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Protein
Submitted name:

Estrogen receptor alpha 3*,4,5,6,7*/765 isoform

Gene

ESR1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. chromatin binding Source: Ensembl
  2. ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity Source: Ensembl
  3. sequence-specific DNA binding Source: InterPro
  4. zinc ion binding Source: InterPro

GO - Biological processi

  1. androgen metabolic process Source: Ensembl
  2. antral ovarian follicle growth Source: Ensembl
  3. cellular response to estrogen stimulus Source: Ensembl
  4. epithelial cell development Source: Ensembl
  5. epithelial cell proliferation involved in mammary gland duct elongation Source: Ensembl
  6. male gonad development Source: Ensembl
  7. mammary gland alveolus development Source: Ensembl
  8. mammary gland branching involved in pregnancy Source: Ensembl
  9. positive regulation of fibroblast proliferation Source: Ensembl
  10. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  11. prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis Source: Ensembl
  12. prostate epithelial cord elongation Source: Ensembl
  13. regulation of apoptotic process Source: Ensembl
  14. regulation of branching involved in prostate gland morphogenesis Source: Ensembl
  15. uterus development Source: Ensembl
  16. vagina development Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

ReceptorImported

Keywords - Biological processi

Transcription, Transcription regulationSAAS annotation

Keywords - Ligandi

DNA-bindingSAAS annotation, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
Estrogen receptor alpha 3*,4,5,6,7*/765 isoformImported
Gene namesi
Name:ESR1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

NucleusSAAS annotation

Expressioni

Gene expression databases

BgeeiC7FFR5.
ExpressionAtlasiC7FFR5. baseline and differential.

Family & Domainsi

Sequence similaritiesi

Belongs to the nuclear hormone receptor family.UniRule annotation
Contains nuclear receptor DNA-binding domain.SAAS annotation

Keywords - Domaini

Zinc-fingerSAAS annotation

Family and domain databases

Gene3Di3.30.50.10. 1 hit.
InterProiIPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00105. zf-C4. 1 hit.
[Graphical view]
SMARTiSM00399. ZnF_C4. 1 hit.
[Graphical view]
PROSITEiPS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

C7FFR5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40 
GYHYGVWSCE GCKAFFKRSI QGHNDYMCPA TNQCTIDKNR RKSCQA
Length:46
Mass (Da):5,304
Last modified:September 22, 2009 - v1
Checksum:i076A9107F1505735
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GQ366704 mRNA. Translation: ACU29456.1.
UniGeneiHs.208124.
Hs.744830.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GQ366704 mRNA. Translation: ACU29456.1.
UniGeneiHs.208124.
Hs.744830.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

ChiTaRSiESR1. human.
NextBioi35483635.

Gene expression databases

BgeeiC7FFR5.
ExpressionAtlasiC7FFR5. baseline and differential.

Family and domain databases

Gene3Di3.30.50.10. 1 hit.
InterProiIPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00105. zf-C4. 1 hit.
[Graphical view]
SMARTiSM00399. ZnF_C4. 1 hit.
[Graphical view]
PROSITEiPS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Decreased alternative splicing of estrogen receptor-alpha mRNA in the Alzheimer's disease brain."
    Ishunina T.A., Swaab D.F.
    Neurobiol. Aging 33:286-296(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: White matter of brainImported.

Entry informationi

Entry nameiC7FFR5_HUMAN
AccessioniPrimary (citable) accession number: C7FFR5
Entry historyi
Integrated into UniProtKB/TrEMBL: September 22, 2009
Last sequence update: September 22, 2009
Last modified: October 29, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.