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C7JVB7 (C7JVB7_ACEPA) Unreviewed, UniProtKB/TrEMBL

Last modified April 3, 2013. Version 26. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Isocitrate dehydrogenase [NADP] PIRNR PIRNR000108
EC=1.1.1.42 PIRNR PIRNR000108
Gene names
ORF Names:APA07_06250 EMBL BAI04874.1
OrganismAcetobacter pasteurianus IFO 3283-07 EMBL BAI04874.1
Taxonomic identifier634454 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhodospirillales › Acetobacteraceae › Acetobacter ›

Protein attributes

Sequence length406 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH. PIRNR PIRNR000108

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity. PIRNR PIRNR000108 PIRSR PIRSR000108-3

Sequence similarities

Belongs to the isocitrate and isopropylmalate dehydrogenases family. PIRNR PIRNR000108 RuleBase RU004443

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding75 – 773NADP By similarity PIRSR PIRSR000108-4
Nucleotide binding309 – 3146NADP By similarity PIRSR PIRSR000108-4
Region94 – 1007Substrate binding By similarity PIRSR PIRSR000108-2

Sites

Metal binding2511Magnesium or manganese By similarity PIRSR PIRSR000108-3
Metal binding2741Magnesium or manganese By similarity PIRSR PIRSR000108-3
Binding site771Substrate By similarity PIRSR PIRSR000108-2
Binding site821NADP By similarity PIRSR PIRSR000108-4
Binding site1091Substrate By similarity PIRSR PIRSR000108-2
Binding site1321Substrate By similarity PIRSR PIRSR000108-2
Binding site2591NADP By similarity PIRSR PIRSR000108-4
Binding site3271NADP; via amide nitrogen and carbonyl oxygen By similarity PIRSR PIRSR000108-4
Site1391Critical for catalysis By similarity PIRSR PIRSR000108-1
Site2111Critical for catalysis By similarity PIRSR PIRSR000108-1

Sequences

Sequence LengthMass (Da)Tools
C7JVB7 [UniParc].

Last modified October 13, 2009. Version 1.
Checksum: A80F02387D8F68BD

FASTA40645,449
        10         20         30         40         50         60 
MAKIKVKNPV VEMDGDEMTR IIWHFIRERL ILPYLDIDLK YYDLGIENRD ATDDKVTVEA 

        70         80         90        100        110        120 
AEATKRYGVA VKCATITPDE ARVKEFGLKK MWRSPNGTIR NILDGTIFRE PIICSNVPRL 

       130        140        150        160        170        180 
VPHWTKPIVI GRHAYGDIYR AAETKIPGPG KVTLNYIPED GGEPITLDVH DFKGPGVALG 

       190        200        210        220        230        240 
MHNTRASIEG FARASFSYGR DRKLPVYLST KNTILKAYDG MFKDVFQEVY EKEFKAEFEK 

       250        260        270        280        290        300 
LGLTYEHRLI DDMVACALKW PGGYVWACKN YDGDVESDIV AQGFGSLGLM TSVLLSPKGD 

       310        320        330        340        350        360 
VVEAEAAHGT VTRHYREHQK GKPTSTNPIA SIFAWTRGLA YRGRFDDTPD VVHFANTLEK 

       370        380        390        400 
VCVDTVEGGQ MTKDLALLVG NGTKWLDTQP FLDVLDEKLK QALAKG

« Hide

References

[1]"Whole-genome analyses reveal genetic instability of Acetobacter pasteurianus."
Azuma Y., Hosoyama A., Matsutani M., Furuya N., Horikawa H., Harada T., Hirakawa H., Kuhara S., Matsushita K., Fujita N., Shirai M.
Submitted (APR-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: IFO 3283 EMBL BAI04874.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP011135 Genomic DNA. Translation: BAI04874.1.
RefSeqYP_005486362.1. NC_017121.1.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAI04874; BAI04874; APA07_06250.
GeneID12074031.
KEGGapu:APA07_06250.
PATRIC36858397. VBIAcePas143188_0664.

Phylogenomic databases

KOK00031.

Family and domain databases

Gene3D3.40.718.10. 1 hit.
InterProIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERPTHR11822. PTHR11822. 1 hit.
PfamPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsTIGR00127. nadp_idh_euk. 1 hit.
PROSITEPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameC7JVB7_ACEPA
AccessionPrimary (citable) accession number: C7JVB7
Entry history
Integrated into UniProtKB/TrEMBL: October 13, 2009
Last sequence update: October 13, 2009
Last modified: April 3, 2013
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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