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C7FFR5

- C7FFR5_HUMAN

UniProt

C7FFR5 - C7FFR5_HUMAN

Protein
Submitted name:

Estrogen receptor alpha 3*,4,5,6,7*/765 isoform

Gene

ESR1

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    GO - Molecular functioni

    1. chromatin binding Source: Ensembl
    2. ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity Source: Ensembl
    3. sequence-specific DNA binding Source: InterPro
    4. zinc ion binding Source: InterPro

    GO - Biological processi

    1. androgen metabolic process Source: Ensembl
    2. antral ovarian follicle growth Source: Ensembl
    3. cellular response to estrogen stimulus Source: Ensembl
    4. epithelial cell development Source: Ensembl
    5. epithelial cell proliferation involved in mammary gland duct elongation Source: Ensembl
    6. male gonad development Source: Ensembl
    7. mammary gland alveolus development Source: Ensembl
    8. mammary gland branching involved in pregnancy Source: Ensembl
    9. positive regulation of fibroblast proliferation Source: Ensembl
    10. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    11. prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis Source: Ensembl
    12. prostate epithelial cord elongation Source: Ensembl
    13. regulation of apoptotic process Source: Ensembl
    14. regulation of branching involved in prostate gland morphogenesis Source: Ensembl
    15. uterus development Source: Ensembl
    16. vagina development Source: Ensembl

    Keywords - Molecular functioni

    ReceptorImported

    Keywords - Biological processi

    Transcription, Transcription regulationSAAS annotation

    Keywords - Ligandi

    DNA-bindingSAAS annotation, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Estrogen receptor alpha 3*,4,5,6,7*/765 isoformImported
    Gene namesi
    Name:ESR1Imported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. nucleus Source: UniProtKB-KW

    Keywords - Cellular componenti

    NucleusSAAS annotation

    Expressioni

    Gene expression databases

    ArrayExpressiC7FFR5.
    BgeeiC7FFR5.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the nuclear hormone receptor family.UniRule annotation
    Contains nuclear receptor DNA-binding domain.SAAS annotation

    Keywords - Domaini

    Zinc-fingerSAAS annotation

    Family and domain databases

    Gene3Di3.30.50.10. 1 hit.
    InterProiIPR001628. Znf_hrmn_rcpt.
    IPR013088. Znf_NHR/GATA.
    [Graphical view]
    PfamiPF00105. zf-C4. 1 hit.
    [Graphical view]
    SMARTiSM00399. ZnF_C4. 1 hit.
    [Graphical view]
    PROSITEiPS51030. NUCLEAR_REC_DBD_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    C7FFR5-1 [UniParc]FASTAAdd to Basket

    « Hide

    GYHYGVWSCE GCKAFFKRSI QGHNDYMCPA TNQCTIDKNR RKSCQA       46
    Length:46
    Mass (Da):5,304
    Last modified:September 22, 2009 - v1
    Checksum:i076A9107F1505735
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    GQ366704 mRNA. Translation: ACU29456.1.
    UniGeneiHs.208124.
    Hs.744830.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    GQ366704 mRNA. Translation: ACU29456.1 .
    UniGenei Hs.208124.
    Hs.744830.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Miscellaneous databases

    ChiTaRSi ESR1. human.
    NextBioi 35483635.

    Gene expression databases

    ArrayExpressi C7FFR5.
    Bgeei C7FFR5.

    Family and domain databases

    Gene3Di 3.30.50.10. 1 hit.
    InterProi IPR001628. Znf_hrmn_rcpt.
    IPR013088. Znf_NHR/GATA.
    [Graphical view ]
    Pfami PF00105. zf-C4. 1 hit.
    [Graphical view ]
    SMARTi SM00399. ZnF_C4. 1 hit.
    [Graphical view ]
    PROSITEi PS51030. NUCLEAR_REC_DBD_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Decreased alternative splicing of estrogen receptor-alpha mRNA in the Alzheimer's disease brain."
      Ishunina T.A., Swaab D.F.
      Neurobiol. Aging 33:286-296(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: White matter of brainImported.

    Entry informationi

    Entry nameiC7FFR5_HUMAN
    AccessioniPrimary (citable) accession number: C7FFR5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 22, 2009
    Last sequence update: September 22, 2009
    Last modified: October 1, 2014
    This is version 42 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.