ID   C7DTX2_HUMAN            Unreviewed;       495 AA.
AC   C7DTX2;
DT   22-SEP-2009, integrated into UniProtKB/TrEMBL.
DT   22-SEP-2009, sequence version 1.
DT   27-MAR-2024, entry version 59.
DE   RecName: Full=Steroid 21-hydroxylase {ECO:0000256|ARBA:ARBA00044116};
DE            EC=1.14.14.16 {ECO:0000256|ARBA:ARBA00044040};
DE   AltName: Full=21-OHase {ECO:0000256|ARBA:ARBA00044304};
DE   AltName: Full=Cytochrome P-450c21 {ECO:0000256|ARBA:ARBA00044217};
DE   AltName: Full=Cytochrome P450 21 {ECO:0000256|ARBA:ARBA00044342};
DE   AltName: Full=Cytochrome P450 XXI {ECO:0000256|ARBA:ARBA00044282};
DE   AltName: Full=Cytochrome P450-C21 {ECO:0000256|ARBA:ARBA00044265};
GN   Name=CYP21A2 {ECO:0000313|EMBL:ACT35424.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:ACT35424.1};
RN   [1] {ECO:0000313|EMBL:ACT35424.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=19505723; DOI=10.1016/j.molimm.2009.04.033;
RA   Blasko B., Banlaki Z., Gyapay G., Pozsonyi E., Sasvari-Szekely M.,
RA   Rajczy K., Fust G., Szilagyi A.;
RT   "Linkage analysis of the C4A/C4B copy number variation and polymorphisms of
RT   the adjacent steroid 21-hydroxylase gene in a healthy population.";
RL   Mol. Immunol. 46:2623-2629(2009).
RN   [2] {ECO:0000313|EMBL:ACT35424.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Blasko B., Banlaki Z., Gyapay G., Pozsonyi E., Sasvari-Szekely M.,
RA   Rajczy K., Fust G., Szilagyi A.;
RL   Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=heme b; Xref=ChEBI:CHEBI:60344;
CC         Evidence={ECO:0000256|ARBA:ARBA00001970};
CC   -!- SIMILARITY: Belongs to the cytochrome P450 family.
CC       {ECO:0000256|ARBA:ARBA00010617, ECO:0000256|RuleBase:RU000461}.
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DR   EMBL; GQ222298; ACT35424.1; -; Genomic_DNA.
DR   PeptideAtlas; C7DTX2; -.
DR   ChiTaRS; CYP21A2; human.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-KW.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR   GO; GO:0006629; P:lipid metabolic process; IEA:UniProtKB-KW.
DR   CDD; cd20674; CYP21; 1.
DR   Gene3D; 1.10.630.10; Cytochrome P450; 1.
DR   InterPro; IPR001128; Cyt_P450.
DR   InterPro; IPR017972; Cyt_P450_CS.
DR   InterPro; IPR002401; Cyt_P450_E_grp-I.
DR   InterPro; IPR036396; Cyt_P450_sf.
DR   PANTHER; PTHR24289; STEROID 17-ALPHA-HYDROXYLASE/17,20 LYASE; 1.
DR   PANTHER; PTHR24289:SF14; STEROID 21-HYDROXYLASE-LIKE; 1.
DR   Pfam; PF00067; p450; 1.
DR   PRINTS; PR00463; EP450I.
DR   PRINTS; PR00385; P450.
DR   SUPFAM; SSF48264; Cytochrome P450; 1.
DR   PROSITE; PS00086; CYTOCHROME_P450; 1.
PE   3: Inferred from homology;
KW   Heme {ECO:0000256|ARBA:ARBA00022617, ECO:0000256|RuleBase:RU000461};
KW   Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|RuleBase:RU000461};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW   Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|RuleBase:RU000461};
KW   Monooxygenase {ECO:0000256|RuleBase:RU000461};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU000461};
KW   Steroid-binding {ECO:0000256|ARBA:ARBA00022665}.
SQ   SEQUENCE   495 AA;  55919 MW;  1EEB3C3A8051B7DA CRC64;
     MLLLGLLLLL PLLAGARLLW NWWKLRSLHL PPLAPGFLHL LQPDLPIYLL GLTQKFGPIY
     RLHLGLQDVV VLNSKRTIEE AMVKKWADFA GRPEPLTYKL VSXNYPDLSL GDYSLLWKAH
     KKLTRSALLL GIRDSMEPVV EQLTQEFCER MRAQPGTPVA IEEEFSLLTC SIICYLTFGD
     KIKDDNLMPA YYKCIQEVLK TWSHWSIQIV DVIPFLRFFP NPGLRRLKQA IXKRDHIVEM
     QLRQHKESLV AGQWRDMMDY MLQGVAQPTM EEGSGQLLEG HVHMAAVDLL IGGTETTANT
     LSWAVVFLLH HPEIQQRLQE XLXHELGPGA SSSRVPYKXR ARXPLLNAXX XXXXXXXXXX
     XXXXXXXXXX XXSISGYXIP EGTVIIPNLQ GAHLDETVWE RPHEFWPDRF LEPGKNSRAL
     AFGCGARVCL GEPLARLELF VVLTRLLQAF TLLPSGDALP SLQPLPHCSV ILKMQPFQVR
     LQPRGMGAHS PGQSQ
//