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C7FH46 (C7FH46_9INFA) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 15. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesSubmitted name:
Neuraminidase EMBL ACT36688.1
Gene names
Name:NA EMBL ACT36688.1
OrganismInfluenza A virus (A/California/07/2009(H1N1)) EMBL ACT36688.1
Taxonomic identifier641809 [NCBI]
Taxonomic lineageViruses › ssRNA negative-strand viruses › Orthomyxoviridae › Influenzavirus A ›

Protein attributes

Sequence length469 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates. SAAS SAAS011040

Subunit structure

Homotetramer By similarity. SAAS SAAS011040

Sequences

Sequence LengthMass (Da)Tools
C7FH46 [UniParc].

Last modified September 22, 2009. Version 1.
Checksum: 7B712B363CB0E178

FASTA46951,613
        10         20         30         40         50         60 
MNPNQKIITI GSVCMTIGMA NLILQIGNII SIWISHSIQL GNQNQIETCN QSVITYENNT 

        70         80         90        100        110        120 
WVNQTYVNIS NTNFAAGQSV VSVKLAGNSS LCPVSGWAIY SKDNSVRIGS KGDVFVIREP 

       130        140        150        160        170        180 
FISCSPLECR TFFLTQGALL NDKHSNGTIK DRSPYRTLMS CPIGEVPSPY NSRFESVAWS 

       190        200        210        220        230        240 
ASACHDGINW LTIGISGPDN GAVAVLKYNG IITDTIKSWR NNILRTQESE CACVNGSCFT 

       250        260        270        280        290        300 
VMTDGPSNGQ ASYKIFRIEK GKIVKSVEMN APNYHYEECS CYPDSSEITC VCRDNWHGSN 

       310        320        330        340        350        360 
RPWVSFNQNL EYQIGYICSG IFGDNPRPND KTGSCGPVSS NGANGVKGFS YKYGNGVWIG 

       370        380        390        400        410        420 
RTKSISSRNG FEMIWDPNGW TGTDNNFSIK QDIVGINEWS GYSGSFVQHP ELTGLDCIRP 

       430        440        450        460 
CFWVELIRGR PKENTIWTSG SSISFCGVNS DTVGWSWPDG AELPFTIDK

« Hide

References

[1]"Human infection with novel swine H1N1 influenza."
Shu B., Balish A., Garten R., Smith C., Emery S., Barnes J., Deyde V., Klimov A., Cox N.
Submitted (JUL-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: A/California/07/2009 EMBL ACT36688.1.
[2]"H1N1 2009 pandemic influenza virus: resistance of the I223R neuraminidase mutant explained by kinetic and structural analysis."
van der Vries E., Collins P.J., Vachieri S.G., Xiong X., Liu J., Walker P.A., Haire L.F., Hay A.J., Schutten M., Osterhaus A.D., Martin S.R., Boucher C.A., Skehel J.J., Gamblin S.J.
PLoS Pathog. 8:e1002914-e1002914(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) OF 83-469.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		GQ377078 Viral cRNA. Translation: ACT36688.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
4B7QX-ray2.73A/B/C/D1-469[»]
4B7RX-ray1.90A/B/C/D83-469[»]
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D2.120.10.10. 1 hit.
InterProIPR001860. Glyco_hydro_34.
IPR011040. Sialidases.
[Graphical view]
PfamPF00064. Neur. 1 hit.
[Graphical view]
SUPFAMSSF50939. Sialidase. 1 hit.
ProtoNetSearch...

Entry information

Entry nameC7FH46_9INFA
AccessionPrimary (citable) accession number: C7FH46
Entry history
Integrated into UniProtKB/TrEMBL: September 22, 2009
Last sequence update: September 22, 2009
Last modified: May 1, 2013
This is version 15 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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