C7JHY1 (C7JHY1_ACEP3) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Thiopurine S-methyltransferase HAMAP MF_00812
EC=2.1.1.67 HAMAP MF_00812

Alternative name(s):
Thiopurine methyltransferase HAMAP MF_00812

Gene names

Name:	tpm HAMAP MF_00812
Ordered Locus Names:	APA01_14450

Organism

Acetobacter pasteurianus (strain NBRC 3283 / LMG 1513 / CCTM 1153) [Complete proteome] [HAMAP]

Taxonomic identifier

634452 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhodospirillales › Acetobacteraceae › Acetobacter

Protein attributes

Sequence length	213 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	S-adenosyl-L-methionine + a thiopurine = S-adenosyl-L-homocysteine + a thiopurine S-methylether. HAMAP MF_00812 SAAS SAAS008854
Subcellular location	Cytoplasm By similarity HAMAP MF_00812.
Sequence similarities	Belongs to the methyltransferase superfamily. TPMT family. HAMAP MF_00812

Ontologies

Keywords
Cellular component	Cytoplasm HAMAP MF_00812 SAAS SAAS008854
Ligand	S-adenosyl-L-methionine HAMAP MF_00812 SAAS SAAS022474
Molecular function	Methyltransferase HAMAP MF_00812 SAAS SAAS022474 EMBL BAH99585.1 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	thiopurine S-methyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Binding site	10	1	S-adenosyl-L-methionine By similarity HAMAP MF_00812
	Binding site	45	1	S-adenosyl-L-methionine; via carbonyl oxygen By similarity HAMAP MF_00812
	Binding site	66	1	S-adenosyl-L-methionine By similarity HAMAP MF_00812
	Binding site	124	1	S-adenosyl-L-methionine By similarity HAMAP MF_00812

Sequences

	Sequence		Length	Mass (Da)
	C7JHY1 [UniParc]. Last modified October 13, 2009. Version 1. Checksum: 052F433B5076A684	FASTA	213	23,607
	10 20 30 40 50 60 MDAQFWNMKW QKNQIGFHLA AVNPLLVKYF PVMGLKEGAR VFVPLCGKTL DIHWFLQRGM 70 80 90 100 110 120 NVVGVELSQI AVEQLFSEIG LTPQISNMAP NMQCFKAKNL NIFVGDIFTL SRALLGDVQA 130 140 150 160 170 180 IYDRAALVAL PPAMRAAYAE HLMDISGKAE QLLVTLEYDQ SCIAGPPFSV TRQDIHRYYG 190 200 210 AEYTINCLES TAVTGGLKGG VPATENVWVL KPE

References

[1]

"Whole-genome analyses reveal genetic instability of Acetobacter pasteurianus." Azuma Y., Hosoyama A., Matsutani M., Furuya N., Horikawa H., Harada T., Hirakawa H., Kuhara S., Matsushita K., Fujita N., Shirai M. Nucleic Acids Res. 37:5768-5783(2009) [PubMed: 19638423] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP011121 Genomic DNA. Translation: BAH99585.1.
RefSeq	YP_003187965.1. NC_013209.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	C7JHY1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	8435489.
GenomeReviews	Gene locus APA01_14450 in contig AP011121_GR.
KEGG	apt:APA01_14450.
PATRIC	20633292. VBIAcePas139226_1514.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	QGDIFTL.
Family and domain databases
HAMAP	MF_00812. Thiopur_methtran. [Tree]
InterPro	IPR022474. Thiopur_S-MeTfrase_Se/Te_detox. IPR008854. Thiopurine_S-MeTrfase. IPR016822. Thiopurine_S-MeTrfase_sub. [Graphical view]
KO	K00569.
PANTHER	PTHR10259. PTHR10259. 1 hit.
Pfam	PF05724. TPMT. 1 hit. [Graphical view]
PIRSF	PIRSF023956. Thiopurine_S-methyltransferase. 1 hit.
TIGRFAMs	TIGR03840. TMPT_Se_Te. 1 hit.
ProtoNet	Search...

Entry information

Entry name

C7JHY1_ACEP3

Accession

Primary (citable) accession number: C7JHY1

Entry history

Integrated into UniProtKB/TrEMBL:	October 13, 2009
Last sequence update:	October 13, 2009
Last modified:	December 14, 2011
This is version 17 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)