C7JCV1 (C7JCV1_ACEP3) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase HAMAP MF_00061
Short name=CMK HAMAP MF_00061
EC=2.7.1.148 HAMAP MF_00061

Alternative name(s):
4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase HAMAP MF_00061

Gene names

Name:	ispE HAMAP MF_00061
Ordered Locus Names:	APA01_04030

Organism

Acetobacter pasteurianus (strain NBRC 3283 / LMG 1513 / CCTM 1153) [Complete proteome] [HAMAP]

Taxonomic identifier

634452 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhodospirillales › Acetobacteraceae › Acetobacter

Protein attributes

Sequence length	301 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol By similarity. HAMAP MF_00061
Catalytic activity	ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol = ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol. HAMAP MF_00061
Pathway	Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 3/6. HAMAP MF_00061
Sequence similarities	Belongs to the GHMP kinase family. IspE subfamily. HAMAP MF_00061

Ontologies

Keywords
Biological process	Isoprene biosynthesis HAMAP MF_00061
Ligand	ATP-binding HAMAP MF_00061 RuleBase RU003563 Nucleotide-binding
Molecular function	Kinase HAMAP MF_00061 RuleBase RU003563 EMBL BAH98554.1 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	terpenoid biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity Inferred from electronic annotation. Source: HAMAP ATP binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Nucleotide binding	112 – 122	11	ATP By similarity HAMAP MF_00061
Sites
	Active site	20	1	By similarity HAMAP MF_00061
	Active site	154	1	By similarity HAMAP MF_00061

Sequences

	Sequence		Length	Mass (Da)
	C7JCV1 [UniParc]. Last modified October 13, 2009. Version 1. Checksum: D61075EB45132143	FASTA	301	31,462
	10 20 30 40 50 60 MTVDVLDVAT TTLTEIAPAK INLYLHVTGR RPDGYHLLDS LVVFAGAGDV LHYEPGTEPL 70 80 90 100 110 120 HLKLEGRFGR ALGADAAGAD NLVMKAAAVL RDLAGPQANV QGGCLVLEKN LPVASGIGGG 130 140 150 160 170 180 SADAAAALRL LNRAWNAQVD EPTLFRVAET LGADVPVCLL SQTVRMEGIG ETLTPAPRLP 190 200 210 220 230 240 ECGLVLVNCG QAVSTPDVFR KRTGDFVPRA DLPQSWPNSA AMVATLKAQE NSLETPACTV 250 260 270 280 290 300 CPPVKKVLAD IAAQPDCQLA RMSGSGATCF GVFPTVEAAR EAADRLAEAH AAWWVWGGAL V

References

[1]

"Whole-genome analyses reveal genetic instability of Acetobacter pasteurianus." Azuma Y., Hosoyama A., Matsutani M., Furuya N., Horikawa H., Harada T., Hirakawa H., Kuhara S., Matsushita K., Fujita N., Shirai M. Nucleic Acids Res. 37:5768-5783(2009) [PubMed: 19638423] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP011121 Genomic DNA. Translation: BAH98554.1.
RefSeq	YP_003186934.1. NC_013209.1.
3D structure databases
ProteinModelPortal	C7JCV1.
ModBase	Search...
Protein-protein interaction databases
STRING	C7JCV1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	8434635.
GenomeReviews	Gene locus APA01_04030 in contig AP011121_GR.
KEGG	apt:APA01_04030.
PATRIC	20631070. VBIAcePas139226_0416.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	CQLARMS.
Family and domain databases
HAMAP	MF_00061. IspE. [Tree]
InterPro	IPR006204. GHMP_kinase. IPR013750. GHMP_kinase_C. IPR004424. IspE. IPR020568. Ribosomal_S5_D2-typ_fold. IPR014721. Ribosomal_S5_D2-typ_fold_subgr. [Graphical view]
Gene3D	G3DSA:3.30.230.10. Ribosomal_S5_D2-type_fold. 1 hit.
KO	K00919.
PANTHER	PTHR20861:SF2. IspE. 1 hit.
Pfam	PF08544. GHMP_kinases_C. 1 hit. PF00288. GHMP_kinases_N. 1 hit. [Graphical view]
PIRSF	PIRSF010376. IspE. 1 hit.
SUPFAM	SSF54211. Ribosomal_S5_D2-typ_fold. 1 hit.
TIGRFAMs	TIGR00154. IspE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

C7JCV1_ACEP3

Accession

Primary (citable) accession number: C7JCV1

Entry history

Integrated into UniProtKB/TrEMBL:	October 13, 2009
Last sequence update:	October 13, 2009
Last modified:	December 14, 2011
This is version 20 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)