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C7FH46

- C7FH46_9INFA

UniProt

C7FH46 - C7FH46_9INFA

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Protein

Neuraminidase

Gene

NA

Organism
Influenza A virus (A/California/07/2009(H1N1))
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.SAAS annotation

Cofactori

Binds 1 calcium ion per subunit.SAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi294 – 2941Calcium 1; via carbonyl oxygenImported
Metal bindingi298 – 2981Calcium 1; via carbonyl oxygenImported
Metal bindingi324 – 3241Calcium 1Imported
Metal bindingi342 – 3421Calcium 1; via carbonyl oxygenImported
Metal bindingi344 – 3441Calcium 1; via carbonyl oxygenImported
Metal bindingi376 – 3761Calcium 2Imported
Metal bindingi378 – 3781Calcium 2Imported
Metal bindingi384 – 3841Calcium 2Imported
Metal bindingi386 – 3861Calcium 2; via carbonyl oxygenImported

GO - Molecular functioni

  1. exo-alpha-sialidase activity Source: InterPro
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

GlycosidaseSAAS annotation, Hydrolase

Keywords - Ligandi

CalciumSAAS annotationImported, Metal-bindingSAAS annotationImported

Names & Taxonomyi

Protein namesi
Recommended name:
NeuraminidaseSAAS annotation (EC:3.2.1.18SAAS annotation)
Gene namesi
Name:NAImported
OrganismiInfluenza A virus (A/California/07/2009(H1N1))Imported
Taxonomic identifieri641809 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesOrthomyxoviridaeInfluenzavirus A

Subcellular locationi

Virion membrane SAAS annotation. Host apical cell membrane SAAS annotation; Single-pass type II membrane protein SAAS annotation

GO - Cellular componenti

  1. host cell plasma membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
  3. virion membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Host cell membraneSAAS annotation, Host membrane, Membrane, VirionSAAS annotation

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi88 – 881N-linked (GlcNAc...)Imported
Glycosylationi146 – 1461N-linked (GlcNAc...)Imported
Glycosylationi235 – 2351N-linked (GlcNAc...)Imported

Keywords - PTMi

Disulfide bondSAAS annotation

Interactioni

Subunit structurei

Homotetramer.SAAS annotation

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4B7QX-ray2.73A/B/C/D1-469[»]
4B7RX-ray1.90A/B/C/D83-469[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotation

Family and domain databases

Gene3Di2.120.10.10. 1 hit.
InterProiIPR001860. Glyco_hydro_34.
IPR011040. Sialidases.
[Graphical view]
PfamiPF00064. Neur. 1 hit.
[Graphical view]
SUPFAMiSSF50939. SSF50939. 1 hit.

Sequencei

Sequence statusi: Complete.

C7FH46-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNPNQKIITI GSVCMTIGMA NLILQIGNII SIWISHSIQL GNQNQIETCN
60 70 80 90 100
QSVITYENNT WVNQTYVNIS NTNFAAGQSV VSVKLAGNSS LCPVSGWAIY
110 120 130 140 150
SKDNSVRIGS KGDVFVIREP FISCSPLECR TFFLTQGALL NDKHSNGTIK
160 170 180 190 200
DRSPYRTLMS CPIGEVPSPY NSRFESVAWS ASACHDGINW LTIGISGPDN
210 220 230 240 250
GAVAVLKYNG IITDTIKSWR NNILRTQESE CACVNGSCFT VMTDGPSNGQ
260 270 280 290 300
ASYKIFRIEK GKIVKSVEMN APNYHYEECS CYPDSSEITC VCRDNWHGSN
310 320 330 340 350
RPWVSFNQNL EYQIGYICSG IFGDNPRPND KTGSCGPVSS NGANGVKGFS
360 370 380 390 400
YKYGNGVWIG RTKSISSRNG FEMIWDPNGW TGTDNNFSIK QDIVGINEWS
410 420 430 440 450
GYSGSFVQHP ELTGLDCIRP CFWVELIRGR PKENTIWTSG SSISFCGVNS
460
DTVGWSWPDG AELPFTIDK
Length:469
Mass (Da):51,613
Last modified:September 22, 2009 - v1
Checksum:i7B712B363CB0E178
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GQ377078 Viral cRNA. Translation: ACT36688.1.
KC781784 Viral cRNA. Translation: AGI54791.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GQ377078 Viral cRNA. Translation: ACT36688.1 .
KC781784 Viral cRNA. Translation: AGI54791.1 .

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4B7Q X-ray 2.73 A/B/C/D 1-469 [» ]
4B7R X-ray 1.90 A/B/C/D 83-469 [» ]
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 2.120.10.10. 1 hit.
InterProi IPR001860. Glyco_hydro_34.
IPR011040. Sialidases.
[Graphical view ]
Pfami PF00064. Neur. 1 hit.
[Graphical view ]
SUPFAMi SSF50939. SSF50939. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Human infection with novel swine H1N1 influenza."
    Shu B., Balish A., Garten R., Smith C., Emery S., Barnes J., Deyde V., Klimov A., Cox N.
    Submitted (JUL-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: A/California/07/2009Imported.
  2. "H1N1 2009 pandemic influenza virus: resistance of the I223R neuraminidase mutant explained by kinetic and structural analysis."
    van der Vries E., Collins P.J., Vachieri S.G., Xiong X., Liu J., Walker P.A., Haire L.F., Hay A.J., Schutten M., Osterhaus A.D., Martin S.R., Boucher C.A., Skehel J.J., Gamblin S.J.
    PLoS Pathog. 8:e1002914-e1002914(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) OF 83-469 IN COMPLEX WITH CALCIUM, GLYCOSYLATION AT ASN-88; ASN-146 AND ASN-235.
  3. "Influenza Sequencing Activity group."
    Klimov A., Barnes J., Shaw M., Cox N., Garten R., Xu X.
    Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: A/California/07/2009Imported.

Entry informationi

Entry nameiC7FH46_9INFA
AccessioniPrimary (citable) accession number: C7FH46
Entry historyi
Integrated into UniProtKB/TrEMBL: September 22, 2009
Last sequence update: September 22, 2009
Last modified: October 29, 2014
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3