IPR004167. E3-bd.
IPR006257. LAT1.
IPR011053. Single_hybrid_motif.
[Graphical view]
PfamiPF00198. 2-oxoacid_dh. 1 hit.
PF00364. Biotin_lipoyl. 1 hit.
PF02817. E3_binding. 1 hit.
[Graphical view]
SUPFAMiSSF47005. SSF47005. 1 hit.
SSF51230. SSF51230. 1 hit.
TIGRFAMsiTIGR01349. PDHac_trf_mito. 1 hit.
PROSITEiPS50968. BIOTINYL_LIPOYL. 1 hit.
PS00189. LIPOYL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: IFO 3283Imported.

Entry informationi

Entry nameiC7JX05_ACEPA
AccessioniPrimary (citable) accession number: C7JX05
Entry historyi
Integrated into UniProtKB/TrEMBL: October 13, 2009
Last sequence update: October 13, 2009
Last modified: February 4, 2015
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.