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C7FH46

- C7FH46_9INFA

UniProt

C7FH46 - C7FH46_9INFA

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Protein
Submitted name: Neuraminidase
Gene
NA
Organism
Influenza A virus (A/California/07/2009(H1N1))
Status
Unreviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.SAAS annotations

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi294 – 2941Calcium 1; via carbonyl oxygenImported
Metal bindingi298 – 2981Calcium 1; via carbonyl oxygenImported
Metal bindingi324 – 3241Calcium 1Imported
Metal bindingi342 – 3421Calcium 1; via carbonyl oxygenImported
Metal bindingi344 – 3441Calcium 1; via carbonyl oxygenImported
Metal bindingi376 – 3761Calcium 2Imported
Metal bindingi378 – 3781Calcium 2Imported
Metal bindingi384 – 3841Calcium 2Imported
Metal bindingi386 – 3861Calcium 2; via carbonyl oxygenImported

GO - Molecular functioni

  1. exo-alpha-sialidase activity Source: InterPro
  2. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

GlycosidaseSAAS annotations, Hydrolase

Keywords - Ligandi

CalciumImported, Metal-bindingImported

Names & Taxonomyi

Protein namesi
Submitted name:
NeuraminidaseImported
Gene namesi
Name:NAImported
OrganismiInfluenza A virus (A/California/07/2009(H1N1))Imported
Taxonomic identifieri641809 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesOrthomyxoviridaeInfluenzavirus A

Subcellular locationi

GO - Cellular componenti

  1. host cell plasma membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
  3. virion membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Host cell membraneSAAS annotations, Host membrane, Membrane, VirionSAAS annotations

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi88 – 881N-linked (GlcNAc...)Imported
Glycosylationi146 – 1461N-linked (GlcNAc...)Imported
Glycosylationi235 – 2351N-linked (GlcNAc...)Imported

Keywords - PTMi

Disulfide bondSAAS annotations

Interactioni

Subunit structurei

Homotetramer By similarity.SAAS annotations

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4B7QX-ray2.73A/B/C/D1-469[»]
4B7RX-ray1.90A/B/C/D83-469[»]

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotations

Family and domain databases

Gene3Di2.120.10.10. 1 hit.
InterProiIPR001860. Glyco_hydro_34.
IPR011040. Sialidases.
[Graphical view]
PfamiPF00064. Neur. 1 hit.
[Graphical view]
SUPFAMiSSF50939. SSF50939. 1 hit.

Sequencei

Sequence statusi: Complete.

C7FH46-1 [UniParc]FASTAAdd to Basket

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MNPNQKIITI GSVCMTIGMA NLILQIGNII SIWISHSIQL GNQNQIETCN    50
QSVITYENNT WVNQTYVNIS NTNFAAGQSV VSVKLAGNSS LCPVSGWAIY 100
SKDNSVRIGS KGDVFVIREP FISCSPLECR TFFLTQGALL NDKHSNGTIK 150
DRSPYRTLMS CPIGEVPSPY NSRFESVAWS ASACHDGINW LTIGISGPDN 200
GAVAVLKYNG IITDTIKSWR NNILRTQESE CACVNGSCFT VMTDGPSNGQ 250
ASYKIFRIEK GKIVKSVEMN APNYHYEECS CYPDSSEITC VCRDNWHGSN 300
RPWVSFNQNL EYQIGYICSG IFGDNPRPND KTGSCGPVSS NGANGVKGFS 350
YKYGNGVWIG RTKSISSRNG FEMIWDPNGW TGTDNNFSIK QDIVGINEWS 400
GYSGSFVQHP ELTGLDCIRP CFWVELIRGR PKENTIWTSG SSISFCGVNS 450
DTVGWSWPDG AELPFTIDK 469
Length:469
Mass (Da):51,613
Last modified:September 22, 2009 - v1
Checksum:i7B712B363CB0E178
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GQ377078 Viral cRNA. Translation: ACT36688.1.
KC781784 Viral cRNA. Translation: AGI54791.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GQ377078 Viral cRNA. Translation: ACT36688.1 .
KC781784 Viral cRNA. Translation: AGI54791.1 .

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4B7Q X-ray 2.73 A/B/C/D 1-469 [» ]
4B7R X-ray 1.90 A/B/C/D 83-469 [» ]
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 2.120.10.10. 1 hit.
InterProi IPR001860. Glyco_hydro_34.
IPR011040. Sialidases.
[Graphical view ]
Pfami PF00064. Neur. 1 hit.
[Graphical view ]
SUPFAMi SSF50939. SSF50939. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Human infection with novel swine H1N1 influenza."
    Shu B., Balish A., Garten R., Smith C., Emery S., Barnes J., Deyde V., Klimov A., Cox N.
    Submitted (JUL-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: A/California/07/2009Imported.
  2. "H1N1 2009 pandemic influenza virus: resistance of the I223R neuraminidase mutant explained by kinetic and structural analysis."
    van der Vries E., Collins P.J., Vachieri S.G., Xiong X., Liu J., Walker P.A., Haire L.F., Hay A.J., Schutten M., Osterhaus A.D., Martin S.R., Boucher C.A., Skehel J.J., Gamblin S.J.
    PLoS Pathog. 8:e1002914-e1002914(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) OF 83-469 IN COMPLEX WITH CALCIUM, GLYCOSYLATION AT ASN-88; ASN-146 AND ASN-235.
  3. "Influenza Sequencing Activity group."
    Klimov A., Barnes J., Shaw M., Cox N., Garten R., Xu X.
    Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: A/California/07/2009Imported.

Entry informationi

Entry nameiC7FH46_9INFA
AccessioniPrimary (citable) accession number: C7FH46
Entry historyi
Integrated into UniProtKB/TrEMBL: September 22, 2009
Last sequence update: September 22, 2009
Last modified: June 11, 2014
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3

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