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C7JVB7

- C7JVB7_ACEPA

UniProt

C7JVB7 - C7JVB7_ACEPA

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Protein
Isocitrate dehydrogenase [NADP]
Gene
APA07_06250
Organism
Acetobacter pasteurianus IFO 3283-07
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei77 – 771Substrate By similarity
Binding sitei82 – 821NADP By similarityUniRule annotation
Binding sitei109 – 1091Substrate By similarity
Binding sitei132 – 1321Substrate By similarityUniRule annotation
Sitei139 – 1391Critical for catalysis By similarityUniRule annotation
Sitei211 – 2111Critical for catalysis By similarityUniRule annotation
Metal bindingi251 – 2511Magnesium or manganese By similarityUniRule annotation
Binding sitei259 – 2591NADP By similarityUniRule annotation
Metal bindingi274 – 2741Magnesium or manganese By similarityUniRule annotation
Binding sitei327 – 3271NADP; via amide nitrogen and carbonyl oxygen By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi75 – 773NADP By similarityUniRule annotation
Nucleotide bindingi309 – 3146NADP By similarityUniRule annotation

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  3. magnesium ion binding Source: InterPro

GO - Biological processi

  1. isocitrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciAPAS634454:GL7B-625-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
ORF Names:APA07_06250Imported
OrganismiAcetobacter pasteurianus IFO 3283-07Imported
Taxonomic identifieri634454 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesAcetobacteraceaeAcetobacter
ProteomesiUP000000949: Chromosome

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni94 – 1007Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

KOiK00031.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C7JVB7-1 [UniParc]FASTAAdd to Basket

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MAKIKVKNPV VEMDGDEMTR IIWHFIRERL ILPYLDIDLK YYDLGIENRD    50
ATDDKVTVEA AEATKRYGVA VKCATITPDE ARVKEFGLKK MWRSPNGTIR 100
NILDGTIFRE PIICSNVPRL VPHWTKPIVI GRHAYGDIYR AAETKIPGPG 150
KVTLNYIPED GGEPITLDVH DFKGPGVALG MHNTRASIEG FARASFSYGR 200
DRKLPVYLST KNTILKAYDG MFKDVFQEVY EKEFKAEFEK LGLTYEHRLI 250
DDMVACALKW PGGYVWACKN YDGDVESDIV AQGFGSLGLM TSVLLSPKGD 300
VVEAEAAHGT VTRHYREHQK GKPTSTNPIA SIFAWTRGLA YRGRFDDTPD 350
VVHFANTLEK VCVDTVEGGQ MTKDLALLVG NGTKWLDTQP FLDVLDEKLK 400
QALAKG 406
Length:406
Mass (Da):45,449
Last modified:October 13, 2009 - v1
Checksum:iA80F02387D8F68BD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP011135 Genomic DNA. Translation: BAI04874.1.
RefSeqiYP_005486362.1. NC_017121.1.

Genome annotation databases

GeneIDi12074031.
KEGGiapu:APA07_06250.
PATRICi36858397. VBIAcePas143188_0664.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP011135 Genomic DNA. Translation: BAI04874.1 .
RefSeqi YP_005486362.1. NC_017121.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 12074031.
KEGGi apu:APA07_06250.
PATRICi 36858397. VBIAcePas143188_0664.

Phylogenomic databases

KOi K00031.

Enzyme and pathway databases

BioCyci APAS634454:GL7B-625-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11822. PTHR11822. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Whole-genome analyses reveal genetic instability of Acetobacter pasteurianus."
    Azuma Y., Hosoyama A., Matsutani M., Furuya N., Horikawa H., Harada T., Hirakawa H., Kuhara S., Matsushita K., Fujita N., Shirai M.
    Submitted (APR-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: IFO 3283Imported.

Entry informationi

Entry nameiC7JVB7_ACEPA
AccessioniPrimary (citable) accession number: C7JVB7
Entry historyi
Integrated into UniProtKB/TrEMBL: October 13, 2009
Last sequence update: October 13, 2009
Last modified: July 9, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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