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Protein

Putative glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

C1Q_01026

Organism
Saccharomyces cerevisiae (strain JAY291) (Baker's yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in amino sugar synthesis (formation of chitin, supplies the amino sugars of asparagine-linked oligosaccharides of glycoproteins).By similarity

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.

Pathwayi: UDP-N-acetyl-alpha-D-glucosamine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes alpha-D-glucosamine 6-phosphate from D-fructose 6-phosphate.
Proteins known to be involved in this subpathway in this organism are:
  1. Putative glutamine--fructose-6-phosphate aminotransferase [isomerizing] (C1Q_01026)
This subpathway is part of the pathway UDP-N-acetyl-alpha-D-glucosamine biosynthesis, which is itself part of Nucleotide-sugar biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes alpha-D-glucosamine 6-phosphate from D-fructose 6-phosphate, the pathway UDP-N-acetyl-alpha-D-glucosamine biosynthesis and in Nucleotide-sugar biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei2Nucleophile; for GATase activityPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferase, Transferase

Enzyme and pathway databases

UniPathwayiUPA00113; UER00528

Names & Taxonomyi

Protein namesi
Recommended name:
Putative glutamine--fructose-6-phosphate aminotransferase [isomerizing] (EC:2.6.1.16)
Short name:
GFAT
Alternative name(s):
D-fructose-6-phosphate amidotransferase
Hexosephosphate aminotransferase
Gene namesi
ORF Names:C1Q_01026
OrganismiSaccharomyces cerevisiae (strain JAY291) (Baker's yeast)
Taxonomic identifieri574961 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000008073 Componenti: Unassembled WGS sequence

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003934111 – 720Putative glutamine--fructose-6-phosphate aminotransferase [isomerizing]Add BLAST720

Proteomic databases

PRIDEiC7GL41

Structurei

3D structure databases

ProteinModelPortaliC7GL41
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 321Glutamine amidotransferase type-2PROSITE-ProRule annotationAdd BLAST320
Domaini393 – 532SIS 1PROSITE-ProRule annotationAdd BLAST140
Domaini565 – 710SIS 2PROSITE-ProRule annotationAdd BLAST146

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

OrthoDBiEOG092C0ST1

Family and domain databases

CDDicd05008 SIS_GlmS_GlmD_1, 1 hit
cd05009 SIS_GlmS_GlmD_2, 1 hit
InterProiView protein in InterPro
IPR017932 GATase_2_dom
IPR035466 GlmS/AgaS_SIS
IPR035490 GlmS/FrlB_SIS
IPR005855 GlmS_trans
IPR029055 Ntn_hydrolases_N
IPR001347 SIS
PANTHERiPTHR10937:SF0 PTHR10937:SF0, 1 hit
PfamiView protein in Pfam
PF01380 SIS, 2 hits
SUPFAMiSSF56235 SSF56235, 2 hits
PROSITEiView protein in PROSITE
PS51278 GATASE_TYPE_2, 1 hit
PS51464 SIS, 2 hits

Sequencei

Sequence statusi: Complete.

C7GL41-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCGIFGYCNF LIEKTRGEII DTLIEGLQAL EYKEYDSSGI SIQGDELKSL
60 70 80 90 100
NIYKQTGKIS SLKEEIDLYN LNKNLPFISH CGIAHTRRAT HGGLRRANCH
110 120 130 140 150
PHNSDPSNEF VVVHNGVITN FANLKALLVA KGYVFKSDTD TECIPKLYKH
160 170 180 190 200
IYDTSIELGY NLDFHVLTNL VLKELEGSYG LLCTSSHFPD EVVAARKGSP
210 220 230 240 250
LVIGVKGKTD MDVNFVEVEY LDQEEDYLKL NTQTKSSGNV LAAAPVKYNT
260 270 280 290 300
CLRKSPPLRS QYLRNSTTST FNHGSSTETP AENGLPRPME FYLSSDCASL
310 320 330 340 350
ARYVSKVVYL EDNDTAHIYD GELHIHCSKI GSEDFSFRTV QKLELELSKI
360 370 380 390 400
KKGPYDNFMQ KEIYEQCETT KNVMRGRVDA FTNRVVLGGL ENWLTELRRA
410 420 430 440 450
KRIIMIASKS SFHSCLAARP IFEELMEVPV NVELALDFVD RNCCIFRNDV
460 470 480 490 500
CIFVSRSGET TDTINALNYC IKKEAVTIGV VNCSGSSISR FTHCGVHTNT
510 520 530 540 550
GPEKGIATTK SYTSQYIALV MIALWMSEDL VSKIERRKEI IQALTIVPSQ
560 570 580 590 600
IKEVLELEPL IIELCDKKLK QHDTFLLLGR GYQFASALEG ASKMKEISYV
610 620 630 640 650
HSESILTDEL GHRVLAVTSD NPPIIAFATK DAFSPKIASC IDQIIERKGN
660 670 680 690 700
PIIICNKGHK IWEQDKQKGN VVTLEVPQTV DCLQGILNVI PLQLISYWLA
710 720
IKKDIGVDLP RDSAMSAPDI
Length:720
Mass (Da):80,561
Last modified:April 20, 2010 - v2
Checksum:iFCDCAB9E434094A6
GO

Sequence cautioni

The sequence EEU08477 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ACFL01000033 Genomic DNA Translation: EEU08477.1 Different initiation.

Similar proteinsi

Entry informationi

Entry nameiYM084_YEAS2
AccessioniPrimary (citable) accession number: C7GL41
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 20, 2010
Last sequence update: April 20, 2010
Last modified: May 23, 2018
This is version 37 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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