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Protein

Isocitrate dehydrogenase [NADP]

Gene

APA03_06250

Organism
Acetobacter pasteurianus IFO 3283-03
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Binds 1 Mg(2+) or Mn2+ ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei77 – 771SubstrateUniRule annotation
Binding sitei82 – 821NADPUniRule annotation
Binding sitei109 – 1091SubstrateUniRule annotation
Binding sitei132 – 1321SubstrateUniRule annotation
Sitei139 – 1391Critical for catalysisUniRule annotation
Sitei211 – 2111Critical for catalysisUniRule annotation
Metal bindingi251 – 2511Magnesium or manganeseUniRule annotation
Binding sitei259 – 2591NADPUniRule annotation
Metal bindingi274 – 2741Magnesium or manganeseUniRule annotation
Binding sitei327 – 3271NADP; via amide nitrogen and carbonyl oxygenUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi75 – 773NADPUniRule annotation
Nucleotide bindingi309 – 3146NADPUniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. isocitrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciAPAS634453:GL7D-625-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
ORF Names:APA03_06250Imported
OrganismiAcetobacter pasteurianus IFO 3283-03Imported
Taxonomic identifieri634453 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesAcetobacteraceaeAcetobacter
ProteomesiUP000001620: Chromosome

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni94 – 1007Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

KOiK00031.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C7JL49-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAKIKVKNPV VEMDGDEMTR IIWHFIRERL ILPYLDIDLK YYDLGIENRD
60 70 80 90 100
ATDDKVTVEA AEATKRYGVA VKCATITPDE ARVKEFGLKK MWRSPNGTIR
110 120 130 140 150
NILDGTIFRE PIICSNVPRL VPHWTKPIVI GRHAYGDIYR AAETKIPGPG
160 170 180 190 200
KVTLNYIPED GGEPITLDVH DFKGPGVALG MHNTRASIEG FARASFSYGR
210 220 230 240 250
DRKLPVYLST KNTILKAYDG MFKDVFQEVY EKEFKAEFEK LGLTYEHRLI
260 270 280 290 300
DDMVACALKW PGGYVWACKN YDGDVESDIV AQGFGSLGLM TSVLLSPKGD
310 320 330 340 350
VVEAEAAHGT VTRHYREHQK GKPTSTNPIA SIFAWTRGLA YRGRFDDTPD
360 370 380 390 400
VVHFANTLEK VCVDTVEGGQ MTKDLALLVG NGTKWLDTQP FLDVLDEKLK

QALAKG
Length:406
Mass (Da):45,449
Last modified:October 13, 2009 - v1
Checksum:iA80F02387D8F68BD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP011128 Genomic DNA. Translation: BAI01826.1.
RefSeqiYP_005477221.1. NC_017100.1.

Genome annotation databases

EnsemblBacteriaiBAI01826; BAI01826; APA03_06250.
GeneIDi12064394.
KEGGiapf:APA03_06250.
PATRICi36851891. VBIAcePas145093_0663.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP011128 Genomic DNA. Translation: BAI01826.1.
RefSeqiYP_005477221.1. NC_017100.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAI01826; BAI01826; APA03_06250.
GeneIDi12064394.
KEGGiapf:APA03_06250.
PATRICi36851891. VBIAcePas145093_0663.

Phylogenomic databases

KOiK00031.

Enzyme and pathway databases

BioCyciAPAS634453:GL7D-625-MONOMER.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: IFO 3283Imported.

Entry informationi

Entry nameiC7JL49_ACEPA
AccessioniPrimary (citable) accession number: C7JL49
Entry historyi
Integrated into UniProtKB/TrEMBL: October 13, 2009
Last sequence update: October 13, 2009
Last modified: February 4, 2015
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.